1,721,051 research outputs found
Acute respiratory distress due to Verteporfin infusion for photodynamic therapy
No full textMost observed adverse events after photodynamic therapy (PDT) are mild or moderate and transient.1 In our series of 230 consecutive patients (123 female, 107 male) who were treated in our clinic with PDT for macular choroidal neovascularization related to age-related macular degeneration (187 patients) and pathologic myopia (43 patients), we observed 1 case of a severe reaction to verteporfin. A 50-year-old woman with a history of food allergy was referred to us for treatment with PDT of a myopic choroidal neovascular membrane. Eight minutes after intravenous verteporfin infusion, the patient reported a feeling of warmness departing from her neck and extending to the ears. In addition, the patient experienced a throbbing sensation in her throat, causing her to cough for about 1 minute without discharge. The infusion of verteporfin was immediately stopped. The patient's face appeared red and sweaty while she was trying to swallow and breathe with energy
Intravitreal bevacizumab as a treatment for choroidal neovascularisation secondary to myopia: 4-year study results.
No full textOBJECTIVES:
To report long-term follow-up results from intravitreal bevacizumab (IVB) treatment of choroidal neovascularisation (CNV) secondary to pathologic myopia (PM).
DESIGN:
The study was designed as a retrospective analysis of consecutive patients presenting with PM.
PARTICIPANTS:
Twenty-one eyes were examined from 20 different patients.
METHODS:
The study was designed as a retrospective, consecutive, nonrandomised, interventional case series. Twenty-one eyes from 20 patients with CNV secondary to PM who were treated with bevacizumab were followed for a maximum of 52 months. Best-corrected visual acuity (BCVA), optical coherence tomography, and fluorescein and indocyanine green angiography were performed on each patient at baseline presentation and every 3 months thereafter for the entire follow-up period. The continuation therapy was based on dosing as needed regimen (PRN) for treatment assessment.
RESULTS:
Overall, 15 (71.4%) of the 21 eyes studied demonstrated an improvement of ≥ 1 line on the Snellen chart. A total of 3 (14.3%) eyes showed no change with this analysis, and 3 (14.3%) eyes lost 1 line of discrimination. After the 4-year study period, fluorescein angiography suggested absence of angiographic leakage or fibrotic lesions in 15 eyes, and 3 eyes showed partial regression of myopic CNV. The remaining 3 eyes demonstrated total regression of CNV.
CONCLUSIONS:
Intravitreal bevacizumab appears to be an effective therapy for myopic CNV and its benefit may persist in a long-term follow-up, on the basis of PRN treatment compared to the natural history of the disease
Infrared imaging of choroidal involvement in Leber's idiopathic stellate neuroretinitis
No full textPURPOSE:
Leber's idiopathic stellate neuroretinitis (LIN) is a rare condition that has been always considered an inflammatory disease, with emphasis given to the optic disc and neuroretina alterations.
METHODS:
A healthy 54-year-old woman presented a sudden loss of vision in the left eye, referring to periocular pain, headache, and mild fever for 1 month. Tests of best-corrected visual acuity, optical coherence tomography, infrared (IR) filter, fluorescein, and indocyanine green angiography were performed at the follow-up.
RESULTS:
The patient submitted to IR imaging, which revealed diffuse patchy choroidal infiltrates involving the posterior pole midperiphery, which were still present after 3 years of follow-up.
CONCLUSION:
In this observation, we reported that choroidal involvement may occur in LIN. The IR filter is an important and noninvasive tool able to distinguish and follow choroidal infiltrates to better delineate the pathological process and elucidate the nature of the diseas
Photodynamic therapy of corneal neovascularization with verteporfin
No full textPurpose. To describe the effect of photodynamic therapy (PDT) using verteporfin (Visudyne((R))) on corneal neovascularization (CNV) in two patients. Methods. Two patients with corneal neovascularization were treated with a nonthermal laser light at 689 nm delivered 15 min after an intravenous infusion of verteporfin. Postoperative outcome of neovascularization was followed clinically (inflammation, intraocular pressure, and visual acuity) and photographically [color photographs and corneal fluorescein and indocyanine green (ICG) angiography] for a minimum of 6 months. Results. Successful photothrombosis of corneal neovascularization was obtained immediately after treatment in the two patients, and regression was verified by corneal fluorescein and ICG angiography. In one case, partial vessel recanalization was observed after 1 month, and treatment was repeated, with complete regression of new vessels. No relevant side effects were observed in our cases. Conclusions. PDT with verteporfin is an effective and safe procedure indicated for patients with corneal neovascularization; however, multiple sessions may be required
Endothelial cell density change in fully dislocated XEN Gel IMPLANT after trabeculectomy: A case report
No full textTo report a case of fully dislocated XEN Gel Implant device into the anterior chamber, 18 months after its implantation and its impact on endothelial cell density
Comparison between a fundus camera and scanning laser ophthalmoscope in acquiring fluorescence emission in vitro.
No full textChoroidal neovascularization in sorsby fundus dystrophy treated with photodynamic therapy and intravitreal triamcinolone acetonide
No full textUnfavorable effect of photodynamic therapy in a multiple detachment of pigment epithelium complicated by choroidal neovascularization
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