1,721,033 research outputs found
Combination therapies for improved management of lower urinary tract symptoms/benign prostatic hyperplasia
No full textSeveral urological and nonurological conditions can contribute to the onset of lower urinary tract symptoms (LUTS), including benign prostatic hyperplasia (BPH), which is one of the main underlying causes in male patients. Six pharmacological classes (α-adrenoceptor blockers [ABs], 5α-reductase inhibitors [5ARIs], phytotherapeutics, antimuscarinics [AMs], β3-adrenoceptor agonists and phosphodiesterase type 5 inhibitors [PDE5Is]) are available, alone or in combination, for the treatment of male LUTS. The aim of this review is to summarize the latest evidence on combination medical treatments for male patients with LUTS/BPH. Standard combinations include AB + 5ARI (for patients with increased prostate volume who are at risk for BPH progression); AB + PDE5I (for patients with concomitant erectile dysfunction); and AB + AM or β3 agonist (for patients with persistent storage symptoms and not at risk for acute urinary retention). Other possible multidrug treatments have been proposed in preliminary studies, but further randomized controlled trials are needed to determine whether these putative strategies will eventually be considered a new standard for patients with LUTS/BPH. The possibility of tailoring BPH treatment according to different patient characteristics and expectations, using two or more drugs, seems a promising path in the field of LUTS/BPH management; however, physicians should consider the risk of increasing costs without proven long-term efficacy with most of these combination treatments
Influenza dei disallineamenti sulla trasmissione di ruote dentate cilindriche a denti dritti
No full textProposal for Tip Relief Modification to reduce Noise in Spur Gears and sensitivity to meshing conditions
No full textIn the paper a new Tip Relief Profile Modification for spur Gears is presented. The topography here proposed is a classical linear profile modification with a parabolic fillet (Linear- Parabolic modification).
The parabolic fillet extension is treated as a parameter and its effect investigated.
The proposed topography is able to take advantages from both Linear, and Parabolic tip relief. The evolution from Linear to Parabolic is discussed in terms of Peak to Peak Transmission Error. Anomalous contact conditions due to particular tip relief modification are reported, and maps are obtained in order to find optimum tip relief by taking into account contact conditions boundaries too
- …
