1,721,295 research outputs found
Considerations on the role of chemotherapy and modern radiotherapy in the treatment of childhood low grade glioma
No full textAbstract
The treatment of childhood low grade glioma (LGG), if not amenable to complete resection, quite often is a relevant clinical challenge. LGG in many instances are indeed slow growing tumors, which, if not controlled, can cause severe morbidity and ultimately jeopardize life. Most of the time children bearing an unresectable LGG can be considered affected by a chronic disease, deserving protracted cures. The treatment philosophy, which has dictated the treatment of malignant cancers, has also inspired the therapeutic concepts for managing childhood LGG. However, it is getting more and more evident that different strategies are needed for them. LGG represent a highly heterogeneous group of neoplasm and comprehensive treatment concepts rarely meet the individual patient's needs. After more than 20 years of clinical research it can be stated with confidence that for unresectable, progressive LGG, chemotherapy (CT) represents an effective treatment modality. It delays tumor growth and postpones the use of radiotherapy (RT), thus sparing the deleterious effects of irradiation on a developing brain. However, CT rarely cures LGG and definitively obviates the need of RT or aggressive surgery. Furthermore, little is known on the actual impact of CT on patients' overall health status. Recent progresses in RT delivering techniques, which allow reducing the safety margins, are tempering the concerns related to the use of this treatment modality in children. This manuscript reviews and expands these data, trying to combine them in a coherent picture that it is hoped can help in directing future research in this field
Guidelines for integrated activity between pediatric Hematology-Oncology nurses and physicians.
No full textGuidelines for integrated activity between pediatric hematology-oncology nurses and physicians. Doctor-Nurse Integrated Workgroup of the Italian Association of Pediatric Hematology and Oncology (AIEOP
Commentary on: “The response and survival of children with recurrent diffuse intrinsic pontine glioma based on phase II study of antineoplastons A10 and AS2-1 in patients with brainstem glioma.” By Burzynski et al.
No full textTU E LA LEUCEMIA GIORNO DOPO GIORNO
No full textOPUSCOLO INFORMATIVO PER I GENITORI DI BAMBINI AFFETTI DA LEUCEMI
Tumors of CNS in infants and children
No full textOverview of present knolwedge on childhood brain tumor
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