1,721,056 research outputs found
Membrane electrical properties of skeletal muscle fibres from dystrophic mice: a pharmacological approach
No full textATP sensitive K+ channels of skeletal muscle fibers from K+ depleted rats, an animal model of human HOPP
No full textModulators of K-ATP channels improve macroscopic and single channel abnormalities occurring in the animal model of hypokaliemic periodic paralysis
No full textExcitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse
No full textHypertriglyceridemia Therapy: Past, Present and Future Perspectives
Full text linkHypertriglyceridemia therapy is essential for preventing cardiovascular diseases. Fibrates belong to an important class of lipid-lowering drugs useful for the management of dyslipidaemia. By acting on the peroxisome proliferator-activated receptor (PPAR)-α, these drugs lower serum triglyceride levels and raise high-density lipoprotein cholesterol. Fibrate monotherapy is associated with a risk of myopathy and this risk is enhanced when these agents are administered together with statins. However, whereas gemfibrozil can increase plasma concentrations of statins, fenofibrate has less influence on the pharmacokinetics of statins. Pemafibrate is a new PPAR-α-selective drug considered for therapy, and clinical trials are ongoing. Apart from this class of drugs, new therapies have emerged with different mechanisms of action to reduce triglycerides and the risk of cardiovascular diseases
Biochemical and electrophysiological evidence for a role of insulin-like growth factor in the spontaneous regeneration of dystrophic mdx mouse
No full textAge-dependent modification of phosphorylation state of skeletal muscle chloride channel controls its biophysical and pharmacological properties
No full textEffect of growth hormone administration on ionic conductances and excitability characteristics of skeletal muscle from aged rats
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Growth hormone improves the lowered chloride conductance of rat skeletal muscle during aging
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