1,721,058 research outputs found
Chronic limping in childhood, what else other than juvenile idiopathic arthritis: a case series
Full text linkBackground: Limping is a common clinical symptom in childhood; different clinical conditions may lead to limping and the diagnosis of the underlying cause may often be a challenge for the pediatrician. Case presentation: We describe the clinical manifestations, radiological pictures and disease course of other causes of limping in childhood, through a case series of seven cases and a brief discussion of each disease. Conclusions: although trauma is the most common cause of acute limping, when there is no history of traumatic events and the limping has a chronic course, Juvenile Idiopathic Arthritis is usually the most likely clinical diagnosis. However, other some rare conditions should be taken into account if JIA is not confirmed or if it presents with atypical clinical picture
Piomiosite 2016: ancora una sfida per il pediatra
No full textPyomyositis is a subacute, deep bacterial infection of skeletal muscles. Originally described in tropical areas, mainly in malnourished and immunocompromised subjects (“tropical pyomyositis”), it has been subsequently reported with an increasing frequency also in temperate climates. Larger muscle groups located in the pelvic girdle and in the lower extremities (including the thigh, calf and gluteal muscles) are most commonly affected, but any muscle group can be involved. S. aureus is the most common causative agent, being responsible for up to 90% of tropical cases and up to 75% of cases in temperate areas. Local trauma as a predisposing factor is reported in up to 39% of cases. There are no specific laboratory tests for pyomyositis. MRI is the gold standard for the diagnosis.
Treatment of pyomyositis largely depends on the stage of the disease. Prompt intravenous antibiotic therapy targeted on Staphylococcus aureus is generally effective for early infections. Both antibiotic therapy and drainage are necessary in more advanced stages. The paper reports one of muscle gluteus maximus involvement, reviews the literature and describes the experience with pyomyositis at Institute for Maternal and Child Health IRCCS “Burlo Garofolo” (Trieste, Italy) over the past ten years
Cutaneous manifestations in mevalonate kinase deficient patients treated with canakinumab
No full textCanakinumab is a human monoclonal antibody anti-interleukin-1β, it is the only biologic drug approved to treat mevalonate kinase deficiency (MKD). Canakinumab injection can trigger several local cutaneous reactions, but also chronic-relapsing skin infections and other manifestations. We report three cases of unusual cutaneous manifestations in patients treated with canakinumab
Delayed reactivation of chronic infantile neurologic, cutaneous, articular syndrome (CINCA) in a patient with somatic mosaicism of CIAS1/NLRP3 gene after withdrawal of anti-IL-1 beta therapy
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Procedural sedation for intra-articular corticosteroid injections in juvenile idiopathic arthritis (JIA) should be a standard of care.
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