196,017 research outputs found
Tenosinovite delle caviglie come segno d'esordio di sarcoidosi in un paziente con rettocolite ulcerosa.
No full textValue of C reactive protein in the assessment of erosive osteoarthritis of the hand
No full textObjective: To investigate the value of serum C reactive protein (CRP) as a marker of erosive osteoarthritis (EOA) of the hand.
Methods: Ninety eight patients, 67 with EOA and 31 with non-EOA of the hand, were included in the study and analysed for radiographic score (RS), number of erosions, and joint count (JC) at clinical observation and at bone scintigraphy. CRP was assayed in a serum sample by a highly sensitive immunonephelometric method.
Results: The median (interquartile range) CRP level was 4.7 (2.4 - 6.9) mg/l in the EOA and 2.1 (0.5 - 4.9) mg/l in the non-EOA group ( p = 0.001). In all patients, CRP correlated with RS (r(s) = 0.43, p< 0.001), and mainly with JC at clinical observation ( r(s) = 0.72, p< 0.001) and at bone scintigraphy ( r(s) = 0.47, p< 0.001). The correlation of CRP with RS and JC was confirmed at clinical observation and at bone scintigraphy in the EOA subgroup, but only with JC at clinical observation in the non-EOA subgroup.
Conclusions: CRP levels are higher in EOA than in non-EOA patients. These levels probably reflect the disease activity of EOA, as suggested by correlations between CRP and JC at clinical observation and at bone scintigraphy
Frequenza dei cristalli di pirofosfato di calcio diidrato nell'artrosi: studio retrospettivo su 852 pazienti
No full textIl liquido sinoviale nell'artrite sarcoidea. Differenze nelle caratteristiche infiammatorie e livelli di interleuchine tra le forme acute e croniche
No full textArticular manifestations in inflammatory bowel disease patients: a prospective study
No full textBackground and aims: Rheumatic manifestations are frequent in inflammatory bowel disease (IBD) and are associated with a wide range of clinical patterns.
Methods: Articular symptoms and signs were investigated by questionnaire in a cohort of 651 pts, mean age 42 +/- 14 years, followed at two referral hospitals over a 12-month period.
Results: 142 ulcerative colitis (UC) and 120 Crohn's disease (CD) patients referred articular pain during their IBD history: in 46% this was associated with active IBD, in 56% symptoms were intermittent and in 19% symptoms preceded IBD diagnosis. 62 pts (28 UC, 34 CID) complaining of articular symptoms at the time of the interview, were investigated by the rheumatologist: arthropathy was axial in 52%, oligoarticular in 16% and polyarticular in 23%. Oligoarthritis commonly involved the lower limbs and was more commonly associated with UC. The mean number of small joints involved was significantly higher in CD than in UC pts (9.9 +/- 8.2 vs. 5.6 +/- 4.3; p < 0.01). Bone scintigraphy was abnormal in 70% of pts.
Conclusions: Prevalence of self-reported articular symptoms in IBD patients exceeds 40% with 9.5% incidence during 1-year follow up. Symptoms predict entheropatic involvement of the locomotor system. (c) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved
Mud-bath treatment in spondylitis associated with inflammatory bowel disease - a pilot randomised clinical trial.
No full text
Evaluation of spinal mobility by pocket goniometer (Inclimed) in patients with ankylosing spondylitis: preliminary data.
No full textBackground: Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting sacroiliac joints and whole the spine. The clinical instrument of functional evaluation of spine in AS is mainly based on BASMI score.
Objectives: The aim of our study was to verify the usefulness of new gravity-dependent and compass-needle pocket goniometer (IncliMed R, University of Padua) for AS spinal mobility measurement.
Methods: Forty one consecutive out-patients with AS (New York modified criteria) entered the study; 33 males and 8 females, age 46.5±12.3 years (range 21-73). Their active range of motion (AROM) of whole spine were evaluated by the same metrologist (B.L.) throughout the IncliMed R. The results of angular measures in 3 plane (frontal, coronal and sagittal) of cervical, thoracic and lumbo-sacral spine were expressed in grades and then summarized. At the same visit the classical BASMI evaluation was performed and VAS (last week), BASDAI and BASFI were applied.
The simple linear regression were performed for BASDAI, BASFI and VAS in the function of AROM and BASMI. The results were expressed as a coefficient of determination (r2) and the level of significance of p<0.05. The data were elaborated by SPSS 12.0.
Results: The AROM was 395±136.4° and BASMI was 3.9±2.3. The Pearson correlation between these tests were r=-0.78 (p<0.000). BASDAI, BASFI and VAS were respectively 41.3±26.2 mm, 30.5±23.7 mm and 27.1±23.2 mm. BASDAI, BASFI and VAS were more correlated with AROM, (respectively r2=0.30, p<0.000; r2=0.39, p<0.000; r2=0.14, p<0.05) than with BASMI (respectively r2=0.09, p=ns; r2=0.24, p<0.01; r2=0.06, p=ns).
Conclusion: AROM was significantly correlated with BASMI. The self-assessed questionnaires were better correlated with AROM than with BASMI. Probably BASMI as a simplify score reflects incompletely the disease activity and functional impairment of AS. We propose that the AROM by IncliMed R may be utilised as an objective method for the evaluation of AS, useful for the research and for clinical trials
Effect of Helicobacter pylori and eradication therapy on gastrointestinal permeability. Implications for patients with seronegative spondyloarthritis
No full textObjective. Disruption of intestinal barrier function, followed by increased antigen load, may possibly trigger joint inflammation. In seronegative spondyloarthritis (SpA) both gut inflammation and altered intestinal permeability have been reported. We evaluated the influence of Helicobacter pylori and nonsteroidal anti inflammatory drugs (NSAID) on gastrointestinal (GI) permeability in SpA. Twenty SpA patients (7 women, mean age 47 +/- 13 SD yrs), 30 patients with endoscopic gastritis (EndG; 17 women, mean age 48 +/- 14 yrs), and 35 healthy controls (16 women, mean age 40 +/- 15 yrs) were studied. No patient was undergoing antisecretory therapy. In the SpA group, 8 patients were chronically taking NSAID and 12 took NSAID occasionally, none during the month before the study. All subjects were assessed for gastroduodenal (sucrose) and intestinal (lactulose/mannitol) permeability test and H. pylori status (urea breath test).
Results. H. pylori affected GI permeability in both SpA and EndG patients. After eradication therapy, sucrose excretion remained increased in SpA and reverted to normal in EndG patients, whereas lactulose/mannitol test became comparable to controls in both groups. SpA patients taking chronic NSAID had increased gastroduodenal permeability only when H. pylori-positive. In SpA patients, GI permeability did not correlate with clinical activity or biochemical inflammation.
Conclusion. In SpA, H. pylori and NSAID contribute to impaired GI permeability. Eradication therapy may help to maintain epithelial barrier function and possibly influence clinical improvement in patients with SpA
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