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    FUNCTIONAL EVALUATION OF HEPATIC PARENCHYMA WITH DYNAMIC TESTS (INDOCYANINE GREEN AND HIPPURATE RATIO) IN PATIENTS WITH HCC

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    Our aim was to assess hepatic functionality in patients with HCC and candidate for liver resection. We used dynamic tests of liver functionality Indocyanine green (ICG) and Hippurate ratio, for the evaluation of surgical risk and postoperative clinical course. The clinical and predictive value of the tests has been compared with each other and with routine tests. Tests have been performed on 11 patients with HCC, in 8 before surgery and after 6 months, in 1 before TACE and after 6 months. The results showed a significative correlation with the endpoints: survival, liver failure, general condition of the patients, and parallelism in the clinical assessment of patients. ICG and Hippurate ratio are useful in patients undergoing liver resection and in the follow up.“SAPIENZA” UNIVERSITY OF ROM

    Cure termali nella terza età

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    The authors summarize the properties of the mineral waters and list the main therapeutic uses and doses. They outline the role of spa therapy in the diseases and illness of elderly, namely in chronic degenerative ones. The employ of muds and balneotherapy in chronic arthropaties of elderly is stressed

    Gout and related morbid conditions: Pharmacological and SPA therapy

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    Gouty arthritis is estimated to be the most frequent manifestation of inflammatory arthritis in men aged over 40. Hyperuricemia occurs because of both exogenous and genetic factors, which are particularly influential in some populations such as Taiwan aborigines. Current understanding of the disease etiopathogenesis, its clinical manifestations and the stages of its progression are presented here. The criteria for a correct diagnosis of the disease are also reported, pointing out how to distinguish gout from clinical events of different origin but with a very similar symptomatology. A distinction is made between the agents used to relieve the acute attack (colchicine, nonsteroidal anti-inflammatory drugs, corticosteroids) and those used with the purpose of correcting hyperuricemia and preventing recurrences and complications (allopurinol, uricosurics). Mechanisms of action, administration routes, doses, side effects and contraindications of every drug are described. Besides pharmacological therapy, the importance and the efficacy of spa therapy is underlined. Finally, perspectives opened by gene therapy are mentioned

    Spa therapy in urolithiasis [Cure termali nella calcolosi urinaria]

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    In the present paper we remind epidemiology, etiopathogenesis and physiopathology of urolythiasis, emphasizing the role of lythogenic and antilythogenic urinary costituents. Mineral waters used in prevention and therapy of urolythiasis are described, namely oligomineral waters and, in uric lythiasis, bicarbonate mineral waters. We stress the activity of oligomineral waters, regarding their very low concentration of solute, presence of oligoelements, and antilythogenic components. At the end, we outline the role of spa therapy in the correction of metabolic disorders, which are etiologic and pathogenetic factors of urolythiasis

    SPA treatments of diseases pertaining to internal medicine

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    Authors resume the therapeutic employments of mineral waters, muds and baths in internistic syndromes or diseases. Mineral waters are used in the therapy of functional dyspepsia, gastro-oesophageal reflux, chronic primary stipsis, irritable bowel, biliary dyskinesias, mainly hypokinetic gallbladder and Oddi's sphincter, spasm, postcolecystectomy syndrome. The therapeutic effects of mineral waters are determined by their anion and cation content, the presence of undissociated salts and also by the presence of oligoelements. Additionally, the effects of a mineral waters are connected with physical constants: osmotic pressure and temperature. Many researches showed activity of the mineral waters on intestinal autonomic nerves and plexus (CIA), motility, exocrine, endocrine and paracrine digestive secretions and therapeutic properties belonging to evidence based medicine. Mud and bath therapy are effective in treatment of osteoartrhitis. During and after mud-therapy effects on diencephalic-pituitary-adrenal axis were displayed, producing increase of endogenous opioids and cortisol. Clinical controlled trials showed significant improvement of symptoms as pain and stiffness. Inhalant therapy by sulphureous and salsojodic mineral waters improve symptoms as cough and escreate and functional indices as FEV1 in chronic obstructive pulmonary disease. The oligomineral waters are very useful in the treatment and secondary prevention of urolithiasis and of relapses of urinary stones after spontaneous expulsion, surgical treatment, stones removal by percutaneous or uretheroendoscopic treatment and lithotrypsia. Patients must drink at least 2L every day, substantially for ever. Chlorurate-sodic and bicarbonate mineral waters show improevement in disorders of lipidic and urate metabolism. Clin Ter 2010; 161(2):e63-e7

    Water, mineral waters and health

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    The authors focus on water resources and the use of mineral waters in human nutrition, especially in the different stages of life, in physical activity and in the presence of some morbid conditions. Mineral water is characterized by its purity at source, its content in minerals, trace elements and other constituents, its conservation and its heating properties recognized by the Ministry of Health after clinical and pharmacological trials. Based on total salt content in grams after evaporation of 11 mineral water dried at 180 degrees C (dry residues), mineral waters can be classified as: waters with a very low mineral content, waters tow in mineral content, waters with a medium mineral content, and strongly mineralized waters. Based on ion composition mineral waters can be classified as: bicarbonate waters, sulfate waters, sodium chloride or saltwater, sulfurous waters. Based on biological activity mineral waters can be classified as: diuretic waters, cathartic waters, waters with antiphlogistic properties. Instructions for use, doses, and current regulations are included. (C) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved
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