1,721,017 research outputs found
Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease
Full text linkRecent evidence has revealed the importance of reciprocal functional interactions between different types of mononuclear cells in coordinating the repair of injured muscles. In particular, signals released from the inflammatory infiltrate and from mesenchymal interstitial cells (also known as fibro-adipogenic progenitors (FAPs)) appear to instruct muscle stem cells (satellite cells) to break quiescence, proliferate and differentiate. Interestingly, conditions that compromise the functional integrity of this network can bias muscle repair toward pathological outcomes that are typically observed in chronic muscular disorders, that is, fibrotic and fatty muscle degeneration as well as myofiber atrophy. In this review, we will summarize the current knowledge on the regulation of this network in physiological and pathological conditions, and anticipate the potential contribution of its cellular components to relatively unexplored conditions, such as aging and physical exercise
p300 is required for MyoD dependent cell cycle arrest and muscle specific gene transcription
No full text
Differentiation-activated p38 pathway recruits the SWI/SNF chromatin-remodelling complex to muscle promoters
No full text
Molecular mechanisms regulating DNA damage-activated differentiation checkpoint in muscle cells: a “chromatin interface” between cellular differentiation and senescence.
No full textMyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions
No full textDuring skeletal myogenesis, muscle-regulatory factors bHLH and MEF2 promote the expression of muscle-specific genes by recruiting several chromatin-modifying complexes on specific DNA regulatory sequences. A number of MyoD-interacting proteins have been reported, but whether they are recruited to the chromatin of myogenic loci, and the relationship with other chromatin bound proteins is unknown. We show that MyoD recruits cdk9/cyclin T2, together with the histone acetyltransferases p300 and PCAF, and the chromatin remodeling complex SWI/SNF, on promoters and enhancers of muscle-specific genes, and that this event correlates with the acetylation of histone tails, remodeling of chromatin, and phosphorylation of the C-terminal domain (CTD) of the RNA polymerase II at these elements
Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX
No full textHepatitis B virus pX activates NF-kB-dependent transcription through a Raf-independent pathway
No full text- …
