1,721,449 research outputs found
L'asma nella realtà di tutti i giorni
No full textRevisione sulla rilevanza dell'asma nella vita del bambino e dell'adolescent
The potential roles of leukotrienes in bronchial asthma
No full textLeukotrienes (LTs), in particular LTC4, LTD4, and LTE4, have been shown to be capable of participating in the induction of three related processes observed during the immediate reaction in bronchial asthma: edema formation, mucus secretion, and muscle contraction. Despite impressive evidence potentially implicating the LTs, the role of LTs in asthma is still unproved, and a positive answer to their critical actions in causing airflow obstruction will require studies with specific antagonists
Differential diagnosis in bronchial asthma.
No full textAlthough asthma is consider the most common condition presenting with wheezing, not all children who wheeze are affected by asthma
Cystic fibrosis patients, infertile men, and their noses.
No full textThe paper is an editorial on the role of nasal investigation in the diagnosis of cistic fibrosis
Inhaled corticosteroids in children. Is there a 'safe' dosage?
No full textInhaled corticosteroids are effective for the treatment of asthma. Because of the appreciation of the importance of airway inflammation in the pathogenesis of the disease, these drugs are being used more frequently not only in severe but also in moderate asthma. Treatment rarely has to be stopped because of topical adverse effects since oropharyngeal candidiasis and dysphonia are uncommon in children. However, paediatricians need to remain alert for the possibility of systemic adverse effects. With sensitive techniques, dose-dependent adrenal suppression has been documented in children treated with inhaled steroids but generally this effect has no clinical relevance. Although suppression of short term growth velocity has been reported, long term studies have shown that when growth impairment occurs in a child with asthma it is more likely to reflect poor asthma control than the administration of inhaled corticosteroids. Calcium supplementation may be necessary in children with asthma treated with inhaled steroids since this treatment may cause reduction in osteocalcin, a marker of osteoblast activity and bone formation. Other systemic adverse effects have been reported in case reports. The use of a large spacer device has been shown to reduce the incidence of both topical and systemic adverse effects from inhaled steroids and their use should be encouraged. In any child with asthma who really needs inhaled steroids, the lowest dose possible should be prescribed; however, the mistake of prescribing doses too low to be therapeutically effective should be avoided
Global Initiative for Asthma 2021: Asthma in Preschool Children and Short-Acting β2-Agonist-Only Treatment
Full text linkwe suggest that the GINA recommendation for children >6 years old that low-dose ICS be taken whenever SABAs are taken should apply to preschool-aged children as wel
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