1,721,103 research outputs found

    BLAARCHITETTURA Nuovi Architetti Italiani.

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    LUIGI PRESTINENZA PUGLISI PROSEGUE LA RICERCA SUGLI ARCHITETTI ITALIANI EMERGENTI e CI PRESENTA BLAARCHITETTURA, DI ALBERTO LESSAN E JACOPO BRACCO, CHE CON GUSTO, MISURA E INTELLIGENZA, RIESCONO A LAVORARE ANCHE SU PICCOLI PROGETTI DILATANDO GLI SPAZI E TRASFORMANDO AMBIENTI SENZA PARTICOLARI QUALITA' IN ORGANISMI STIMOLANTI IN CUI VIVERE

    Direct effects of estrogen on the vessel wall

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    The understanding of the biological effects of estrogen on the vessel wall has improved dramatically since the discovery of estrogen receptors (ERs). Most, but not all estrogen-mediated effects in blood vessels are thought to be mediated by ERs. Two major ER subclasses have been characterized so far: the ER alpha and the more recently described ER beta. This review will primarily focus on a new perspective that highlights ERs as essential mediators of the vascular effects of estrogen. In view of the rising research interest in this area, it can be also expected that tissue- and ER subclass-selective agonists and antagonists will be developed over the next few years, thus providing invaluable tools for pharmacological and clinical applications
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