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    EFFECTS OF FRUCTOSE 1-6 DIPHOSPHATE ON HEART RATE, VENTILATION, OXIGEN CONSUMPTION AND ENDURANCE PERFORMANCE

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    A controlled study was carried out in 12 healthy male volunteers to evaluate the effects of fructose-1,6-diphosphate (FDP) on cardiac and respiratory parameters and work capacity during maximal muscular exercise on a cycloergometer. Each subject was studied in 3 sessions, separated by at least 36 hours. Workload started at 50 watts with stepwise increases, consisting of 25 watts every 3 minutes, up to muscular exhaustion or until the predicted maximum heart rate was attained. The first session, with no treatment, served as the control test; in the other two sessions, each subject received, prior to exercising, a single intravenous dose of either 7.5 g dextrose or 15 g FDP, according to a within-subject comparative study design. In resting conditions and during the exercise, heart rate, ventilation (VE), and oxygen consumption (VO2) were monitored. At the end of each session, the total work (TW) performed and the maximum oxygen consumption (VO2 max) were computed. No difference was found between the values obtained in the control and dextrose treatment sessions. The increments in heart rate, VE and VO2 at each workload observed after FDP treatment were lower (p less than 0.01) than those in control and dextrose sessions. A 25% increase in TW associated with a 12% increase in VO2 max was observed after FDP (p less than 0.01). The data indicate that FDP is potentially capable of improving muscular performance, and several possible mechanisms of action for the observed effects are discussed

    DANTROLENE SODIUM IN TRAUMATIC MUSCLE CONTRACTURE;DOUBLE-BLIND CLINICAL AND PHARMACOLOGICAL TRIAL

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    Thirty athletes with muscular contractures were enrolled in a double-blind study of dantrolene sodium and placebo to evaluate the decontracture activity and tolerance of the drug after eight days of treatment. The efficacy of the drug was assessed by studying pain at rest, during movement, and during pressure, as well as muscular tension and functional recovery. Twenty-eight patients completed the study. At the end of treatment, a decrease in pain was observed at rest (71.4% of patients treated with dantrolene and 21.4% of placebo-treated patients), during movement (78.6% and 35.7%, respectively), and during compression. The most noticeable effects were seen in the reduction of muscular tension (100% in the patients treated with dantrolene sodium and 35.7% in the placebo-treated patients) and in functional recovery (100% and 28%, respectively). In addition to the clinical study, an evaluation of the effects of dantrolene and placebo on overall performance and on the action of the respiratory system was conducted with six healthy subjects by means of basal respiratory measurement and ergospirometry before and after single-dose treatment. This study showed that dantrolene sodium is useful in the treatment of traumatic contracture, and that it does not alter an individual's overall performance. Dantrolene sodium represents a valid treatment to accompany analgesic, anti-inflammatory, and rehabilitation therapy of posttraumatic lesions in athletes
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