177,171 research outputs found
Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer.
No full textThe third-generation aromatase inhibitors (AIs), letrozole, anastrozole and exemestane, are becoming the first choice endocrine drugs for post-menopausal women with breast cancer, since they present greater efficacy when compared with tamoxifen in both adjuvant and metastatic setting. In particular, several large and well designed trials have suggested an important role for AIs in the adjuvant treatment of postmenopausal women with estrogen-receptor positive breast cancer either in the upfront, sequential or extended adjuvant mode. Overall, AIs are associated with a small but significant improvement in disease free survival. The expanding use of AIs in the treatment of early breast cancer means that individual patients will be exposed to the agents for longer durations, making it increasingly important to establish their long-term safety. This review focused on the effects of AIs on bone metabolism, serum lipids and cardiovascular risk. AIs have adverse effects on bone turnover with a reduction of bone mineral density and an increase in the rate of fragility fractures. With respect to tamoxifen AIs present lower thrombotic risk and a less favorable impact on lipid profile, whereas the true effects on cardiovascular risk still remain to be clarified. An adequate monitoring of bone mineral density (BMD) and lipid profile could be recommended for post-menopausal women candidate to AIs
Visita di Robin Kravets (UIUC)
No full textcollaborazione scientifica su assisted leaving, wireless sensor networks per health monitoring01/09/200
ALBA-R: Load-Balancing Geographic Routing Around Connectivity Holes in Wireless Sensor Networks
No full textThis paper presents ALBA-R, a protocol for convergecasting in wireless sensor networks. ALBA-R features the cross-layer integration of geographic routing with contention-based MAC for relay selection and load balancing (ALBA), as well as a mechanism to detect and route around connectivity holes (Rainbow). ALBA and Rainbow (ALBA-R) together solve the problem of routing around a dead end without overhead-intensive techniques such as graph planarization and face routing. The protocol is localized and distributed, and adapts efficiently to varying traffic and node deployments. Through extensive ns2-based simulations, we show that ALBA-R significantly outperforms other convergecasting protocols and solutions for dealing with connectivity holes, especially in critical traffic conditions and low-density networks. The performance of ALBA-R is also evaluated through experiments in an outdoor testbed of TinyOS motes. Our results show that ALBA-R is an energy-efficient protocol that achieves remarkable performance in terms of packet delivery ratio and end-to-end latency in different scenarios, thus being suitable for real network deployments
A Performance Comparison of Scatternet Formation Protocols for Networks of Bluetooth Devices
No full textALBA-R: Load-Balancing Geographic Routing Around Connectivity Holes in Wireless Sensor Networks
No full textThis paper presents ALBA-R, a protocol for convergecasting in wireless sensor networks. ALBA-R features the cross-layer integration of geographic routing with contention-based MAC for relay selection and load balancing (ALBA) as well as a mechanism to detect and route around connectivity holes (Rainbow). ALBA and Rainbow (ALBA-R) together solve the problem of routing around a dead end without overhead-intensive techniques such as graph planarization and face routing. The protocol is localized and distributed, and adapts efficiently to varying traffic and node deployments. Through extensive ns2-based simulations we show that ALBA-R significantly outperforms other convergecasting protocols and solutions for dealing with connectivity holes, especially in critical traffic conditions and low density networks. The performance of ALBA-R is also evaluated through experiments in an outdoor testbed of TinyOS motes. Our results show that ALBA-R is an energy-efficient protocol that achieves remarkable performance in terms of packet delivery ratio and end-to-end latency in different scenarios, thus being suitable for real network deployments
Performance Evaluation of a New Scatternet Formation Protocol for Multi-hop Bluetooth Networks
No full textEpirubicin alone or Epirubicin + ifosfamide as adjuvant chemotherapy in soft tissue sarcomas
No full text
Performance evaluation of underwater MAC protocols: at-sea experiments
No full textIn this paper, we investigate the performance of three medium access control (MAC) protocols (CSMA, T-Lohi, and DACAP) representing simple, intermediate, and fully negotiated protocols, to access the underwater acoustic channel, during two at-sea campaigns. Various tests were conducted in the waters surrounding Pianosa island during the NATO ACommsNet10 experiment in September 2010 and off the coast of the Palmaria island during the NATO CommsNet13 experiment in 2013. Different types of application loads and communication devices have been used to investigate the performance of the various protocols under different transmission rates and introduced overhead. The presence of more stable and reliable communication links and of a highly dynamic communication channel has also been explored. The collected results show that there is no single solution that is best for all the possible scenarios and configurations and that the selection of different protocols is required for different contexts. This highlights the importance of understanding the performance of each protocol at sea, under various conditions, to design novel and adaptive schemes, which are able to react in an efficient and effective way to possible changes in the network and in the communication channel
Localization Error-resilient Geographic Routing for Wireless Sensor Networks
No full textThis paper concerns the demonstration of the resilience to localization errors of ALBA-R, a protocol for geographic routing in wireless sensor networks (WSNs). In particular, we show that thanks to a simple yet effective nodal coloring mechanism for handling nodal connectivity holes, ALBA-R achieves the further desirable benefit of being totally resilient to localization errors, which are unavoidable in WSNs. Via ns2- based simulations we show that independently of fundamental network parameters such as network density, and also independently of errors in nodal coordinate estimations as high as the node transmission radius, ALBA-R is successful in delivering all generated packets while incurring reasonable degradation for metrics such as route-length and end-to-end latency and still remaining and energy efficient protocol. © 2008 IEEE
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