1,721,178 research outputs found
Geoinformatic methodologies and quantitative tools for detecting hotspots and for multicriteria ranking and prioritization: application on biodiversity monitoring and conservation
Full text linkChi ha la responsabilità di gestire un’area protetta non solo deve essere consapevole dei problemi ambientali dell’area ma dovrebbe anche avere a disposizione dati aggiornati e appropriati strumenti metodologici per esaminare accuratamente ogni singolo problema. In effetti, il decisore ambientale deve organizzare in anticipo le fasi necessarie a fronteggiare le prevedibili variazioni che subirà la pressione antropica sulle aree protette.
L’obiettivo principale della Tesi è di natura metodologica e riguarda il confronto tra differenti metodi statistici multivariati utili per l’individuazione di punti critici nello spazio e per l’ordinamento degli “oggetti ambientali” di studio e quindi per l’individuazione delle priorità di intervento ambientale.
L’obiettivo ambientale generale è la conservazione del patrimonio di biodiversità. L’individuazione, tramite strumenti statistici multivariati, degli habitat aventi priorità ecologica è solamente il primo fondamentale passo per raggiungere tale obiettivo. L’informazione ecologica, integrata nel contesto antropico, è un successivo essenziale passo per effettuare valutazioni ambientali e per pianificare correttamente le azioni volte alla conservazione.
Un’ampia serie di dati ed informazioni è stata necessaria per raggiungere questi obiettivi di gestione ambientale. I dati ecologici sono forniti dal Ministero dell’Ambiente Italiano e provengono al Progetto “Carta della Natura” del Paese. I dati demografici sono invece forniti dall’Istituto Italiano di Statistica (ISTAT). I dati si riferiscono a due aree geografiche italiane: la Val Baganza (Parma) e l’Oltrepò Pavese e Appennino Ligure-Emiliano.
L’analisi è stata condotta a due differenti livelli spaziali: ecologico-naturalistico (l’habitat) e amministrativo (il Comune). Corrispondentemente, i risultati più significativi ottenuti sono:
1. Livello habitat: il confronto tra due metodi di ordinamento e determinazione delle priorità, il metodo del Vettore Ideale e quello della Preminenza, tramite l’utilizzo di importanti metriche ecologiche come il Valore Ecologico (E.V.) e la Sensibilità Ecologica (E.S.), fornisce dei risultati non direttamente comparabili. Il Vettore Ideale, non essendo un procedimento basato sulla ranghizzazione dei valori originali, sembra essere preferibile nel caso di paesaggi molto eterogenei in senso spaziale. Invece, il metodo della Preminenza probabilmente è da preferire in paesaggi ecologici aventi un basso grado di eterogeneità intesa nel senso di differenze non troppo grandi nel E.V. ed E.S. degli habitat.
2. Livello comunale: Al fine di prendere delle decisioni gestionali ed essendo gli habitat solo delle suddivisioni naturalistiche di un dato territorio, è necessario spostare l’attenzione sulle corrispondenti unità amministrative territoriali (i Comuni). Da questo punto di vista, l’introduzione della demografia risulta essere un elemento centrale oltre che di novità nelle analisi ecologico-ambientali. In effetti, l’analisi demografica rende il risultato di cui al punto 1 molto più realistico introducendo altre dimensioni (la pressione antropica attuale e le sue tendenze) che permettono l’individuazione di aree ecologicamente fragili. Inoltre, tale approccio individua chiaramente le responsabilità ambientali di ogni singolo ente territoriale nei riguardi della difesa della biodiversità. In effetti un ordinamento dei Comuni sulla base delle caratteristiche ambientali e demografiche, chiarisce le responsabilità gestionali di ognuno di essi.
Un’applicazione concreta di questa necessaria quanto utile integrazione di dati ecologici e demografici viene discussa progettando una Rete Ecologica (E.N.). La Rete cosi ottenuta infatti presenta come elemento di novità il fatto di non essere “statica” bensì “dinamica” nel senso che la sua pianificazione tiene in considerazione il trend di pressione antropica al fine di individuare i probabili punti di futura fragilità e quindi di più critica gestione.Who has the responsibility to manage a conservation zone, not only must be aware of environmental problems but should have at his disposal updated databases and appropriate methodological instruments to examine carefully each individual case. In effect he has to arrange, in advance, the necessary steps to withstand the foreseeable variations in the trends of human pressure on conservation zones.
The essential objective of this Thesis is methodological that is to compare different multivariate statistical methods useful for environmental hotspot detection and for environmental prioritization and ranking.
The general environmental goal is the conservation of the biodiversity patrimony. The individuation, through multidimensional statistical tools, of habitats having top ecological priority, is only the first basic step to accomplish this aim. Ecological information integrated in the human context is an essential further step to make environmental evaluations and to plan correct conservation actions.
A wide series of data and information has been necessary to accomplish environmental management tasks. Ecological data are provided by the Italian Ministry of the Environment and they refer to the Map of Italian Nature Project database. The demographic data derives from the Italian Institute of Statistics (ISTAT). The data utilized regards two Italian areas: Baganza Valley and Oltrepò Pavese and Ligurian-Emilian Apennine.
The analysis has been carried out at two different spatial/scale levels: ecological-naturalistic (habitat level) and administrative (Commune level). Correspondingly, the main obtained results are:
1. Habitat level: comparing two ranking and prioritization methods, Ideal Vector and Salience, through important ecological metrics like Ecological Value (E.V.) and Ecological Sensitivity (E.S.), gives results not directly comparable. Being not based on a ranking process, Ideal Vector method seems to be used preferentially in landscapes characterized by high spatial heterogeneity. On the contrary, Salience method is probably to be preferred in ecological landscapes characterized by a low degree of heterogeneity in terms of not large differences concerning habitat E.V. and E.S..
2. Commune level: Being habitat only a naturalistic partition of a given territory, it is necessary, for management decisions, to move towards the corresponding administrative units (Communes). From this point of view, the introduction of demography is an essential element of novelty in environmental analysis. In effect, demographic analysis makes the goal at point 1 more realistic introducing other dimensions (actual human pressure and its trend) which allows the individuation of environmentally fragile areas. Furthermore this approach individuates clearly the environmental responsibility of each administrative body for what concerns the biodiversity conservation. In effect communes’ ranking, according to environmental/demographic features, clarify the responsibilities of each administrative body.
A concrete application of this necessary and useful integration of ecological and demographic data has been developed in designing an Ecological Network (E.N.).The obtained E.N. has the novelty to be not “static” but “dynamic” that is the network planning take into account the demographic pressure trends in the individuation of the probable future fragile points
Cavalcanti (Elena) éd Studi sull'episcopato Pecci a Perugia (1846- 1878)
No full textDurand Jean-Dominique. Cavalcanti (Elena) éd Studi sull'episcopato Pecci a Perugia (1846- 1878). In: Archives de sciences sociales des religions, n°64/2, 1987. pp. 251-252
Inherited thrombocytopenias: an updated guide for clinicians
No full textThe great advances in the knowledge of inherited thrombocytopenias (ITs) made since the turn of the century have significantly changed our view of these conditions. To date, ITs encompass 45 disorders with different degrees of complexity of the clinical picture and very wide variability in the prognosis. They include forms characterized by thrombocytopenia alone, forms that present with other congenital defects, and conditions that predispose to acquire additional diseases over the course of life. In this review, we recapitulate the clinical features of ITs with emphasis on the forms predisposing to additional diseases. We then discuss the key issues for a rational approach to the diagnosis of ITs in clinical practice. Finally, we aim to provide an updated and comprehensive guide to the treatment of ITs, including the management of hemostatic challenges, the treatment of severe forms, and the approach to the manifestations that add to thrombocytopenia
Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias
No full textMYH9-related disease (MYH9-RD) is one of the most frequent forms of inherited thrombocytopenia. It is transmitted in an autosomal dominant fashion and derives from mutations of MYH9, the gene for the heavy chain of non-muscle myosin IIA. Patients present with congenital macrothrombocytopenia with mild bleeding tendency and may develop kidney dysfunction, deafness and cataracts later in life. The term MYH9-RD encompasses four autosomal-dominant thrombocytopenias that were previously described as distinct disorders, namely May-Hegglin Anomaly, Sebastian, Fechtner and Epstein syndromes. Thrombocytopenia is usually mild and derives from complex defects of megakaryocyte maturation and platelet formation. It is easily diagnosed, in that the presence of giant platelets in peripheral blood raises the suspicion of MYH9-RD and a simple immunofluorescence test on blood films confirms the diagnostic hypothesis. However, genotype/phenotype correlations have been recognized and mutation screening is therefore required to define the risk of acquiring extra-haematological defects. Results of a small clinical study suggested that a non-peptide thrombopoietin mimetic might greatly benefit both thrombocytopenia and bleeding tendency of MYH9-RD patients
Thrombopoietin receptor agonists in hereditary thrombocytopenias
No full textHereditary thrombocytopenias (HTPs) constitute a heterogeneous group of diseases characterized by a reduction in platelet count and a potential bleeding risk. As a result of advances in diagnostic methods, HTPs are increasingly being identified, and appear to be less rare than previously thought. Most HTPs do not have effective treatments, except for platelet transfusion when bleeding occurs and in preparation for procedures associated with a risk of bleeding. Preliminary clinical evidence suggests that thrombopoietin receptor agonists (TPO-RAs) with an established use in the treatment of certain acquired thrombocytopenias are well tolerated and provide clinical benefits in patients with some forms of HTP. These drugs may therefore be considered for the treatment of HTPs in clinical practice. However, caution and close monitoring are recommended, owing to the absence of long-term safety data and the potential risks posed by prolonged bone marrow stimulation in certain HTPs. In this review, we summarize the available clinical data on TPO-RAs in the treatment of HTPs, and discuss their use in patients with these disorders. We believe that TPO-RAs will play a major role in the treatment of HTPs, particularly myosin heavy chain 9-related disease, Wiskott-Aldrich syndrome, X-linked thrombocytopenia, and thrombocytopenia caused by THPO mutations
When there was no GIS system: rediscovering archaeological researches of the 19th century through the use of the drone. The case study of Mount Siri (Anzi, Basilicata)
Full text linkModern archaeologists often find it difficult to identify the exact position on the field (and on the maps) of the finds brought to light during archaeological excavations, particularly those conducted before the second half of the 20th century. In these cases, in fact, they are obliged to record data and information on their GIS as being unable to locate the correct place, or even the area, of those ancient archaeological investigations. This inability to be precise creates several problems from a topographical point of view and negatively influences the archaeological reconstruction of specific territories or sites. Therefore, how is it possible to correctly locate and, as a result, mark on the map what was discovered or excavated in the recent past? One possible solution is the 3D reconstruction of a modern landscape through the use of the UAV technology and some derived applications, such as digital techniques based on Structure from Motion and Imaged-Based methodologies. The 3D model can be analyzed using the GIS system, and through the analysis of the micro-relief and aerial photos it is possible to use an important tool to locate past archaeological investigations. In this paper, we present the case study of Mount Siri (Anzi, Basilicata), the location of several important archaeological discoveries which were made during the 19th century
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