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    Ultrasonic backscatter of the carotid wall in young and older athletes

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    Objectives. The aim of this study was to evaluate the effects of habitual exercise on the age-related changes of carotid wall composition defining its acoustic reflectivity by the quantitative approach of integrated backscatter (IBS) analysis. Desing. Cross-sectional study. Setting. University Hospital. Subjects. Fifty-four competitive long-distance runners (males, age range 22-72 years) and 50 healthy sedentary controls. Main outcome measures. All the subjects underwent both 2-D conventional ultrasonography and IBS analysis. IBS values were sampled from a region of interest (ROI) placed within five consecutive regions of the common carotid intima-media, and then corrected (C-IBS) for the IBS value of the adventitia. Results. Athletes showed a lower C-IBS (-27.07 +/- 2.9 dB vs. -24.57 +/- 4 dB, P 60 years of age) tertile of age, we assess the influence of age on IMT and IBS. Sedentary older individuals exhibited an IMT higher respect to young controls and to the both trained subgroups (P < 0.0001). C-IBS was lower in both subgroups of athletes, independently of age, and lower in sedentary young people respect to sedentary older subgroup (P < 0.0001). Endurance chronic exercise blunted the difference of C-IBS observed between young and older sedentary individuals. Moreover, C-IBS was positively related to age (r = 0.77, P < 0.0001) and IMT (r = 0.52, P < 0.0001). Conclusions. The age-related changes of the arterial wall are attenuated by physical training. These modifications can be quantitatively discriminated by ultrasonic backscatter method

    Ultrasonic tissue characterization of the myocardium in anorexia nervosa

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    Aim: To determine the systodiastolic variations in the integrated backscatter (IBS) signal of the myocardium in patients with anorexia nervosa. Methods: 25 young wornen (aged 22.4 +/- 4.3 y) with overt anorexia nervosa, compared with 25 age-matched thin and 25 age-matched control women with body mass index >20 kg m(-2), underwent either conventional two-dimensional echocardiography or analysis of IBS cyclic variations. Results: Compared with thin and control subjects, anorectic patients showed reduced left ventricular mass (LVM: 82.9 +/- 17.1 vs 119.9 +/- 13.8 and vs 126.12 +/- 16.4 g, p < 0.0001; LVM indexed 21.4 +/- 3.3 vs 29.4 +/- 2.5 and vs 31.2 +/- 3.1 g m(-2.7), p < 0.0001), and IBS cyclic variations (septum: -0.49 +/- 2.18 vs 6.86 +/- 1.3 and vs 6.61 +/- 1.74 dB, p < 0.0001; posterior wall: 2.77 +/- 2.12 vs 7.15 +/- 2.12 and vs 7.48 +/- 2.23 dB, p < 0.01). Conclusion: Anorexia nervosa is associated with a significant reduction in the cyclic variation in IBS, which is also related to left ventricular hypotrophy. Ultrasonic tissue characterization could give an objective approach for the detection of myocardial structural properties and represent a preclinical index of myocardial dysfunction in anorexia nervosa
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