1,720,975 research outputs found

    Stile di vita e fibrillazione atriale

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    Lifestyle factors, in particular dietary intake, have been recognized as important, modifiable risk factors for cardiovascular disease. Consuming a heart-healthy diet lowers the individual’s risk for CVD. Data on relationship between lifestyle and atrial fibrillation are controversial, however the strong association between obesity, atrial/ventricular dysfunction and a non-healthy lifestyle and atrial fibrillation, suggests that correction of nutritional habits could prevent the development of arrhythmias through reduction of underline cardiac diseases. Today the Mediterranean diet is considered one of the best in term of prevention of cardiovascular disease

    Caffeine, Energy Drinks and Atrial Fibrillation: A Mini-Review

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    The present mini-review analyzes the relationship between caffeine and atrial fibrillation (AF) and specifically referred to the association between energy drinks (EDs) and occurrence of AF. The topic is very actual whereas data in literature are controversial. The quantity of caffeine in EDs is really high and is often underestimated by users. Several case-reports suggested a risk of AF in subjects assuming high quantity of EDs and it is becoming a social problem due to the wide use of mix drinks (EDs and alcohol) among youth

    Energy drink overconsumption can trigger atrial fibrillation

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    Many adverse cardiac effects have been reported follow- ing energy drinks consumption, among which atrial arrhythmias, acute coronary syndromes, and even cardiac arrest. These can develop also in the absence of other symptoms related to acute toxicity, such as neurological symptoms. Considering the absence of specific toxico- logical tests, the diagnosis of energy drink intoxication still remains clinic

    Platelet Activation in Extracorporeal Circulation: Effects of Unfractionated Heparin on Damages Induced by Bio-incompatibility

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    Background. Interaction with biomaterials of non-endothelial surfaces of cardiopulmonary bypass circuit caused platelets activation.The aim of study was to evaluate the effects of unfractionated heparin (UH) on platelet activation induced by extracorporeal circulation (ECC). Methods. Analysis were performed on peripheral human blood (PB) obtained from 10 healthy adult blood donors.Markers were evaluated after in-vitro and after ECC stimulation, samples with and without UF were compared. In-vitro stimulation was tested on 10 ml of PB, at 37°C for 2 hours in Orbital Shaker SSL1 stirrer at flat speed. ECC stimulation was carried out on 100 ml of PB circulated 2 hours/37°C at a rate of 1.70 l/min.We tested Annexin V (marker of platelet activation) and CD41a (marker of platelet aggregation). Samples were analyzed on a flow cytometer. Results. We compared samples with UH and samples without (control=ctr) after in-vitro and ECC stimulation.We observed a greater positivity to Annexin V after ECC compared to in-vitro (25.9 vs 8.7%; p<0.01) in ctr samples. Similarly, CD41a+ was greater after ECC than in-vitro stimulation (68 vs 28.3%; p<0.01).In samples with UH, Annexin V was greater after ECC than in-vitro stimulation (25 vs 9%; p<0.001). A similar result was observed for CD41a (66 vs 23%; p<0.01). ECC induced a platelet activation compared to in-vitro stimulation. Addition of UH led to a reduction of platelet activation in vitro, and to a more marked reduction after ECC. Conclusions. ECC act on platelet activation.The addition of UH in the blood and in the circuit reduced activation, suggesting a positive action of the drug on the observed effects induced by biomaterials

    Atrial Remodeling in Pregnant Hypertensive Women: Comparison between Chronic and Gestational Hypertension

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    Objectives: Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is available on LA changes during pregnancy. The present study evaluated LA size and function in pregnant women with hypertension.Methods: Patients population included 30 women with chronic hypertension and 30 patients with gestational hypertension.A control group of 16 normotensive pregnant women was selected. Serial echocardiography was performed at 12 and 24 week of gestation in chronic hypertension and at 24 week in gestational hypertension and after delivery. LA diameters andvolumes were measured and compared. LA conduit volume, passive and active emptying volumes were calculated.Patients were divided in 2 groups according to max LAV Index &gt; 32 ml/m2 at 24 week of gestation.Results: Patients with chronic hypertension showed higher LA diameters (42 ± 2.0 vs. 36.5 ± 1.8; p&lt;0.001) and LA volumes (maximal volume 45.5 ± 4.0 vs. 38.1 ± 7.3; p&lt;0.001) compared with patients with gestational hypertension. The median value of max LAVI was 32 + 6.2 ml/m2 in chronic and 26 + 5 ml/m2 in gestational hypertension (p&lt;0.01). During follow-up patients with max LAVI &gt; 32 ml/m2 had more clinical complications evaluated as increase of therapy, fluid retention that need diuretic and hospitalization.Conclusion: Patients with chronic hypertension showed a more marked increased of LA volumes compared to gestationalhypertension due to a remodeling of atrial shape as effect of chronic overload. Patients with more dilated LA volumes developed a greater number of clinical complications suggesting that a dilated LA could be a parameter of hemodynamic instability
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