1,721,139 research outputs found
Ring Expansion of Thiochroman-4-one and Isothiochroman-4-one with Ethyl Diazo(lithio)acetate to Tetrahydro-benzothiepin-*-oxoesters
No full textWhen thiochroman-4-one (1 ) and isothiochroman-4-one (3) were treated with ethyl diazo(lithio)acetate, ethyl
2,3-dihydro-4-hydroxy-1-benzothiepin-5-carboxylate (2) and ethyl 1,3-dihydro-4-hydroxy-2-benzothiepin-5-
carboxylate (4), respectively, were formed. An improved procedure for the two-step addition-ring expansion
sequence is described. The preparation of 2.3-dihydro-1 -benzothiepin-4(5H)-one (7) and of 1.3-dihydro-2-
benzothiepin-4(5H)-one (8) from the esters (2) and (4), respectively, is reported. Deoxygenation of (7) and (8)
to 2,3,4,5-tetrahydro-1 -benzothiepin (9) and 1,3,4,5-tetrahydro-2-benzothiepin (1 0) by Caglioti reduction is described
Farnesoid x receptor modulators
No full textThe present application provides a compound of formula I or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof
O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids
No full textO-Benzyl-(S)-serine is a new selector for chiral ligand-exchange chromatography which has proved to be effective in the analytical separation of some natural and unnatural underivatized amino acids with fair to good separation and resolution factors. Both chiral mobile phase (CMP) and hydrophobically coated chiral stationary phase (CSP) approaches were successfully employed. A not completely clarified mechanism of chiral recognition is discussed
(S)-Benzyl-O-Serine (S-BOS), a new chiral selector for ligand-exchange chromatography of amino acids.
No full textInterfacial Properties of Monofluorinated Bile Acids Deviate Markedly from the Natural Congeners: Studies with the Langmuir-Pockels Surface Balance’
No full textConformationally constrained amino acids: novel enantiodivergent synthesis of all four isomers of 2-(tetrahydrofuran-2'-yl)glicine
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