5,727 research outputs found
I Remember column in which author Eva LaPlante writes of her visits to sites a
No full textI Remember column in which author Eva LaPlante writes of her visits to sites associated with E. B. White and his book Charlotte\u27s Web
sj-pdf-1-pmj-10.1177_02692163231151733 – Supplemental material for Impact of compounded drugs on the caregivers’ burden of home therapy management in pediatric palliative care: A descriptive study
No full textSupplemental material, sj-pdf-1-pmj-10.1177_02692163231151733 for Impact of compounded drugs on the caregivers’ burden of home therapy management in pediatric palliative care: A descriptive study by Francesca Burlo, Davide Zanon, Eva Passone, Maristella Toniutti, Giuliano Ponis, Egidio Barbi, Valentina Taucar and Lucia De Zen in Palliative Medicine</p
Eva Murray, author of Well Out to Sea , has been a resident of Matinicus Island
No full textEva Murray, author of Well Out to Sea , has been a resident of Matinicus Island since she moved there to teach at the island\u27s one-room schoolhouse in 1987. She discusses the differences between writing from an island and writing about an island as well as her efforts to dispel some stereotypes and myths about Matinicus through her writing
Presentation and symptom interval in children with central nervous system tumors. A single-center experience
No full textPURPOSE:
The aim of this study is to describe the symptoms and signs of central nervous system (CNS) tumors in a pediatric population and to assess the time interval between the onset of the disease and the time of the diagnosis.
METHODS:
A retrospective observational study was conducted at our Oncology Pediatric Unit between January 2000 and November 2011. We included 75 children between 5 months and 16 years (mean age of 7.8 ± 4.7 years), with male to female ratio of 3:2. The tumor localization was supratentorial in 51% of cases, and the most frequent histological type was low-grade astrocytoma (48%).
RESULTS:
Presenting symptoms were headache (31%), vomiting (31%), seizures (21%), and behavioral change (11%). The most common symptoms at diagnosis were headache (51%), vomiting (51%), visual difficulties (37%), seizures (24%), and behavioral change (21%). By the time of diagnosis, neurologic examination was altered in 68% of our patients. Vomiting (44%) and behavioral change (44%) were the most frequent symptoms in children under 4 years of age, headache (61%) and vomiting (54%) in children older than 4 years. The median interval between symptoms' onset and diagnosis was 4 weeks (range 0 to 314 weeks). A longer symptom interval was associated with younger age, infratentorial localization and low-grade tumors. The differences in symptom intervals between the different age, location, and grade groups were not statistically significant. Survival probability was influenced by tumor grade but not by diagnostic delay or age of the child.
CONCLUSIONS:
Headache and vomiting are the earliest and commonest symptoms in children with brain tumors. Visual symptoms and signs and behavioral change are often present. Abnormalities in neurological examination are reported in most of the children. Intracranial hypertension symptoms suggest the need for a neurological clinical examination and an ophthalmological assessment
Risk Factors of Persistent Hydrocephalus in Children with Brain Tumor: A Retrospective Analysis
No full textOBJECT: Hydrocephalus is one of the main complications of brain tumors in children, being present in about 50% of cases at the time of the tumor diagnosis and persisting up to 10-40% of cases after surgical resection. This is a single-institution retrospective study on the variables that may predict the need for treatment of persistent hydrocephalus in pediatric patients presenting with a brain tumor.METHODS: Retrospective case note review of 43 newly diagnosed brain tumors in children referred between April 2012 and January 2018 to our regional pediatric neuro-oncology service was carried out. Diagnosis of hydrocephalus was carried out using both preoperative and postoperative MRI to determine Evans' index (EI) and the fronto-occipital horn ratio (FOHR) from each scan. Simple logistic regression was used to analyze categorical variables as appropriate. A p value 0.34 (p = 0.028) and an FOHR >0.46 (p = 0.05) before surgery were associated with a higher prevalence of persistent hydrocephalus and therefore to the need for a cerebrospinal fluid drain device in the postoperative phase.CONCLUSION: Preoperative identification of children at risk for developing persistent hydrocephalus would avoid delays in planning the permanent cerebrospinal fluid drain devices. This study finds that an EI >0.34 and an FOHR >0.46 at diagnosis could impact on the therapeutic management of children with hydrocephalus associated with brain tumors. Prospective and larger-scale studies are needed to standardize this approach
Infective Uvulitis in a Child
No full textInfective uvulitis is a rare condition in children. In this report, we describe the case of a 4-year old-patient who presented a group A Streptococcus pharyngitis with uvulitis. No signs of epiglottitis were detected at nasal fibroscopy. She recovered rapidly with intravenous antibiotic therapy and 2 days of corticosteroid. Uvulitis is usually caused by group A Streptococcus or Haemophilus influentiae, but also other bacteria can be detected. Uvulitis can be isolated, or it can occur with epiglottitis and become an emergency
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