1,721,270 research outputs found
MECCANISMI ED EFFETTI DELLA RISPOSTA AL DANNO DEL DNA NEL CUORE E NUOVI APPROCCI MOLECOLARI PER POTENZIARE IL RIPARO NEI CARDIOMIOCITI
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Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure
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Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure
No full textHuman heart failure is a complex clinical syndrome characterized by extensive abnormalities in the beta-adrenergic receptor (betaAR) system. Normalization of betaAR signalling consistently ameliorates cardiac dysfunction and survival in heart failure, suggesting that betaAR dysfunction may be intrinsically linked to the deterioration of cardiac performance. Agonist-dependent phosphorylation of betaARs by betaAR kinase 1 (betaARK1) initiates the processes of desensitization and downregulation, hallmarks of heart failure. Our recent studies have shown that betaARK1 forms a cytosolic complex with phosphoinositide 3-kinase (PI3K) and that translocation of betaARK1 to the plasma membrane also promotes the betaAR-targeting of PI3Ks. At the plasma membrane, the generation of 3'-phosphorylated phosphatidylinositols by PI3K is required in the process of endocytosis, a prodrome to receptor downregulation. A large body of data now indicates that betaAR-targeting of PI3Ks is consistently associated with abnormalities of betaAR signalling under pathological conditions, including pressure-overload hypertrophy and heart failure from different causes. In this review we will discuss the role of betaAR-targeted PI3K activity and novel experimental strategies to disrupt the betaARK1/PI3K complex and in turn ameliorate betaAR dysfunction and the progression of heart failure
Chemical characterization of indoor and outdoor fine particulate matter in an occupied apartment in Rome, Italy
No full textThe daily concentration and chemical composition of PM2.5 was determined in indoor and outdoor 24-h samples simultaneously collected for a total of 5 weeks during a winter and a summer period in an apartment sited in Rome, Italy. The use of a specifically developed very quiet sampler (<35 dB) allowed the execution of the study while the family living in the apartment led its normal life. The indoor concentration of PM2.5 showed a small seasonal variation, while outdoor values were much higher during the winter study. Outdoor sources were found to contribute significantly to indoor PM concentration especially during the summer, when the apartment was naturally ventilated by opening the windows. During the winter the infiltration of outdoor PM components was lower and mostly regulated by the particle dimensions. Organics displayed In/Out ratios higher than unity during both periods; their indoor production increased significantly during the weekends, where the family stayed mostly at home. PM components were grouped into macrosources (soil, sea, secondary inorganics, traffic, organics). During the summer the main contributions to outdoor PM2.5 came from soil (30%), secondary inorganics (29%) and organics (22%). Organics dominated both indoor PM2.5 during the summer (60%) and outdoor and indoor PM2.5 during the winter (51% and 66%, respectively)
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