1,721,281 research outputs found

    Stress echo in microvascular disease

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    Coronary microcirculation is a fundamental portion of the coronary artery tree, as it contains most of the coronary blood volume and represents the main regulator of the coronary blood flow. Arterioles, capillaries, and venules originating from the major coronary artery branches and extending inside myocardium, with a diameter less than 300 μm, constitute the whole coronary microcirculation. While in the past only epicardial segments of coronary arteries were recognized to be potentially diseased by atherosclerotic process, in the last years growing evidences have suggested that some impairment may also affect the microcirculation. Interestingly, coronary microvascular impairment greatly contributes to pathophysiology of many cardiac diseases and to patient prognosis. As worth of note, different degrees of coronary microvascular impairment can be found both with and without epicardial obstructive atherosclerosis: indeed, recently, coronary microvascular abnormalities have been described in patients with normal coronary angiograms. Several conditions can be clustered together in the syndrome of microvascular disease (Table 30.1) [1]. In some of these conditions, the abnormalities of the microvasculature represent important markers of risk and may even determine myocardial ischemia, thus becoming important therapeutic targets [1]

    The risk of cumulative radiation exposure in chest imaging and the advantage of bedside ultrasound

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    The increasing use and complexity of imaging techniques have not been matched by increasing awareness and knowledge by prescribers and practitioners. Imaging examinations that expose to ionizing radiation provide immense benefits when appropriate, yet they may result in an increased incidence of radiation-induced cancer in the long-term. The radiation issue is relevant not only for the individual patient but also for the community because small individual risks multiplied by millions of examinations become a significant population risk. As recently highlighted by recent European and American Guidelines, the long-term risk associated with radiation exposure should be considered in the risk-benefit assessment behind appropriate prescription of diagnostic testing
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