1,721,464 research outputs found
Quo vadis, affinity? Clinical evidences and computer-assisted simulations in the Imatinib saga
No full textMolecular simulation for naniomedicine and targeted therapy
No full textThe chapter describes the role of multiscale molecular simulation to the design and development of nanovectors for gene therpy and drugs for targeted therapy
The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic
Full text link: COST Action CA17140 Cancer Nanomedicine-from the bench to the bedside (Nano2Clinic,) is the first, pan-European interdisciplinary network of representatives from academic institutions and small and medium enterprises including clinical research organizations (CROs) devoted to the development of nanosystems carrying anticancer drugs from their initial design, preclinical testing of efficacy, pharmacokinetics and toxicity to the preparation of detailed protocols needed for the first phase of their clinical studies. By promoting scientific exchanges, technological implementation, and innovative solutions, the action aims at providing a timely instrument to rationalize and focus research efforts at the European level in dealing with the grand challenge of nanomedicine translation in cancer, one of the major and societal-burdening human pathologies. Within CA17140, dendrimers in all their forms (from covalent to self-assembling dendrons) play a vital role as powerful nanotheranostic agents in oncology; therefore, the purpose of this review work is to gather and summarize the major results in the field stemming from collaborative efforts in the framework of the European Nano2Clinic COST Action
Atomistic molecular dynamics simulations of gas diffusion and solubility in rubbery amorphous hydrocarbon polymers
No full text
Xanthan gum in drug delivery
No full textThis chapter explores the versatile uses of xanthan gum (XG) in the formulation of drug delivery systems (DDSs). XG, a natural polysaccharide derived from Xanthomonas campestris, has received significant attention from the pharmaceutical industry because of its unique rheological properties, biocompatibility, and mucoadhesive nature. The contribution provides an overview of this biopolymer, its structure, properties, and various formulations used in drug delivery. It discusses the role of XG in the development of sustained-release formulations, targeted DDSs, mucoadhesive drug carriers, and nanoparticulate systems. In addition, the chapter highlights recent advances, challenges, and future perspectives in utilizing XG to improve drug delivery efficiency and therapeutic outcomes. © 2025 Elsevier Ltd. All rights reserved
- …
