1,721,562 research outputs found

    Prevention of erlotinib-induced folliculitis with doxycycline

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    Deplanque et al. (2016) reported their experience after doxycycline administration in the prevention of erlotinib-induced folliculitis in patients affected by non-small-cell lung cancer (NSCLC). The oral epidermal growth factor receptor (EGFR), tyrosine kinase inhibitor erlotinib, is a second-line monotherapy for advanced NSCLC in patients with disease progression after first-line platinum-based therapy, recently approved also as first-line treatment for patients with EGFR mutationpositive NSCLC. Erlotinib is generally well tolerated. The most common side effects include skin toxicity, such as rash (folliculitis or acneiform rash/papulopustular eruption), xerosis, paronychia, pruritus, hair growth, and ocular disorders. Cutaneous adverse events may prejudice patient compliance, leading to dose reduction, treatment delay, or withdrawal. The authors randomized patients into two group

    Visualization of hair bulbs through the scalp: A trichoscopic feature of erosive pustular dermatitis of the scalp

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    Erosive pustular dermatitis of the scalp (EPDS) typically affects elderly people with scarring alopecia. Videodermoscopy (VD) of the scalp has never been assessed in the diagnosis of EPDS. To evaluate the trichoscopy features of EPDS, we carried out a retrospective analysis of VD images obtained in the scalp of ten patients who affected by EPDS and were compared with those obtained from a series of thirty patients who affected by other type of scarring alopecia. The most specific VD feature was thus represented by evident hair bulb in the scarring scalp, observed in all patients

    Acquired hypertrichosis localized on a subsiding psoriatic plaque after plaster application

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    Postcast hypertrichosis is a common transient occurrence in orthopedic patients and generally resolves within a few months. Until now, two cases of localized hypertrichosis occurring on more than one pre-existing psoriatic lesions are reported in the literature. We describe the case of a patient who simultaneously developed a single psoriatic plaque and overlying localized hypertrichosis after plaster application. This concurrence is exceptional and may be explained by the expression of several growth factors and cytokines influencing both the hair cycle and the psoriatic inflammatory working
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