1,721,041 research outputs found
A Case Series of Large Volume Iii-Degree Hemorrhoidal Disease: A Special Anatomical Condition Requiring Surgical Treatment
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Optimized MR imaging to characterize hyperplastic process in liver tissue
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The authors report on a null-point fast inversion recovery (IR) technique that was used to evaluate physiological changes in hepatectomized and sham-operated rats. An increase of signal intensity was observed in resected animals, reaching a peak value 24 h after surgery and returning to baseline preoperative values after two weeks. Sham-operated rats did not show a modification of signal intensity. The results indicate that under suitably chosen parameters, an IR sequence is able to detect and characterize the different stages of a hyperplastic process
Increased populations of endocrine cells in Crohn's ileitis
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Hyperplasia of nerves has been described previously in Crohn's disease. To determine whether similar alteration of the enteric endocrine system occurs, endocrine cells of the ileal epithelium were quantified in typical cases of the disease. In the ileum from patients with Crohn's disease, there was an increase in the endocrine cell population, as visualised by immunostaining of chromogranin. Quantification of endocrine cell numbers showed significant increases in both macroscopically uninvolved (i.e. histologically normal) (35.0±3.8, cells per unit length of muscularis mucosae mean ±SEM, P<0.05) and involved (44.5±5.5, P<0.01) Crohn's disease samples, compared with normal controls (23.7±3.4). Although individual types of endocrine cell showed slight increases in Crohn's samples, only the enterochromaffin cells in abnormal bowel showed a significantly greater population (normal controls 10.5±2.3; involved Crohn's 21.3±4.4, P<0.05)
Perianal acquired tufted angioma associated with pregnancy: Case report
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Tufted angiomas are rare lesions described as slowly growing/spreading erythematous macules especially located in the upper trunk and neck. Herein we report the case of perianal location of a tufted angioma in a young pregnant woman. She came to our observation complaining of perianal pain accompanied by bleeding at defecation. A lesion resembling a perianal fissure was observed. Mild hypertonia of the internal sphincter was confirmed at manometry. After one week of ineffective medical treatment, surgery was planned at the end of the sixteenth week under local anaesthesia. The lesion was excised and a minimal sphincterotomy was performed; histopathology report described features of a tufted angioma. The pregnancy proceeded regularly, without anal symptoms, followed by normal vaginal delivery at the thirty-eighth week. This case showed three peculiar features: the association of tufted angioma and pregnancy, the perianal location, and the clinical appearance suggestive of an anal fissure. The clinical manifestation of a perianal tufted angioma, mimicking an anal fissure, is of utmost importance to the differential diagnosis and treatment plan, especially in a pregnant woman
Asymptomatic intestinal lymphangiectasia: Case report [CONSIDERAZIONI SU UN CASO DI LINFANGECTASIA INTESTINALE ASINTOMATICA]
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Primitive lymphangiectasia of the intestine, is a usually symptomatic enteropathy. Asymptomatic forms have been observed, however, characterized by an incidental endoscopic appearance. Asymptomatic lymphangiectasia of the duodenum is believed to be functional and transitory, probably linked to absorption of alimentary fat. Since such condition is extremely rare, no precise classification and pathophysiological explanation are so far available. We observed a case of duodenal lymphangiectasia associated to a lymphangioma of the 4th finger of the left hand. The patient was asymptomatic and no relevant abnormalities of fat metabolism and nutritional status could be detected although the association with a congenital lymphovascular abnormality might suggest the presence of a primitive disease. Interestingly after one year follow-up, endoscopy and histology detected again a picture of duodenal lymphangiectasia. The features of the case that we report here, may suggest that permanent endoscopical/histological aspect may persist also in 'functional', asymptomatic form. Lymphangiectasia may then represent in such cases, a compensatory mechanism following a fatty diet, in order to slow intestinal fat absorption. The association with lymphovascular malformation should be coincidential
Anaphylactic reaction caused by perianal application of glyceryl trinitrate ointment [7] ( Letter )
No full textGut endocrine cell population in coeliac disease estimated by immunocytochemistry using a monoclonal antibody to chromogranin
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Abnormalities of gut endocrine responses, as well as changes in the number of different endocrine cell types, have been reported convincingly in coeliac patients. Nevertheless, no estimation of total numbers of gut endocrine cells has yet been made in well defined groups of coeliacs. In this study, we have visualised all endocrine cell types in jejunal biopsies from coeliac patients with active and quiescent disease as well as in controls, using a monoclonal antibody to chromogranin. This protein was purified originally from bovine adrenal medulla and is known to be a reliable marker for all endocrine cells of the gut. The following groups were considered: (a) nine coeliacs with active illness, (b) 10 coeliacs under gluten-free diet, (c) eight coeliacs receiving gluten challenge, (d) five non-coeliacs (controls). Histological (haematoxylin and eosin) and immunocytochemical (peroxidase anti-peroxidase) stains were applied to 3 μm paraffin sections. Quantitative estimation of endocrine cell density was made using four different methods in order to evaluate the results fully (number of cells/mm2, number of cells/visual field, number of cells/8 crypts-villi, number of cells/unit of length of muscularis mucosae). In patient groups (a) and (c), coeliacs with active disease and coeliacs on gluten challenge diet respectively, a significantly higher number of endocrine cells was observed in comparison with normal controls (group d). In group (b) patients, coeliacs on gluten-free diet, no significant changes in the number of endocrine cells were observed in comparison with controls. Our results show that a significant increase in endocrine cell density exists ion coeliacs with active illness (group a and c), in comparison with controls. This condition is resolved in coeliacs receiving a gluten-free diet (group b)
Enteroglucagon cells of the jejunal mucosa in celiac disease before, during and after dietary treatment (immunohistochemical study) [CELLULE AD ENTEROGLUCAGONE DELLA MUCOSA DIGIUNALE NEL MORBO CELIACO, PRIMA, DURANTE E DOPO IL TRATTAMENTO DIETETICO. STUDIO IMMUNOISTOCHIMICO]
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