4,310 research outputs found
Validity and reliability of a Taiwan Chinese version of Community Screening Instrument for Dementia
No full textWorld Alzheimer report 2015: the global impact of dementia
No full textToday, over 46 million people live with dementia worldwide, more than the population of Spain. This number is estimated to increase to 131.5 million by 2050.
Dementia also has a huge economic impact. Today, the total estimated worldwide cost of dementia is US 742 billion), Google (US 357 billion).
In many parts of the world, there is a growing awareness of dementia, but across the globe it remains the case that a diagnosis of dementia can bring with it stigma and social isolation. Today, we estimate that 94% of people living with dementia in low and middle income countries are cared for at home. These are regions where health and care systems often provide limited or no support to people living with dementia or to their families.
The 2015 World Alzheimer Report updates data on the prevalence, incidence, cost and trends of dementia worldwide. It also estimates how these numbers will increase in the future, leaving us with no doubt that dementia, including Alzheimer’s disease and other causes, is one of the biggest global public health and social care challenges facing people today and in the future.
Authors
Prof Martin Prince The Global Observatory for Ageing and Dementia Care, King’s College London, UK
Prof Anders Wimo Department of Neurobiology, Care sciences and Society, Karolinska Institute, Stockholm, Sweden
Dr Maëlenn Guerchet The Global Observatory for Ageing and Dementia Care, King’s College London, UK
Miss Gemma-Claire Ali The Global Observatory for Ageing and Dementia Care, King’s College London, UK
Dr Yu-Tzu Wu Cambridge Institute of Public Health, University of Cambridge, UK
Dr Matthew Prina The Global Observatory for Ageing and Dementia Care, King’s College London, UK Alzheimer\u27s Disease Internationa
Aquatic insect populations in transplanted and natural populations of the purple pitcher plant, Sarracenia purpurea, on Prince Edward Island, Canada
No full textIn early July 1991, 234 pitcher plants (Sarracenia pulpurea) were transplanted from a Prince Edward Island bog being mined for peat into three bogs that varied with respect to previous pitcher plant abundance. One bog had a thriving natural pitcher plant population prior to transplant, while the other two had fewer than three pitcher plants. Between mid-June and late August 1993, abundances of the pitcher plant inquilines Wyeomyia smithii (Diptera: Culicidae), Metriocnemus knabi (Diptera: Chironomidae) and an unidentified sarcophagid fly (Diptera: Sarcophagidae) from transplant bogs were compared with remaining populations in die source bog and with other natural populations. Of the three inquilines, W. smithii was the most severely affected by transplant; it was extremely rare or absent in transplanted pitchers, although it was found in all other bogs investigated on Prince Edward Island. Metriocnemus knabi larvae were common in ail bogs investigated, except for those transplant bogs where pitcher plants were rare prior to transplant. Sarcophagid larvae were found in all of the bogs sampled, and were apparently unaffected by transplant. Desiccation during the transplant process, as well as the time of the transplant, may play a role in the success of recolonization of the pitcher plants after transplanting.PT: J; CR: ADDICOTT JF, 1974, ECOLOGY, V55, P475 BRADSHAW WE, 1984, AM MIDL NAT, V112, P294 CAMERON CJ, 1977, CAN J ZOOL, V55, P2018 ELLIOTT JM, 1977, FRESHWATER BIOL ASS, V25 FAIRCHILD WL, 1987, CAN ENTOMOL, V119, P647 FARKAS MJ, 1986, CAN ENTOMOL, V118, P1307 FARKAS MJ, 1986, CAN J ZOOL, V64, P285 FISH D, 1978, AM MIDL NAT, V99, P172 FORSYTH AB, 1975, CAN J ZOOL, V53, P174 GIVNISH TJ, 1989, PLANT ANIMAL INTERAC, P243 HEARD SB, 1994, ECOLOGY, V75, P1647 HEARD SB, 1994, ENVIRON ENTOMOL, V23, P1250 ISTOCK CA, 1975, EVOLUTION, V29, P296 ISTOCK CA, 1983, PHYTOTELMATA TERREST, P191 JUNIPER BE, 1989, CARNIVOROUS PLANTS MOGI M, 1980, TROPICAL MED, V22, P1 MOORE PD, 1974, PEATLANDS NASTASE AJ, 1991, AM MIDL NAT, V125, P356 NASTASE AJ, 1995, AM MIDL NAT, V133, P44 PATERSON CG, 1982, CAN J ZOOL, V60, P3075 SCHNELL DE, 1976, CARNIVOROUS PLANTS U WALLIS RC, 1967, MOSQ NEWS, V27, P9; NR: 22; TC: 5; J9: CAN J ZOOL; PG: 8; GA: VQ081Source type: Electronic(1
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Use of spatiotemporal analysis of laboratory submission data to identify potential outbreaks of new or emerging diseases in cattle in Great Britain.
No full textBACKGROUND: New and emerging diseases of livestock may impact animal welfare, trade and public health. Early detection of outbreaks can reduce the impact of these diseases by triggering control measures that limit the number of cases that occur. The aim of this study was to investigate whether prospective spatiotemporal methods could be used to identify outbreaks of new and emerging diseases in scanning surveillance data. SaTScan was used to identify clusters of unusually high levels of submissions where a diagnosis could not be reached (DNR) using different probability models and baselines. The clusters detected were subjected to a further selection process to reduce the number of false positives and a more detailed epidemiological analysis to ascertain whether they were likely to represent real outbreaks.
RESULTS: 187,925 submissions of clinical material from cattle were made to the Regional Laboratory of the Veterinary Laboratories Agency (VLA) between 2002 and 2007, and the results were stored on the VLA FarmFile database. 16,925 of these were classified as DNRs and included in the analyses. Variation in the number and proportion of DNRs was found between syndromes and regions, so a spatiotemporal analysis for each DNR syndrome was done. Six clusters were identified using the Bernoulli model after applying selection criteria (e.g. size of cluster). The further epidemiological analysis revealed that one of the systemic clusters could plausibly have been due to Johne's disease. The remainder were either due to misclassification or not consistent with a single diagnosis.
CONCLUSIONS: Our analyses have demonstrated that spatiotemporal methods can be used to detect clusters of new or emerging diseases, identify clusters of known diseases that may not have been diagnosed and identify misclassification in the data, and highlighted the impact of data quality on the ability to detect outbreaks. Spatiotemporal methods should be used alongside current temporal methods for analysis of scanning surveillance data. These statistical analyses should be followed by further investigation of possible outbreaks to determine whether cases have common features suggesting that these are likely to represent real outbreaks, or whether issues with the collection or processing of information have resulted in false positives
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Pure-rotational 1D-CARS spatiotemporal thermometry with a single regenerative amplifier system
No full textWe report spatiotemporal pure-rotational coherent anti-Stokes Raman spectroscopy (CARS) in a one-dimensional imaging arrangement obtained with a single ultrafast regenerative amplifier system. The femtosecond pump/Stokes photon pairs, used for impulsive excitation, are delivered by an external compressor operating on a ∼35% beam split of the uncompressed amplifier output (2.5 mJ/pulse). The picosecond 1.2 mJ probe pulse is produced via the second-harmonic bandwidth compression (SHBC) of the ∼65% remainder of the amplifier output (4.5 mJ/pulse), which originates from the internal compressor. The two pump/Stokes and probe pulses are spatially, temporally, and repetition-wise correlated at the measurement, and the signal generation plane is relayed by a wide-field coherent imaging spectrometer onto the detector plane, which is refreshed at the same repetition rate as the ultrafast regenerative amplifier system. We demonstrate 1 kHz cinematographic 1D-CARS gas-phase thermometry across an unstable premixed methane/air flame-front, achieved with a single-shot precision <1% and accuracy <3%, 1.4 mm field of view, and an excellent <20 µm line-spread function.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
Cross cultural comparison of depressive symptoms in Europe does not support sterotypes of aging
No full text- …
