75 research outputs found
Review of Lyme Borreliosis in Africa—An Emerging Threat in Africa
No full textLyme borreliosis (LB) is more common in the Northern Hemisphere. It is endemic mainly in North America, where the vectors are Ixodes scapularis and Ixodes pacificus, and in Eurasia, where the vectors are Ixodes ricinus and Ixodes persulcatus. Both tick-borne diseases and LB are influenced by climate change. Africa and South America are crossed by the equator and are situated in both the Northern and Southern Hemispheres. In Africa, the LB is present on the Mediterranean and the Indian Ocean coasts. Borrelia lusitaniae is prevalent in countries bordering the Mediterranean Sea, such as Tunisia, Morocco, Algeria, and Egypt. Ticks were detected in the Ixodes Ricinus, which are carried by migratory birds and the Ixodes inopinatus and captured by the Psammodromus algirus lizards. The Borreliae Lyme Group (LG) and, in particular, Borrelia garinii, have been reported in countries bordering the Indian Ocean, such as Kenya, Tanzania, and Mozambique, transported by migratory birds from North African countries, where the vector was identified as Hyalomma rufipes ticks. This review aims to document the presence of Borreliae LG and LB in Africa
Kant and the problem of self-knowledge
No full textThis book addresses the problem of self-knowledge in Kant's philosophy. As Kant writes in his major works of the critical period, it is due to the simple and empty representation 'I think' that the subject's capacity for self-consciousness enables the subject to represent its own mental dimension. This book articulates Kant' s theory of self-knowledge on the basis of the following three philosophical problems: (1) a semantic problem regarding the type of reference of the representation 'I'; (2) an epistemic problem regarding the type of knowledge relative to the thinking subject produced by the representation 'I think'; and (3) a strictly metaphysical problem regarding the features assigned to the thinking subject's nature. The author connects the relevant scholarly literature on Kant with contemporary debates on the huge philosophical field of self-knowledge. He develops a formal reading according to which the unity of self-consciousness does not presuppose the identity of a real subject, but a formal identity based on the representation 'I think'
Kant and the problem of self-knowledge
No full textThis book addresses the problem of self-knowledge in Kant's philosophy. As Kant writes in his major works of the critical period, it is due to the simple and empty representation 'I think' that the subject's capacity for self-consciousness enables the subject to represent its own mental dimension. This book articulates Kant' s theory of self-knowledge on the basis of the following three philosophical problems: (1) a semantic problem regarding the type of reference of the representation 'I'; (2) an epistemic problem regarding the type of knowledge relative to the thinking subject produced by the representation 'I think'; and (3) a strictly metaphysical problem regarding the features assigned to the thinking subject's nature. The author connects the relevant scholarly literature on Kant with contemporary debates on the huge philosophical field of self-knowledge. He develops a formal reading according to which the unity of self-consciousness does not presuppose the identity of a real subject, but a formal identity based on the representation 'I think'
Autochthonous borderline tuberculoid leprosy in a man from Florida
No full textLeprosy (Hansen's disease) is a chronic contagious granulomatous disease principally affecting the skin and peripheral nervous system, caused by Mycobacterium leprae. In this report, we present a case of autochthonous leprosy in a man from Florida as the first human case reported from this region. Authors believe dermatologists need to be aware of the possibility of autochthonous transmission of leprosy in the Eastern-Southern United States, and should consider leprosy in any patient with atypical skin lesions, even when a history of contact with armadillo is missing
Estimation of DNA Degradation in Archaeological Human Remains
No full textThe evaluation of the integrity and quantity of DNA extracted from archaeological human remains is a fundamental step before using the latest generation sequencing techniques in the study of evolutionary processes. Ancient DNA is highly fragmented and chemically modified; therefore, the present study aims to identify indices that can allow the identification of potentially amplifiable and sequenceable DNA samples, reducing failures and research costs. Ancient DNA was extracted from five human bone remains from the archaeological site of Amiternum L'Aquila, Italy dating back to the 9th-12th century and was compared with standard DNA fragmented by sonication. Given the different degradation kinetics of mitochondrial DNA compared to nuclear DNA, the mitochondrially encoded 12s RNA and 18s ribosomal RNA genes were taken into consideration; fragments of various sizes were amplified in qPCR and the size distribution was thoroughly investigated. DNA damage degree was evaluated by calculating damage frequency (& lambda;) and the ratio between the amount of the different fragments and that of the smallest fragment (Q). The results demonstrate that both indices were found to be suitable for identifying, among the samples tested, those less damaged and suitable for post-extraction analysis; mitochondrial DNA is more damaged than nuclear, in fact, amplicons up to 152 bp and 253 bp, respectively are obtained
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