1,721,083 research outputs found
Decreased contractile responses to isoproterenol in isolated cardiac myocytes from ageing guinea-pigs
No full textWe have characterized the age-related changes of contractility and β-adrenoceptor function in isolated cardiac myocytes from guinea-pigs. We used either adult animals from 2 to 14 weeks of age, where body weight increases linearly with age, or senescent ones aged between 53-65 weeks. There was some indication of a decrease in contractility in maximum Ca2+ with age, with significant differences between a young (≤4 weeks, weight 600 g) group in contraction amplitude expressed as percentage shortening (but not when expressed as μm change in length) or contraction and relaxation velocities. This decline was continued into senescence, and ANOVA showed a significant difference between the three groups for contraction amplitude (percentage shortening, 12.2 ± 0.9%, young, n = 31; 9.5 ± 0.6%, n = 28 aged; 6.7 ± 0.8%, n = 6, senescent; P = 0.005), and contraction or relaxation velocities (P52 weeks). © 1995
Comparison of ventricular long-axis function in patients with cardiac amyloidosis versus idiopathic restrictive cardiomyopathy.
No full textPrognostic relevance of atrial fibrillation in patients with chronic heart failure on long-term treatment with beta-blockers: results from COMET
No full textRole of heart rate, systolic blood pressure and beta-blocker dose in the COMET study: prognostic value but lack of interaction with the effects of carvedilol compared to metoprolol.
No full textPrognostic relevance of atrial fibrillation in patients with chronic heart failure on long-term treatment with beta-blockers: results from COMET.
No full textClinical profile and outcome of anaemic patients with chronic heart failure in the COMET trial
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