1,721,216 research outputs found
Fundaments and clinical value of computer assisted surgery
No full textThe information technologies described in these notes are
not yet fully available to general surgeons but will quickly
develop and translate into products that will become familar
to us in the next generation of our operative rooms. These,
will probably be interventional suites capable of imaging
fusion and navigation technology not only for the benefit of
general surgeons, but for all the different professionals that
already base their treatment modality on images. We do not
need to invent new technology, since most of what is needed
to accomplish this change, and that was described above, has
already been developed or theorized. It is only necessary to
decide how to use existing technology to create new devices
and develop clinical applications for their use that will make
our profession easier to practice and safer for our patients
Development and in vitro testing of a miniature robotic system for computer-assisted colonoscopy.
No full text3D Virtual and physical pancreas reconstruction discriminating between health and tumor tissue with fuzzy logic
No full text
A 3-D mixed-reality system for stereoscopic visualization of medical dataset
No full textWe developed a simple, light, and cheap 3-D visualization device based on mixed reality that can be used by physicians to see preoperative radiological exams in a natural way. The system allows the user to see stereoscopic "augmented images," which are created by mixing 3-D virtual models of anatomies obtained by processing preoperative volumetric radiological images (computed tomography or MRI) with real patient live images, grabbed by means of cameras. The interface of the system consists of a head-mounted display equipped with two high-definition cameras. Cameras are mounted in correspondence of the user's eyes and allow one to grab live images of the patient with the same point of view of the user. The system does not use any external tracker to detect movements of the user or the patient. The movements of the user's head and the alignment of virtual patient with the real one are done using machine vision methods applied on pairs of live images. Experimental results, concerning frame rate and alignment precision between virtual and real patient, demonstrate that machine vision methods used for localization are appropriate for the specific application and that systems based on stereoscopic mixed reality are feasible and can be proficiently adopted in clinical practic
Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver
No full textThe aim of this investigation was to study the methylation of quercetin and fisetin, 2 chemically related flavonoids, in human liver and to this purpose, an assay, was set-up to measure the rates of quercetin and fisetin methylation in human liver. The methylation rates (pmol/min/mg) Of quercetin and fisetin were measured in 10 liver samples and the mean +/- SD and the median were 170 +/- 30 and 177 (quercetin) and 183 15 and 178 (fisetin). The rates of quercetin and fisetin methylation were not different (p = 0.283). The fold of variation among samples as 2 (quercetin) and 1.3 (fisetin). Methytransferase towards quercetin and fisetin followed Michaelis-Menten kinetics, and the K-m values were 2.6 +/- 0.3 (quercetin) and 8,6 +/- 0.7 muM (fisetin. p = 0.009) and the V-max values were 187 +/- 20 (quercetin) and 276 +/- 33 pmol/min/mg (fisetin, p = 0.009). Two. 4 and 8 mul of red Chianti wine added to the incubation mixture reduced the rate of quercetin methylation to 75 +/- 4%, 65 +/- 9% and 59 +/- 9%, respectively, and that of fisetin methylation to 62 +/- 3%, 51 +/- 3% and 44 +/- 4%. respectively. In conclusion. quercetin and fisetin are methylated in human liver and their rates of methylation have a limited variation among subjects
A micro/nanoscale surface mechanical study on morpho-functional changes in multilineage-differentiated human mesenchymal stem cells.
No full textIn recent years MSCs have become a very attractive tool in tissue engineering and regenerative medicine because of their ability to be committed along several lineages through chemical or physical stimuli. Nevertheless their therapeutic potential and plasticity are not yet totally understood. This report describes the use of AFM together with conventional microscopies to obtain mechanical information on cell surfaces and deposited extra cellular matrix molecules, after inducing the differentiation of human MSCs towards three typical mesoderm phenotypes. The aim is to correlate morphological, functional, and mechanical aspects of human MSCs to obtain a deeper understanding of their great potential
Intraoperative cholangiography during laparoscopic cholecystectomy. Routine vs selective policy.
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