3,105 research outputs found
Nab-paclitaxel in pretreated metastatic breast cancer: evaluation of activity, safety, and quality of life
No full textObjective: Metastatic breast cancer (MBC) is an incurable disease; the treatment of this
disease prolongs survival, improving the quality of life (QoL) with a balance between efficacy
and toxicity of the treatment. In recent years, treatment with nab-paclitaxel has improved the
already known antitumor activity of conventional paclitaxel, in terms of increased efficacy
and better tolerability. The aim of this study was to evaluate nab-paclitaxel in Italian patients
with MBC.
Methods: We conducted a retrospective analysis of 90 patients with histologically confirmed diagnosis of MBC. To evaluate the efficacy of nab-paclitaxel, overall survival (OS),
progression-free survival (PFS), and overall response rate were the primary endpoints,
whereas carbohydrate antigen 15.3 (Ca15.3) reduction, QoL, and tolerability were secondary endpoints.
Results: The median OS was 10.4 months, the median PFS was 6.8 months. A considerable
difference Ca15.3 before and after treatment was observed. Descriptive and regression analyses
were done to examine the associations between Ca15.3 response and OS, demonstrating good
correlation, revealing that Ca15.3 reduction is an important predictor of OS.
Conclusion: Nab-paclitaxel is an effective and well-tolerated treatment of patients affected by
MBC. The drug showed an improved tolerability profile. With all the limitations of the observational nature of our results, nab-paclitaxel has proven to be an effective and safe therapeutic
option in patients with MBC
Lo scambio e il legame
No full textLo studio analizza il modello economico dello scambio economico e finanziario, nel mondo contemporaneo, visto come modello relazionale che esige la libertà e l'interruzione dei legami affettivi come importante requisito per progredire nell'aderenza al modello liberista. Si mostra anche come il paradigma del dono, (dare, ricevere e ricambiare) rappresenta un momento resistenziale nella realtà odierna per mantenere il legame, interpersonale e sociale
Le groupe transculturel au la des appartenances
No full textLe but de cet article est de décrire le projet et l'expérience du séminaire groupe de group-analyse trans-culturel menées à Marsala en 2008, en essayant de résumer certains éléments du processus et quelques réflexions
Lavoro, organizzazione e cura
No full textIl volume raccoglie contributi sul significato del lavoro nei contesti organizzativi e nei contesti di cura
Il gruppo di transito evolutivo come risorsa innovativa nel counselling psicologico
No full textNel lavoro di counselling svolto con studenti universitari appare indicato l'uso dei dispositivi mediani o allargati. La funzione che svolgono è infatti quella di aiutare lo studente ad elaborare la cultura specifica del proprio gruppo familiare e del proprio ambiente di provenienza e di confrontare tale rappresentazione con quella proposta dagli altri membri del gruppo. Si evidenziano, in tal modo le differenze che possono essere problematizzate
The life of relationship in globalized financial economic devices. Evidences from the experience of a group-analytic transcultural workshop.
No full textSummary
The present contribution - starting from the experience of the EATGA Workshop 2011 that took place in Palermo, whose theme was “Intersubjective bonds in a globalized economy”- invites reflection on the quality of the life of relationships and intersubjective connectedness in the social contemporary world.
One of the characterizing cultural phenomena influencing contemporary reality is made up of the dominant and pervasive presence of the logic and language of the financial markets in policies and activities that organize and articulate daily life.
The theoretical hypothesis driving our research is that the structures of subjectivity, the meaning and the way of being in a relationship are characteristics (cultural themes) that emerge within a historically defined cultural system/device.
In such a theoretical perspective, the cultural themes (i.e. gift, market,) are incorporated or interiorized by men belonging to a shared cultural system and so become elements of the shared subjectivity and of the meanings given to intersubjective exchanges and bonds.
From the workshop experience some meanings emerge concerning the role of the economical-financial system in promoting codes and symbols that define the shape and the sense of relationships.
The cultural codes of the market have come out of the economic circle in which they have originated and are offered as organizers of affections and of relationships.
This denotes and marks the current critical historical moment, in which the values and the cultural codes organized on trust, on reciprocity, on community participation and solidarity seem to be interdicted
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