1,721,015 research outputs found

    Subacute necrotizing encephalomyelopathy (Leigh's disease): clinical correlation with computerized tomography in the diagnosis of the juvenile and adult form

    No full text
    Abstract A computerized tomography (CT) scan was performed on 6 surviving patients with a suspected diagnosis of subacute necrotizing encephalomyelopathy of the juvenile and adult forms. Bilateral low density areas were observed in the putamina in all cases. This CT pattern conformed with the characteristic pathological changes of the disease. Once the possibility of Wilson's disease or an earlier episode of acute cerebral hypoxia, syndromes which both display a similar appearance in CT, is excluded, a diagnosis of subacute necrotizing encephalomyelopathy may be considered in cases showing bilateral low density areas in the basal ganglia, especially in the putamina, and with a consistent clinical history

    brainstem auditary evoked responses in multiple sclerosis patients

    No full text
    98 patients suffering from Multiple classified according to McDonald and Halliday's criteria were tested by means of brainstem auditory evoked responses (BAERs). Percentages of BAER abnormalities correlated satisfactorily with the extent of clinical involvement, the highest percentage (58,1 %) ocóurring in definite M.S. patients. Evoked response changes were also found in patients without clinical brainstem involvement. Our data suggest a way to monitor the course of the disease and to assess the effects of various treatment protocols

    Crural amyotrophy associated with a parietal lesion: a case report

    No full text
    Abstract The authors have observed a 33-year-old woman with a 3-year history of a clinical syndrome characterised by atrophy of the musculature of the left foot and leg with impaired motor function, associated with a paracentral cortical oligodendroglioma located in the right parietal region. Clinical, neuroradiological (MRI), electrophysiological (electromyography: EMG; motor evoked potential: MEP; median and tibial somatosensory evoked potential: m-SEP and t-SEP), and neuropsychological studies were performed every year for three years. Neurological examination showed an abnormal gait along with foot drop, pes cavus and pyramidal involvement. MEP and t-SEP recordings were abnormal on the left side, while EMG and neuropsychological tests gave normal results, which were unmodified over time. Our observations suggest that the crural amyotrophy observed in this case may be defined as of "parietal" or "central" origin, a clinical feature which more frequently affects the hand. A review of the literature is presented
    corecore