1,721,016 research outputs found
Technological process to manufacture ceramic microelectrodes for biomedical applications implying microextrusion of pre-ceramic resins
No full textBest Poster Awar
Nanogel functionalization: a versatile approach to meet the challenges of drug and gene delivery
Full text linkTrends in regenerative therapies, combination approaches, and clinical highlights for spinal cord injury (SCI) regeneration
Full text linkCOMPOSITE CUSTOM-MADE BONE GRAFTS (SMARTBONE® ON DEMANDTM) FOR A LARGE SPHENO-ORBITAL RECONSTRUCTION
Full text linkThe treatment of anterior and lateral skull base tumors has always constituted a complex surgical challenge: extensive bony demolitions produce aesthetic deformities that need accurate reconstructions. Indeed, highly destructive procedures increased the need to introduce new reconstructive techniques. Wide defects, e.g. those involving more than a single orbital wall, have to be reconstructed with solid tissues such as autologus grafts or alloplastic materials. Surgical visual limits may reduce the possibility to properly repair the three-dimensional bony architecture of the craniofacial skeleton: because of the nonlinear nature of the bone in the craniofacial skeleton, even small degrees of error can lead to poor outcomes.
Here we investigated the innovative application of custom-made bone grafts in a case of skull base reconstructive surgery, a technique that is not previously reported. Innovations applied to this case were multiple: basing on high resolution patient’s CT scans, virtual surgery and computer-aided design were used to plan resection; contralateral disease-free skull base was used as a reference and mirroring technique was used to create the ideal grafts, which were then manufactured accordingly using the new composite custom-made bone grafts (SmartBone® on DemandTM). SmartBone® is shaping resistant and offers high tenacity to screws and surgical fixation manoeuvres, because it is produced by combining bovine mineral bone structures with biopolymers and cell nutrients (polysaccharides).
The patient underwent resection of a meningioma in the spheno-orbital-temporal region. The neurosurgeon resected the meningeal involved district, which was then reconstructed with a collagenous membrane. SmartBone® on DemandTM were then very precisely grafted into destination site. During follow-up, nor cerebrospinal fluid leakage nor intracranial infection were registered. Postoperative CT scans showed excellent stability and integration of all bone grafts; postoperative morphological results are satisfactory.
Outcomes confirm the high reliability and accuracy of virtual surgical planning and grafts design, which, together with SmartBone® high performances, allow producing very precise and stable custom-made grafts and, finally, addressing the previously unmet needs in skull base reconstructive surgery
Extruded ceramic microelectrodes for biomedical applications obtained from pre-ceramic polymeric precursors
No full textClinical and histological evaluation of socket preservation using smartbone®, a novel heterologous bone substitute: A case series study
No full textObjectives. The aim of this case series study was to evaluate, clinically and histologically, the performances of a novel composite xenohybrid bone substitute. Methods. Ten non-restorable teeth were extracted and socket preservation was performed with a bovine heterologous graft enriched with collagen and resorbable biopolymers (SmartBone®). The socket was covered with a collagen membrane firmly sutured. After five months of healing, implant site was prepared by means of a trephine bur and a dental implant was inserted. Specimens were sent for histological analysis. After three months of healing, patients received a provisional restoration followed by a definitive crown. Results. All socket preservations healed uneventfully and, after five months, it was possible to insert implants with no additional bone augmentation procedures. All placed implants osseointegrated successfully and were in function after a minimum follow-up period of 30 months. Conclusions. The tested biomaterial confirmed good clinical performance and, even if left exposed to the oral cavity covered with a collagen membrane, did not show signs of infection. Further research is desirable with a larger sample and variations of socket preservation technique to better understand the potential of this novel bone substitute
Scaffold for tissue regeneration, particularly for bone regeneration, and manufacturing method thereof.
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Scaffold for tissue regeneration, particularly for bone regeneration, and manufacturing method thereof.
No full text- …
