86,735 research outputs found
Il carteggio fra Felice Casorati e Angelo Genocchi: rinnovamento scientifico e nuovi approcci didattici nell’Italia post-unitaria - The correspondence between F. Casorati and A. Genocchi: scientific renewal and new teaching approaches
No full textThe aim of this article is to analyse the correspondence between the mathematicians Angelo Genocchi (1817-1889) and Felice Casorati (1835-1890), in order to investigate the impact that they had on the innovation of mathematics teaching and research in Italy after its Unification. The correspondence covers twenty years (1865-1886), with a total of 26 letters, of which 11 were sent by Casorati and 15 by Genocchi, plus a letter from Emil Weyr to Casorati. Recent historiography, which also agrees with the opinion of Vito Volterra, brings out a portrait of Casorati as a man who “lived almost exclusively for his pupils and his school”. The same cannot be said of Genocchi: an innovator, but one to be downplayed, according to other historians. Therefore, it is precisely to shed light on this ambiguity that the analysis of the correspondence with Casorati is inserted, whose topics are solely concerned with teaching and research. It is also intended to highlight how Genocchi’s contribution improved mathematical teaching at the University of Turin, as well as the original results he achieved in number theory. In this regard, after retracing their respective biographies, the panorama of mathematical teaching at the dawn of Unity will be given, without neglecting the Analysis courses they held in Pavia and Turin. Casorati and Genocchi interacted rather well one with another: a first example is the Casorati’s treatise Teorica delle funzioni a variabile complessa to which Genocchi made a notable contribution, and the active commitment of both in supporting excellent young scholars, both for candidacies in competitions and for career opportunities abroad. Finally, evidence from this correspondence will clarify how their divergences in practical approach to the subjects were due to cultural and generational factors, as their objectives are often aligned, at least in their teaching and research intentions
Sociologica. Italian Journal of Sociology Online
No full textBorn in 2007, Sociologica" is an on line journal published in English which offer scholars and students the possibility to discuss quickly and seriously the more relevant topics of the discipline. All the articles submitted are subject to a peer review process. The journal publishes essays - usually followed by invited comments by experts - and shorter articles invited as contributions to edited Symposia. Special attention is devoted to the history of sociology, with the publication of articles which reconstructs past debates about books or issues.
One of the main aims of "Sociologica" is to establish a close dialogue between sociology and society, between sociological knowledge and public debate. This is the intention behind Forefront (Primo Piano), that is built with inputs by the journal's editorial staff and readership, who may react to articles published in the journal by posting their contributions on the website.
The international editorial committe - which includes many of the most influential and respected sociologists in the world - is a guarantee of the high standards of scientific value the journal aims to achieve.
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Edita da una casa editrice prestigiosa come il Mulino, Sociologica è la prima rivista italiana di sociologia completamente on line, e una delle prime a livello internazionale. Sociologica è nata nel 2007 con la volontà di aprire uno spazio pubblico di tipo nuovo, in cui tutti possano discutere, criticare e apprezzare pubblicamente e in modo paritario le diverse questioni che interessano la disciplina sociologica. Le potenzialità dell’on line, infatti, offrono a tutti i membri della comunità sociologica – soprattutto a chi è nelle fasi più delicate e importanti della propria formazione scientifica – l’opportunità di discutere da pari a pari i temi del proprio lavoro di ricerca. Anche per questo la rivista ha scelto di uscire solo nella modalità digitale, pur essendo Sociologica una pubblicazione registrata a tutti gli effetti di legge. Questa modalità permette infatti non solo di scaricare comodamente gli articoli nell’usuale formato pdf o in quello html, ma anche di interagire con la redazione e contribuire in modo diretto e in tempi rapidi alla rivista, inviando commenti e partecipando ai dibattiti che essa periodicamente promuove. Come appare chiaro sia dall’ampio comitato editoriale internazionale, sia dalla scelta di pubblicare anche in inglese, Sociologica non si propone soltanto al pubblico italiano, ma cerca di contribuire al dibattito internazionale: per questo essa ha attivato sin dall’inizio una fitta rete di comunicazioni e di scambi intellettuali con studiosi stranieri, i cui risultati possono apprezzarsi dai contenuti dei primi numeri pubblicat
A murine model of cerebral cavernous malformations with acute hemorrhage
No full textCavernomas are multi-lumen and blood-filled vascular malformations which form in the brain and the spinal cord. They lead to hemorrhage, epileptic seizures, neurological deficits, and paresthesia. An effective medical treatment is still lacking, and the available murine models for cavernomas have several limitations for preclinical studies. These include disease phenotypes that differ from human diseases, such as restriction of the lesions to the cerebellum, and absence of acute hemorrhage. Additional limitations of current murine models include rapid development of lesions, which are lethal before the first month of age. Here, we have characterized a murine model that recapitulates features of the human disease: lesions develop after weaning throughout the entire CNS, including the spinal cord, and undergo acute hemorrhage. This provides a preclinical model to develop new drugs for treatment of acute hemorrhage in the brain and spinal cord, as an unmet medical emergency for patients with cavernomas
Prep1 (pKnox1) transcription factor contributes to pubertal mammary gland branching morphogenesis
No full textPrep1 (pKnox1) is a homeodomain transcription factor essential for in utero and post-natal development and an oncosuppressor gene in human and adult mice. We have analyzed its role in the development of the mouse mammary gland. We used Prep1i/i hypomorphic and Prep1F/F-Ker5CRE crosses to analyze the role of Prep1 in vivo in adult mouse mammary gland development. We also cultured mammary gland stem/progenitor cells in mammospheres to perform biochemical studies. Prep1 was expressed in mammary gland progenitors and fully differentiated mammary gland cells. Using different Prep1-deficient mouse models we show that in vivo Prep1 contributes to mammary gland branching since the branching efficiency of the mammary gland in Prep1-deleted or Prep1 hypomorphic mice was largely reduced. In-vitro, Prep1 sustained functions of the mammary stem/progenitor compartment. Prep1-deficient mammary stem/progenitor cells showed reduced ability to form mammospheres; they were not able to branch in a 3D assay, and exhibited reduced expression of Snail1, Snail2 and vimentin. The branching phenotype associated with increased Tp53-dependent apoptosis and inability to properly activate signals involved in branching morphogenesis. Finally, Prep1 formed complexes with Snail2, a transcription factor essential in branching morphogenesis, and its absence destabilizes and promotes Snail2 proteasome-mediated degradation. We conclude that Prep1 is required for normal adult mammary gland development, in particular at its branching morphogenesis step. By binding Snail2, Prep1 protects it from the proteasomal degradation
Transconductor stage
No full textA transconductor stage for high-frequency filters of a type which comprises an input circuit portion having signal inputs and an output circuit portion, incorporates a pair of field-effect transistors having respective gate and source terminals in common, and has the output portion formed of a pair of bipolar transistors connected to the aforesaid field-effect transistors
A 0.18-um CMOS TIA Plus Limiting Amplifier with a 5.3 GHz Overall Bandwidth for Fiber Optic Communications
No full textA shunt series feedback transimpedance amplifier (TIA), based on a current amplifier using a zero–
pole cancellation, followed by a 6 stages limiting amplifier (LA), proves to be suitable as receiver front-end for a
8 Gb/s communications over fiber optic. The front-end is realized with a 0.18 μm CMOS technology, and shows the
following performances: the TIA has a 50 dB transimpedance gain and 5.5 GHz bandwidth, the LA has a 46 dB
gain and 7.9 GHz bandwidth. The differential voltage swing at the output is 300 mV. The total power consumption
is 112 mW
A 0.18 μm CMOS TIA plus Limiting Amplifier for 8 Gb/s Fiber Optic Communications
No full textA shunt series feedback transimpedance amplifier (TIA), based on a current amplifier using a zero---pole cancellation, followed by a 6 stages limiting amplifier (LA), proves to be suitable as receiver front-end for a 8 Gb/s communications over fiber optic. The front-end is realized with a 0.18 ¿m CMOS technology, and shows the following performances: the TIA has a 50 dB¿ transimpedance gain and 5.5 GHz bandwidth, the LA has a 46 dB gain and 7.9 GHz bandwidth. The differential voltage swing at the output is 300 mV. The total power consumption is 112 mW
Antibiotics counteract the worsening of airway remodelling induced by infections in asthma
No full textAsthma is associated with structural remodelling processes, including basement membrane thickening, increased vascularity and smooth muscle alterations. It is known that respiratory infections are associated with asthma exacerbation; infections can worsen asthma symptoms and influence susceptibility to asthma onset. How infections affect asthma is not fully elucidated. It is possible that the immune response, due to recurrent infections, leads to the pathogen's eradication but also increases bronchial inflammation, which induces airway remodelling in asthmatic subjects. We evaluated how infection affects lung remodelling and inflammatory responses and assessed the impact of antibiotic treatment in a murine model of asthma. Ovalbumin-sensitised BALB/c mice were divided into control, mild and chronic asthmatics. A subset of animals in each group was infected with Streptococcus pneumoniae and was treated with antibiotics. The results show an increase in key lung remodelling factors in mice with chronic asthma, particularly those infected with S. pneumoniae. Notably, antibiotic therapy attenuated these effects. These findings demonstrate for the first time that prompt antibiotic therapy may be useful to reduce lung remodelling progression in infected asthmatic subjects
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