1,721,086 research outputs found
Fabrication and characterization of carbon nanotubes based coatings for the repair of cartilage tissue
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Human osteoblast-like cells response to nanofunctionalized surfaces for tissue engineering.
No full textCells are sensitive both to the micro/nanotopographic and chemical features of their surrounding environment. The engineering of the surface properties of biomaterials is then critical to develop bioactive devices with which to elicit appropriate cellular responses. To this regard, the layer by layer (LBL) self assembly technique represents a simple and versatile method to modify surface properties by the deposition of ultrathin films with specific and predetermined properties. In this work biomimetic coatings containing fibronectin, an adhesive glycoprotein of the extracellular matrix, were assembled by means of the LBL technique, and tested for the growth of MG63 human osteoblast-like cells, in order to evaluate their potential for the treatment of materials employed in bone-tissue engineering. As a first step the assembly process was optimized by quartz crystal microbalance measurements and subsequently was repeated on nickel/titanium, silicon and glass samples. The results obtained from the investigation of cell response to the modified surfaces, put in evidence that the deposited nanostructured ultrathin films are effective in promoting cell proliferation. Our results show the high potential of the developed bioactive coatings for the engineering of biomimetic implants and for the optimization of their integration with the surrounding tissues
Development of nanostructured biosensors by means of the Layer by Layer Self-Assembly technique
No full textNanoengineered polymeric capsules as elements of unconventional computing systems
No full textNanoengineered polymeric capsules are smart objects with a shell of 4-20 nm thick and a core volume, that can be filled with the different substances. The capsules can be delivered to a desirable place and the encapsulated material release can be triggered by the variation of the environmental medium parameters or by the external action. In this paper, we present important steps of the capsule preparation and discuss how they can be used in the field of chemical and bio-chemical unconventional computer systems
Functionalized biocompatible polyelectrolyte multilayers for drug delivery: In situ investigation of mechanical properties by dissipative quartz crystal microbalance
No full textNanostructured polymeric capsules have been applied in different fields, and specifically are regarded as promising for smart drug delivery applications. The physical-chemical and mechanical properties, and thus the permeability of the polyelectrolyte multilayer shell, play an important role in efficient delivery. Quartz crystal microbalance working in liquid has been used for the characterization of the buildup process and of the viscoelastic properties of biocompatible multilayers and of their functionalization by S-layer proteins. Optical and scanning electron microscopy have been used for the morphological characterization of nanostructured capsules obtained at physiological conditions by the assembly of the characterized multilayers onto spherical cores and by their subsequent removal. The proposed functionalized biocompatible capsules can be regarded as promising candidates for smart drug delivery application
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