45,536 research outputs found
The Early Pleistocene Equidae from Pirro Nord (Apricena, Southern Italy)
No full textFossil horse remains from Pirro Nord (Southern Italy) are described and compared with the late Early to Middle Pleistocene equids from the main sites of Western and Central Europe (Spain, France, Italy and Germany). Morphological features and dimensions indicate the unequal occurrence of two horses, close in morphology but different in size as supported by the statistical analyses (PCA and DA) performed including the most significant samples of Spain (Venta Micena, Barranco Leon-5, Fuente Nueva-3, Huescar-1, Cullar de Baza-1), France (Soleilhac), Italy (Venosa Loreto, Ponte Galeria), and Germany (Sussenborn, Untermassfeld). The middle-sized horse is identified as Equus altidens altidens VON REICHENAU, 1915, its similarity with to the late early to Early Middle Pleistocene specimens from Guadix-Baza basin and Sussenborn is briefly discussed in order to chronologically assess the Pirro Nord "population". The second species Equus suessenbornensis WUST, 1900, poorly represented, is larger and close to the type population of Sussenborn, as well to the latest Early-early Middle Pleistocene large equids from South-Eastern Spain (Cullar de Baza-1 and Huescar-1), and Italy (Venosa Loreto)
Verdammte Liebe, wie quälst du mich! : Strategie della seduzione nella commedia Die zärtlichen Schwestern di Christian Fürchtegott Gellert
No full textMULTIPLE RAS DOWNSTREAM PATHWAYS MEDIATE FUNCTIONAL REPRESSION OF THE HOMEOBOX GENE PRODUCT TTF-1.
No full textMULTIPLE RAS DOWNSTREAM PATHWAYS MEDIATE FUNCTIONAL REPRESSION OF THE HOMEOBOX GENE PRODUCT TTF-1.
No full textSettling of finite-size particles in isotropically forced, homogeneous turbulence: interface-resolved simulations
No full textWe have simulated the gravity-induced settling of finite-size particles in a turbulent background flow which is forced in a statistically-stationary fashion. The simulations are accurately resolving the solid-fluid interface with the aid of an immersed boundary technique [1]. The parameters of the simulation are (apart from background turbulence) identical to those of reference [2], where particle clustering was observed at a Galileo number of 178 and a solid volume fraction of 0.005. In the present case, it is found that a relative turbulence intensity of 0.24 leads to the disappearance of the clusters; as a consequence, the increase in average particle settling velocity found in [2] also vanishes. [1] M. Uhlmann. An immersed boundary method with direct forcing for the simulation of particulate flows. J. Comput. Phys., 209(2):448–476, 2005. [2] M. Uhlmann and T. Doychev. Sedimentation of a dilute suspension of rigid spheres at intermediate Galileo numbers: the effect of clustering upon the particle motion. J. Fluid Mech., 752:310–348, 2014
The potential role of plant-derived natural products in improving arterial stiffness: a review of dietary intervention studies.
No full textBackground: Arterial stiffness is an early marker of cardiovascular disease. In fact, carotid-femoral pulse wave
velocity, the gold standard method for the evaluation of arterial stiffness, has a positive correlation with cardiovascular
events and mortality. A number of studies have shown that the consumption of different phytochemicals
and plant-derived natural foods can improve arterial elasticity through various molecular mechanisms.
Scope and approach: The principal purpose of this review was to provide a summary of the clinical evidence
provided by different interventional studies on the potential beneficial effects of some natural products and
nutraceuticals on arterial stiffness.
Key findings and conclusions: There is evidence that some foods and food components, including cocoa flavanols,
tea, watermelon, grapefruit, grape juice, berries, cherries, apples, psyllium, tomatoes, garlic, beetroot, melinja,
pistachio, walnut, astaxanthin, curcumin, and safflower seeds assumption are associated with significant improvements
in arterial stiffness in both healthy subjects and subjects with mildly increased cardiovascular disease
risk. Further studies are needed to confirm these promising data
Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management
No full textImpact of Bariatric Surgery on Pulse Wave Velocity as a Measure of Arterial Stiffness: a Systematic Review and Meta-analysis
No full textPurpose: Weight loss during post-bariatric surgery period has been linked to both reduced ASCVD mortality and overall mortality. Atherosclerosis causes arteries to lose their elasticity and become more stiff resulting in increased pulse wave velocity (PWV). It has been revealed that PWV favorably predicts subsequent ASCVDs. The goal of this systematic review and meta-analysis was to see how bariatric surgery affected PWV, an index of arterial stiffness. Materials and Methods: A systematic literature search in four databases was performed. Also, Cochrane guidelines were reviewed to determine bias possibility in the related studies. Comprehensive Meta-Analysis (CMA) V2 software is used to conduct the meta-analysis. Studies were evaluated regarding heterogeneity in design, populations under investigation, and treatment duration using random-effects model and the generic inverse variance weighting approach. A random-effect meta-regression approach was used to investigate the association with the estimated effect size. Evaluation of funnel plot, Egger’s weighted regression, and Begg’s rank correlation tests were utilized to estimate the presence of publication bias in the meta-analysis. Results: The results of meta-analysis on 13 trials including 1426 individuals demonstrated a remarkable decline of PWV after bariatric surgery (WMD: −0.652, 95% CI: −1.004, −0.301, p<0.001). The random-effects meta-regression revealed no evidence of significant correlation between the changes in PWV and initial BMI, BMI changes, or duration of follow-up. Conclusion: The decrease of PWV might be utilized as an independent surrogate marker of improvement of ASCVD risk after bariatric surgery. Graphical abstract: [Figure not available: see fulltext.
- …
