1,721,499 research outputs found
Unbounding STS - Science, technology and social order
No full textResearcher website on Pavone, Vincenzo. Consulted on 07/05/2019.I am a tenured researcher at the Institute of Public Policies of the Spanish National Research Council (CSIC) since 2006. I am member of the SPRI group on science, technology and innovation. Over the past ten years, I have developed a research line in critical science and technology studies, with a special focus on the political economy of reproductive and regenerative medicine, agro-biotechnology and synthetic biology, as well as surveillance-oriented security technologies. Always working on the complex relationship between science, technology and political economy, with a special focus on neoliberalism, I have recently opened a new research line on the relationship between society, neoliberalism and the global bioeconomy.Peer reviewe
New cyclic peptides, their preparation and pharmaceutical use as immunosuppressants
No full textCylic peptides cyclo[X1-X2-X3-X4-X5-X6] and cyclo[Y6-Y5-Y4-Y3-Y2-Y1] [X1, X2 = independently hydrophobic natural orsynthetic L-amino acid; X3, X5 = independently hydrophilic natural or synthetic L-amino acid or Gly; X4, Y4 = independently natural or synthetic D-amino acid or Gly, or a-methylalanine, a-aminocyclobutanecarboxylic acid, etc.; X6, Y6 = independently natural or synthetic L-amino acid or Gly, or a-methylalanine, a-aminocyclobutanecarboxylic acid, etc.; Y1, Y2 = independently hydrophobic natural or synthetic D-amino acid; Y3, Y5 = independently hydrophilic natural
or synthetic D-amino acid or Gly] were prepared as immunosuppressants useful for treating pathologies involving activation of T-lymphocytes. Their immunosuppressant activity was detd. in vitro and in vivo in human or murine mixed lymphocyte cultures by measuring lymphocyte proliferation by [3H]-TdR incorporation assay and the production of interferon g and
interleukin-5 by ELISA assay. Thus, cyclo[(b-1-Nal)-(b-1-Nal)-Glu-(D-Pro)-His-Asn] (b-1-Nal = b-1-naphthylalanine),
prepared by a solid phase synthesis, significantly decreased lymphocyte proliferation and inhibited prodn. of interferon g
and interleukin-5
RANTES-derived peptides with anti-HIV activity
No full textPeptides are provided which have 12-30 amino acids with a sequence homologous or corresponding to the sequence 10-34 of RANTES and have inhibitory activity against the human immunodeficiency virus (HIV) as well as anti-allergic and anti-inflammatory activity
PREPARATION OF ALL THE 4 DIASTEREOMERS OF BETA-PHENYLCYSTEINE METHYL-ESTER THROUGH CHROMATOGRAPHIC OPTICAL RESOLUTION OF THE 2,2-DIMETHYLTHIAZOLIDINE DERIVATIVES
No full textRantes-derived peptides for treatment of diseases involving RANTES receptors
No full textThis invention describes the preparation of RANTES-derived peptides of general formula Ac-C-x1-PYI-x2-x3-Y-NH2 (x1, x3 = Phe, Tyr, Nal, Cha; x2 = spacer of 2 to 12 amino acidic residues) for treatment of diseases in which RANTES receptor is involved. Peptides of the invention are useful for prevention or treatment of AIDS and other viral diseases, inflammatory, allergic, degenerative, and neoplastic diseases and all diseases in which chemokines or their receptors are involved
Synthetic heme-proteins in biosensors development
No full textThe presented work exploits the use of two different class of Mimochromes, the penta-coordinated Fe(III)-Mimochrome VI and the esa-coordinated Fe(III)-Mimochrome IV Lys3, in biosensor technology. These two artificial molecules were used as bio-recognition elements/signal transducers for biosensing. The aim of this thesis was to develop and optimise catalytic and affinity-based biosensors for the rapid screening of target analytes in complex matrices
La sostenibilità: la ricerca nell'area scientifico-naturalistica e tecnologica. Sostenibilità. Scienza e tecnologia nella tutela dell'ambiente
No full textL'alimentazione: la ricerca nell'area scientifico-naturalistica e tecnologica. Alimentazione. Il ruolo della scienza e della tecnologia
No full textMETALLOPROTEIN MODELS: DEVELOPING CATALYTIC SYSTEMS
No full textThis thesis reports the last achievements in protein design of di-iron-oxo-proteins with desired catalytic activity; it also reports design, synthesis and characterization of a new class of peptide-based heme-models, named MPs (Mini- Peroxidases), as well as preliminary catalytic activity studies
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