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Actinomicosi polmonare. Presentazione di un caso clinico e revisione della letteratura
No full textNon disponibil
Flat epithelial atypia on core needle biopsy: which is the right management?
No full textThe clinical significance and management (surgical excision vs. follow-up) of the patients with the diagnosis of flat epithelial atypia (FEA) on core needle biopsy (CNB) are actually under discussion. Using standardized criteria and precise terminology, we analyzed retrospectively our CNB diagnosis of FEA, dividing patients with pure FEA as the most advanced pathologic lesion from patients with FEA associated to atypical ductal hyperplasia (FEA+ADH). Both the categories were correlated with radiologic data and findings on subsequent surgery. We evaluated 875 core needle biopsies (11-gauge stereotactic vacuum-assisted procedure), performed over a 5-year period. A CNB diagnosis of pure FEA was made in 33/875 (3.7%) cases; in other 11 (1.2%) cases we observed the coexistence of FEA and ADH. Subsequent surgical excisions were available in 20/33 pure FEA and in 10/11 FEA+ADH: of the 20 patients with pure FEA on CNB, none had either ductal carcinoma in situ or invasive carcinoma in their excisional biopsy, whereas 3/10 (30%) FEA+ADH on CNB showed, at subsequent surgery, more advanced lesions (2 ductal carcinoma in situ, 1 invasive carcinoma). Our results suggest that patients with an 11-gauge vacuum-assisted CNB diagnosis of pure FEA (especially if related to a small radiologic target, completely or almost completely removed by the needle biopsy procedure) could be spared surgical excision and managed with close radiologic follow-u
Cytodiagnosis in breast pathology: cyto-histological correlations in 129 cases
No full textno abstrac
Nevi blu, schwannomi melanocitari e melanomi con cellule dendritiche, istiociti e linfocito-simili del cuoio capelluto: a proposito di tre casi
No full textLa citologia urinaria nei soggetti sintomatici: confronto cito-istologico su 124 casi. [Urinary cytology in symptomatic subjects: cyto-histological comparison in 124 cases]
No full text[No abstract available
Leiomyosarcoma of the bladder fourteen years after cyclophosphamide therapy for retinoblastoma.
No full textFalse-positive immunostaining of normal epithelia and carcinomas with ascites fluid preparations of antimelanoma monoclonal antibody HMB45
No full textHMB45 is a melanoma-specific monoclonal antibody that has found widespread use in
diagnostic pathology. Recent reports, however, have suggested that this antibody
may cross-react with a small number of carcinomas and other epithelial cells. The
authors tested the hypothesis that these latter reports represent examples of
false-positive immunostaining by comparing the immunostaining on breast, salivary
gland, and lung tumors with the following: (1) a commercial ascites preparation
of this monoclonal antibody; (2) a protein A-purified antibody preparation
derived from ascites fluid; and (3) supernatant fluid obtained from the hybridoma
cell line. The authors found that all examples of nonmelanoma immunostaining in
the carcinomas tested were eliminated with the nonascites fluid preparations,
whereas strong immunostaining of melanomas was retained. The authors conclude
that contaminated commercial ascites fluid preparations of HMB45 may account for
most, if not all, of the reports of nonmelanoma immunostaining with HMB45
[Prognostic value of peritoneal lavage cytology in gastric cancer].
No full textThe microscopic detection of free peritoneal tumour cells in peritoneal lavage fluid in gastric cancer patients is a useful predictor of peritoneal recurrence and poor prognosis. The aim of this study was to verify the prognostic significance of intraoperative peritoneal lavage cytology and its value as a predictor of peritoneal recurrence. We evaluated the presence of free peritoneal tumour cells with extemporary cytological examination in a series of 170 peritoneal washing samples from patients undergoing gastrectomy for gastric cancer over the period from January 1992 to June 2001. Twenty-eight patients (16%) had positive extemporary lavage cytology and there were no false-negatives as compared with the final examination. All patients with positive cytology presented serosal infiltration (T3/T4). Positive peritoneal lavage cytology was a predictor of poor prognosis and peritoneal recurrence: the 24 month survival rate was 17% for positive and 60% for negative cases (P = 0.003); in positive cases 71% of recurrences were located in the peritoneum. Intraoperative cytological examination of peritoneal washings can detect the presence of free malignant cells in the peritoneal cavity and can be used to select patients who may benefit from intraperitoneal chemotherapy
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