389 research outputs found
Proton Therapy at the Institut Curie – CPO: operation of an IBA C235 cyclotron looking forward scanning techniques
No full textSince 1991, more than 6100 patients (mainly eye and
head&neck tumours) were treated at the Institut Curie –
Centre de Protonthèrapie d’Orsay (IC – CPO) using
Single Scattering and Double Scattering (DS) proton
beam delivery technique. After 19 years of activity, a 200
MeV synchrocyclotron has been shut down and replaced
by a 230 MeV C235 IBA proton cyclotron. This delivers
beam to two passive fixed treatment rooms and to one
universal nozzle equipped gantry (DS, Uniform Scanning
– US, Pencil Beam Scanning – PBS). In the past two
years of operation more than 95.5% of the scheduled
patients (near 500/year) were treated without being
postponed. According to IBA recommendations, we have
realized preventive maintenance and we have improved
some diagnostic tools allowing us to reduce the number of
downtime events from 499 in 2011 to 351 in 2012 [1]. In
order to enhance cancer treatment capabilities we are now
involved in the transition towards scanning particle
therapy, requiring even more accurate quality assurance
protocols. We describe here the main cyclotron issues
looking forward the scanning technique, the main goal
being the progress of our reliability performances
From a Symptom-Based to a Person-Centered Approach in Treating Depressive Disorders in Adolescence: A Clinical Case Formulation Using the Psychodynamic Diagnostic Manual (PDM-2)’s Framework
No full textBackground: Depressive disorders in adolescence are among the most challenging clinical syndromes to diagnostically identify and treat in psychotherapy. The Psychodynamic Diagnostic Manual, Second Edition (PDM-2) proposes an integration between nomothetic knowledge and an idiographic understanding of adolescent patients suffering from depression to promote a person-centered approach. This single-case study was aimed at describing and discussing the clinical value of an accurate diagnostic assessment within the PDM-2 framework. Method: Albert, a 16-year-old adolescent with a DSM-5 diagnosis of major depressive disorder, was assessed using instruments from various perspectives: the Structured Clinical Interview for DSM-5; the Psychodynamic Chart-Adolescent of the PDM-2, and other clinician-report instruments; and the Shedler–Westen Assessment Procedure
for Adolescents and Defense Mechanisms Rating Scale Q-sort, coded by external observers. Results: Albert’s assessment revealed impairments in various mental capacities, especially in regulating self-esteem. He presented a borderline personality organization at a high level and an emerging narcissistic personality syndrome. Conclusions: The case discussion showed the importance of providing clinically meaningful assessments to plan for effective treatments in youth populations. Especially, it is necessary to understand the adolescent’s unique characteristics in terms of mental and personality functioning and consider the developmental trajectories and adaptation processes that characterize this specific developmental period
"Si tout sujet est portrait” : figurations du moi dans Le Monde désert de Jouve et La Mort difficile de Crevel
No full textThe analysis of two novels from the 1920s selected as emblematic cases – Le Monde désert by Jouve and La Mort difficile by Crevel – leads the author to point out the connections between the figuration of the subject in literature and the portrait in painting. Indeed, the survival of the portrait itself as a pictorial genre can be seen as a sign of its involvement in the enquiry of identity and subjectivity. This article describes the three main axes that organise subjectivity as a portrait: the fluctuation between stasis and movement, the relational dimension and the fictional one. The portrait becomes the ideal model of a subject conceived as the result of a creative process. Hence, painting is not to be considered a mere narrative theme but a key to the interpretation of the novels and a metaphor of the construction of the subject
Selenium determination in biological matrices
No full textIn this study, we discuss some relevant aspects concerning the determination of selenium in biological materials with special reference to fluorometry and hydride generation atomic absorption spectroscopy (HG-AAS) techniques. The two methods may be applied without modifications to the analysis of Se in a wide spectrum of specimen types, and we describe their reliability in serum and hair analyses. Thirty-six independent control serum samples, the concentrations of which were unknown to the analyst, were analyzed in duplicate using both techniques in the Italian External Quality Assessment Scheme (EQAS). Accuracy was assessed by comparing Se values with those previously assigned by the organizers of the scheme using graphite furnace atomic absorption spectrometry (GF-AAS), which is the most frequently used technique for selenium determination in serum among the participants in the Italian EQAS. The results confirmed that fluorometry has a higher degree of accuracy than HG-AAS: the mean differences between observed and expected values were 1.5 mu g/liter (95% confidence interval, -1.06 to 3.97) for fluorometry and -1.1 mu g/liter (95% confidence interval, -5.05 to 2.76) for Hg-AAS. We also report some results obtained for the determination of Se in hair. Since a critical step in hair preparation is the pretreatment for removal of external contamination, we compared six different washing procedures. In general, Se is pearly leached from hair, but the efficiency of removal differed with the substance used, ranging from 0 to 13% of the original content. A nonionic detergent like Triton X-100 offers the advantage of safe working conditions and a substantial reduction in costs compared with organic solvents. Lastly, in a consistent group (n = 131) of women, Se in hair was found to be strongly reduced by the use of dye (389.9 ng/g vs 498.7 ng/g, P < 0.001). We recommend recording information on cosmetic treatments when hair is collected to evaluate Se reference values in epidemiological studies
«Una strania fenice». Marco Santagata: gli studi, le opere
No full textIl libro raccoglie contributi sulla figura e le opere di Marco Santagata, italianista e scrittore. Ne sono autori Annalisa Andreoni, Gian Mario Anselmi, Gabriele Baldassari, Roberto Barbolini, Pietro G. Beltrami, Claudia Berra, Alberto Bertoni, Laura Bosio, Cristiana Brunelli, Alberto Casadei, Roberta Cella, Michele Feo, Francesco Ferretti, Gianfranco Fioravanti, Serena Fornasiero, Christian Genetelli, Klaus W. Hempfer, Giuseppe Indizio, Vincenzo Manca, Grazia Melli, Cristina Montagnani, Matteo Palumbo, Laura Paolino, Diego Quaglioni, Amedeo Quondam, Gerhard Regn, Laura Regnicoli, Francisco Rico, Raffaele Ruggiero, Gino Ruozzi, Salvatore Settis, Silvana Tamiozzo, Chiara Tognarelli, Paola Vecchi Galli, Tiziano Zanato. Chiude il volume la Bibliografia degli scritti di Marco Santagata.
Marco Santagata (Zocca, 28 aprile 1947 ‒ Pisa, 9 novembre 2020) è stato studioso di letteratura italiana e romanziere. A lungo docente all’Università di Pisa, è autore di studi fondamentali su Petrarca – culminati nel commento al Canzoniere (1996, 20042) –, su Dante, Boccaccio, la poesia del Quattrocento e Boiardo, e sulla tradizione lirica fino a Leopardi, Pascoli e d’Annunzio. A ciò ha affiancato una felice produzione narrativa: tra i suoi romanzi Il copista (2000), Il maestro dei santi pallidi (2002, Premio Campiello 2003), L'amore in sé (2006, Premio Stresa), Come donna innamorata (2015, finalista al Premio Strega). La sua poliedrica natura di intellettuale impegnato e curioso del mondo lo ha portato anche ad occuparsi attivamente di politica culturale e universitaria e di divulgazione.The book collects contributions on the figure and works of Marco Santagata, scholar of Italian literature and novelist. The authors are Annalisa Andreoni, Gian Mario Anselmi, Gabriele Baldassari, Roberto Barbolini, Pietro G. Beltrami, Claudia Berra, Alberto Bertoni, Laura Bosio, Cristiana Brunelli, Alberto Casadei, Roberta Cella, Michele Feo, Francesco Ferretti, Gianfranco Fioravanti, Serena Fornasiero, Christian Genetelli, Klaus W. Hempfer, Giuseppe Indizio, Vincenzo Manca, Grazia Melli, Cristina Montagnani, Matteo Palumbo, Laura Paolino, Diego Quaglioni, Amedeo Quondam, Gerhard Regn, Laura Regnicoli, Francisco Rico, Raffaele Ruggiero, Gino Ruozzi, Salvatore Settis, Silvana Tamiozzo, Chiara Tognarelli, Paola Vecchi Galli, Tiziano Zanato. The volume closes with the Bibliography of Marco Santagata's writings.
Marco Santagata (Zocca (Modena), 28 April 1947 ‒ Pisa, 9 November 2020) was a scholar of Italian literature and novelist. Long a professor at the University of Pisa, he is the author of fundamental studies on Petrarch - culminating in the commentary on the "Canzoniere" (1996, 20042) -, on Dante, Boccaccio, fifteenth-century poetry and Boiardo, and on the lyric tradition up to Leopardi, Pascoli and d'Annunzio. Alongside this he has a successful narrative production: among his novels "Il copista" (2000), "Il maestro dei santi pallidi" (2002, Campiello Prize 2003), "L'amore in sé" (2006, Stresa Prize), "Come donna innamorata" (2015, finalist for the Strega Prize). His multifaceted nature as a engaged intellectual has also led him to actively deal with cultural and university politics and dissemination
CORRIGENDUM to The mechanisms of acute interstitial nephritis in the era of immune checkpoint inhibitors in melanoma
No full textIn this article, the authors’ first names and surnames were incorrectly listed in the wrong order. The correct author list is: Marco Tucci, Anna Passarelli, Annalisa Todisco, Francesco Mannavola, Luigia Stefania Stucci, Stella D’Oronzo, Michele Rossini, Marco Taurisano, Loreto Gesualdo and Franco Silvestris
The Climate Show:Episode 27: Conceptualizing just transition litigation
No full textIn this episode, Assistant Professor Linnéa Nordlander speaks to Professor Annalisa Savaresi from the University of Eastern Finland about the phenomenon of just transition litigation. The episode focuses on the article ‘Conceptualizing just transition litigation’, published in Nature Sustainability, of which Professor Savaresi is the lead author and Linnéa Nordlander is among the co-authors
Storie postcoloniali
No full textan essay on the rewriting of history in the work of postcolonial author
THE ROLE OF THE FIRM IN FIGHTING POVERTY DURING THE PANDEMIC: THE ITALIAN SYNERGY OF BARILLA-CARITAS
No full textThe aim of this research is to study firms as a means of distribution, and not only of production, of wealth. In crisis and emergency situations, such as the one caused by the COVID-19 pandemic,
a particularly serious problem of growing and widespread poverty emerges. The author believes that
in these situations the ethical function of firms becomes central. This function can be carried out effectively not only through the efficient management of the firm, but also through ethical actions, as the
creation of alliances and synergies between businesses and the Church, which help the processes of
distribution of wealth in society, in general, and in the weaker social classes in particular
Ruling minorities within groups of companies and their problems: Proposals from the European literature, 1776-1976
No full textThe author aims to find the systematic causal links between majorities and
minorities, especially to demonstrate how, even as corporate governance systems change, the same links remained unchanged, at least starting from the
original forms of limited liability (colonial) companies. The main cause of the
oppression of minorities lies in the power of control, which instead of belonging
to the majority of share capital holders, is held by close minority shareholders.
For this purpose, the author presents a historical reconstruction of the problem
concerning the balance of powers between dominant minorities and disjoint
majorities within the groups of companies
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