1,721,229 research outputs found

    Screening of allergic rhinitis

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    The author, in an attempt to define the most suitable means for the preclinical diagnosis of allergic rhinopathy, submitted 1620 pupils from seven different state schools to examination. Their parents were asked to fill in a questionnaire through which 370 were considered to be "at risk". All children underwent scratch skin tests: 73 with positive skin reactions also underwent nasal examination, measurement of immunoglobulins in nasal secretion, rhinomanometry, nasal exposition tests, determination of blocking antibodies and radiological examination of the paranasal sinuses. RAST was carried out in 30 cases. After the analysis of the clinical data, the author came to the conclusion that the tests of nasal conductance and provocation, of mucociliary clearance and determination of blocking antibodies are adequate means for the long term study of allergic rhinitis and for the follow-up of contingent hyposensitization therapy. As far as the preclinical diagnosis is concerned the skin tests and the radiological examination of the paranasal sinuses are to be considered more specific than RAST which, in the population sample taken into consideration, was positive exclusively in those cases that already had a manifest symptom complex

    Valutazione dell'efficacia di ambroxol compresse effervescenti nel trarramento delle affezioni catarrali delle vie areree superiori: studio controllato vs n-acetilcisteina. [Evaluation of efficacy of Ambroxol effervescent tabs in the treatment of catarrhal diseases of upper respiratory tract: Controlled study vs N-acetylcysteine]

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    In a group of 30 patients affected by catarrhal diseases of upper respiratory tract (rhinopharyngitis, rhino-otitis and rhinosinusitis) the authors evaluated the effects of a cycle of ten days of therapy with Ambroxol (120 mg/die) or N-Acetilcysteine (1200 mg/die) (both in effervescent composition) on symptoms patterns, on tympanometric pictures and nasal mucociliary transport time (tTMC). At the end of treatment with Ambroxol we noted a global improvement of clinical parameters, specifically nasal obstruction and nasal secretion data. Also tympanometric curves (37% of normalization) and nasal mucociliary transport time greatly improved. This last parameter shows a significant improvement (from 23.8 to 16.0 minutes) in the group of patients affected by rhinosinusitis. Likewise to an improvement of tTMC we assisted to a similar finding about rheological characteristic of nasal mucus that from thick turn into fluid. In spite (global efficacy of N-Acetylcysteine on symptoms, any drastic improvement of single parameters didn't happen. Particularly, the treatment with N-Acetylcysteine did not induce any improvement neither of the tympanometric pictures nor of the tTMC and nasal secretion features. Tolerability profile was excellent for both drugs. Basing on our findings we can consider that Ambroxol, effervescent tabs, is a valid treatment for common catharral diseases of upper respiratory trac
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