1,721,195 research outputs found
Uso topico di inibitori della tirosina chinasi di origine microbica per prevenire e combattere le patologie dermatologiche da eccesso di proliferazione cellulare
No full textLa presente invenzione riguarda l'impiego del K252, inibitore delle tirosino chinasi, per la preparazione farmaceutica per uso topico nella terapia delle patologie iperproliferative e della psorias
Composizioni contenenti nerve growth factor per la prevenzione del danno prodotto dall'esposizione ai raggi ultravioletti
No full textSi descrivono composizioni cosmetiche e farmaceutiche contenenti NGF per la prevenzione del danno indotto dall'esposizione ai raggi ultraviolett
Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excesssive cell proliferation
No full textThe present invention relates to the use of the alkaloid K252 and its analogues or derivatives to prepare topical drugs for the treatment of disorders characterised by hyperproliferation of keratinocyte
Nerve growth factor and keratinocytes: a role in psoriasis
No full textNerve growth factor (NGF) is synthesized and released by human keratinocytes. NGF acts as a neurotrophic molecule at the skin level, as it stimulates the sprouting of nerve fibers and regulates the synthesis and expression of neuropeptides. NGF can thus take part in neurogenic inflammation which in turn is involved in the pathogenesis of several inflammatory dermatoses. Human keratinocytes also synthesize and express the low (p75)-and the high-affinity (trk) NGF-receptor (NGF-R). NGF stimulates keratinocyte proliferation which is blocked by the natural alcaloid K252, a specific inhibitor of trk phosphorylation. K252 inhibits keratinocyte proliferation and induces keratinocyte apoptosis, in the absence of exogenous NGF, indicating the existence of an autocrine loop where NGF and trk act as key players. Finally, NGF protein levels are increased in psoriatic as compared to nonlesional and normal skin, and psoriatic keratinocytes express higher amounts of NGF than normal keratinocytes. This review will discuss the above findings in view of a possible involvement of NGF in the pathomechanisms associated with the development of the psoriatic lesion
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