1,721,196 research outputs found
TRANS2CARE. Working plans: consciousness and perspectives
No full textThe project started on 1st April 2011 and will end on 30th September 2014.
The project received a budget of € 2,611,118 from the Italy-Slovenia 2007-2013
Cross-border Cooperation Programme.
Seven universities and research institutions, five hospitals and a center for technology
transfer distributed over the Programme area constitute the “Interregional network
for innovation and technology transfer for health improvement”, which will
continuously develop new protocols and biotechnological devices for the prevention,
early diagnosis and treatment of neurodegenerative, cardiovascular, orthopaedic and
oncological diseases
Entry of the University of Trieste in the Cross-Border Cooperation Programme Italy-Slovenia 2007-2013
Full text linkThe CBC Programme Italy-Slovenia 2007-2013 and the University of Trieste:
correspondence between Programme’s objectives for the European territorial
cooperation and the institutional University missio
The Big Step from Research to Innovation 2007-2013. A social report and the legacy of the cross-border strategic project Trans2Care.
No full textThe social report of the Trans2Care project is ready, two years after the conclusion of its activities on 30th September 2014. Subsequently, the project has been included in the programme of 12 public events, promoted by Universities and by the offices of the European Commission and serving as a good example. With this project, we the Partners have created a network for scientific cooperation that has no borders, joining forces to improve the results of research, rendering them suitable for transfer to companies and to construct a cultural basis for future research and innovation projects. This was useful for the 14 researchers, hired with project funds for 3 years and for their subsequent employment in research and development at a local level. This report is not meant to be a point of arrival, but a framework for everyone facing the challenges of local social, economic and scientific development that, day by day, is becoming more pressing in its complexity and urgency. Now, however, we are not starting from scratch all over again. We would like to thank the Programme for Cross-Border Cooperation Italy-Slovenia 2007- 2013 for the continued support of our work
Why is bioavailability of anthocyanins so low?
No full textAnthocyanins are water-soluble plant pigments conferring blue to pink colour to plant
organs [1]. Nearly 600 different molecules have been identified so far, 97% of which occurs
as glycosylated compounds. Their aglycone moiety is a flavonoid named anthocyanidin. The
six most common anthocyanidins display various hydroxylation and methoxylation patterns.
The repertoire of anthocyanins is so large, because various types of glycosyl moieties are
bound to the aglycone core [1].
These pigments occur not only in petals, but also in fruits, vegetables and grains [2] and
thus are constituents of the human diet. Their intake is highly variable, depending on the
consumption of anthocyanin-rich food; data collected in the United States lead to estimate
that anthocyanin daily individual intake may span from 12.5 [3] to 650 mg [4].
Following ingestion, anthocyanins are detected intact in blood [5, 6] in a time lapse
considerably shorter than that observed with other dietary flavonoids [7]. However, the
anthocyanins concentrations in plasma barely exceed 10-7 M, which translates into less than
0.1% absorption, including anthocyanin metabolites [8]. These features are indicative of
various biochemical issues underlying the quite limited bioavailability of anthocyanins in
mammalian organisms
Morire di fame
Full text linkDall’agosto 1940, nel ghetto di Varsavia furono recluse fino a 500.000 persone, destinate alla morte di fame mediante un razionamento alimentare malvagio. Nel periodo febbraio-luglio 1942, alcuni medici ebrei, che soffrivano le stesse condizioni dei loro
pazienti, intrapresero uno studio clinico su 70 adulti e 40 bambini, ricoverati in due ospedali del ghetto. Questo studio fu straordinario per ampiezza e rigore metodologico. Pochi manoscritti, contrabbandati fuori dal ghetto prima delle deportazioni del 1942 e della sua distruzione nel 1943, furono salvati e poi pubblicati a Varsavia nel 1946 nell’opera intitolata Choroba Głodowa: Badania kliniczne nad głodem wykonane w getcie warszawskim
z roku 1942, a cura di Emil Apfelbaum, uno dei medici del ghetto, e pubblicato da American Joint Distribution Committee. L’opera testimonia, con grafici e immagini, l’atrocità della “Malattia da fame nel Ghetto di Varsavia”. Essa ha dato un contributo straordinario alla scienza della nutrizione umana
The enigma of flavonoids and bilitranslocase activity in the cardiovascular system
Full text linkNumerous epidemiologic studies showed an inverse correlation
between dietary flavonoid consumption and cardiovascular risk, but the exact
mechanisms are still largely unknown. Flavonoids exhibit hormetic properties,
where low concentrations activate adaptive cellular stress response pathways
and thus lead towards cytoprotection, whereas high concentrations are
cytotoxic. However, the limited bioavailability of dietary flavonoids doubts the
relevance of effective flavonoid intracellular concentrations to induce bioactivity
in endothelial cells. Therefore, translocation of flavonoids through the cell plasma
membrane must occur via specific transporter proteins. Hereby, we describe the
involvement of the membrane transporter bilitranslocase (TC #2.A.65.1.1) as
the key underlying molecular mechanism for membrane transport, which might
help resolve the enigma of flavonoids bioactivity
The sulfhydryl groups responsible for bilitranslocase transport activity respond to the interaction of the carrier with bilirubin and functional analogues
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