95 research outputs found
Some Contribuitions of the Neo-Deterministic Seismic Hazard Assessment Approach to Earthquake Risk Assessment for the City of Sofia
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Implementation of multicultural education at grammar schools in České Budějovice
No full text(česky) Název práce: Role sociálního pedagoga a asistenta pedagoga při integraci žáků (dětí) ze sociokulturně odlišného prostředí. Autor: Bc. Ivanka Gracíková Vedoucí práce: PaedDr. Eva Valášková Vincejová, Ph.D. Instituce: Univerzita Karlova, filozofická fakulta, katedra pedagogiky Počet slov: 18258 Tato diplomová práce je zaměřena na realizaci multikulturní výchovy na gymnáziích v Českých Budějovicích. Cílem práce je vymezit základní teoretická východiska multikulturní výchovy, její realizaci na vybraných gymnáziích v Českých Budějovicích a porovnání rozdílů realizace multikulturní výchovy mezi státním a soukromým zřízením daného typu gymnázia. Teoretická část pojednává o multikulturní výchově z hlediska etnického i z hlediska kulturních a jazykových menšin a zabývá se její specifikací v kurikulárních dokumentech. Praktická část se věnuje stanoveným cílům diplomové práce, dále zmiňuje použitou metodiku kvantitativního výzkumu a popisuje výzkumný soubor včetně uvedení výsledků získaných dat, které objasní stanovené cíle, a to zjistit znalosti a postoje studentů posledních ročníků gymnázií s problematikou multikultury/interkultury nejen u nás, ale i ve světě. Klíčová slova: Multikultura, vzdělávání, gymnázium, menšina, student, etnikum.(in English) Thesis title: Role of Social Educator and Teacher Assistant in Integration of Pupils (Children) from a socio-culturally different environment. Author: Bc. Ivanka Gracíková Academic supervisor: PaedDr. Eva Valášková Vincejová, Ph.D Institution: Charles University, Faculty of Arts, Department of Pedagogy Basic words count: 18258 This diploma thesis is focused on the implementation of multicultural education at grammar schools in České Budějovice. The aim of the thesis is to define the basic theoretical basis of multicultural education, its implementation at selected grammar schools in České Budějovice and to compare the differences in the implementation of multicultural education between state and private establishment of a given type of grammar school. The theoretical part deals with multicultural education from an ethnic and cultural point of view and linguistic minorities and deals with its specification in curricular documents. The practical part deals with the objectives of the thesis, mentions the methodology of quantitative research and describes the research file, including the results of the data, which clarifies the objectives, namely to find out the knowledge and attitudes of high school students with multicultural / intercultural issues not only in our country, but even in...Katedra pedagogikyDepartment of EducationFilozofická fakultaFaculty of Art
Generated Accelerograms on the Example of Sofia City for the Purposes of Microzonation
No full textExpected seismic excitation is analyzed along three profiles with length of 14 km, passing through the central part of Sofia city. Accelerograms are simulated for a scenario earthquakes with M=7. A hybrid modelling method is applied, based on the modal summation technique and finite differences scheme. The site amplification is calibrated taking into account the response spectra ratio of 2D to 1D models. As a result accelerograms are generated at intervals of 100 m along the three profiles. The seismic response of reinforced concrete industrial building designed according to the Eurocodes is studied by use of the generated accelerograms. Response characteristics, such as damage index and story drift are calculated. Maps of distribution of the damage index on the area covered by the three profiles are plotted for the considered scenario. The results could be used for the purpose of microzonation.JRC.DG.G.5 - European laboratory for structural assessmen
The BTC Price Prediction Paradox Through Methodological Pluralism
No full textBitcoin’s extreme price volatility presents significant challenges for investors and traders, necessitating accurate predictive models to guide decision-making in cryptocurrency markets. This study compares the performance of machine learning approaches for Bitcoin price prediction, specifically examining XGBoost gradient boosting, Long Short-Term Memory (LSTM), and GARCH-DL neural networks using comprehensive market data spanning December 2013 to May 2025. We employed extensive feature engineering incorporating technical indicators, applied multiple machine and deep learning models configurations including standalone and ensemble approaches, and utilized cross-validation techniques to assess model robustness. Based on the empirical results, the most significant practical implication is that traders and financial institutions should adopt a dual-model approach, deploying XGBoost for directional trading strategies and utilizing LSTM models for applications requiring precise magnitude predictions, due to their superior continuous forecasting performance. This research demonstrates that traditional technical indicators, particularly market capitalization and price extremes, remain highly predictive in algorithmic trading contexts, validating their continued integration into modern cryptocurrency prediction systems. For risk management applications, the attention-based LSTM’s superior risk-adjusted returns, combined with enhanced interpretability, make it particularly valuable for institutional portfolio optimization and regulatory compliance requirements. The findings suggest that ensemble methods offer balanced performance across multiple evaluation criteria, providing a robust foundation for production trading systems where consistent performance is more valuable than optimization for single metrics. These results enable practitioners to make evidence-based decisions about model selection based on their specific trading objectives, whether focused on directional accuracy for signal generation or precision of magnitude for risk assessment and portfolio management
D-dimer – laboratory aspects and clinical application
No full textD-димер е краен продукт на плазминовото разграждане на кръстосано-свързания фибрин и е маркер за активацията на коагулационната и фибринолитичната системи. В рутинната клинична практика се използва широко за изключване на венозен тромбоемболизъм (ВТЕ), за оценка на риска от рецидивиращи тромбози и определяне на оптималната продължителност на антикоагулантната терапия, за диагноза и мониториране на синдром на дисеминирана интравазална коагулация (ДИК). Аналитичните методи за измерване на D-димер се характеризират с висока чувствителност, но относително ниска специфичност, тъй като D-димер е повишен при редица физиологични и патологични състояния. Комбинацията от измерването на D-димер със скали за оценка на клиничната вероятност позволява безопасно отхвърляне на ВТЕ. С цел повишаване на диагностичната надеждност са предложени стратегии, които да повишат специфичността на D-димер. Прилагането на възрастово-коригиран и адаптиран към клиничната вероятност разграничителен праг за ВТЕ позволява отхвърляне на диагнозата при по-голям брой пациенти без да се налага извършване на допълнителни образни изследвания. D-dimer is a terminal product of plasmin-mediated degradation of cross-linked fibrin and is a marker for the activation of both the coagulation and fibrinolytic systems. D-dimer is widely used in routine clinical practice to rule out venous thromboembolism (VTE), assess the risk of recurrent thrombosis, and determine the optimal duration of anticoagulant therapy, as well as for the diagnosis and monitoring of disseminated intravascular coagulation (DIC). The analytical methods for measuring D-dimer are high sensitive but relatively low specific, as D-dimer levels are elevated in several physiological and pathological conditions. The combination of D-dimer measurements with clinical probability scores allows for the safe exclusion of VTE. To improve diagnostic accuracy, several strategies have been proposed to increase the specificity of D-dimer testing. The application of age-adjusted and clinical probability adapted cutoff values for VTE allows VTE exclusion in a greater number of patients without the need for additional imaging studies
Preliminary Results on October 27, 2004 Vrancea Earthquake - Case Study on Sofia Strong Ground
No full textThe intermediate-depth earthquakes in Vrancea (Romania) are particularly notable in the group of the European earthquakes. The scope of this work is to show preliminary results of the seismic effects of 27, October, 2004 earthquake from the Vrancea seismogenic zone. Particular attention is done on the records registered in Bucharest and Sofia. The study is limited to the question about the level of the ground motions in terms of recorded spectral amplitudes during 2004 Vrancea strong earthquakes. For this purpose we discuss: (1) the strong ground motion records in due to Vrancea strong earthquake, 2004; (2) the regional seismicity and a review of the available recurrence and attenuation relationships; (3) results from the response of one storey building due to scaled record in Sofia.
The results of this study confirm the significant influence of the Vrancea intermediate-depth seismogenic zone on very large territory of Bulgaria and the need to provide realistic seismic input, from Vrancea sources, for the purposes of seismic microzonation.JRC.G.5 - European laboratory for structural assessmen
Implementation of multicultural education at grammar schools in České Budějovice
No full text(in English) Thesis title: Role of Social Educator and Teacher Assistant in Integration of Pupils (Children) from a socio-culturally different environment. Author: Bc. Ivanka Gracíková Academic supervisor: PaedDr. Eva Valášková Vincejová, Ph.D Institution: Charles University, Faculty of Arts, Department of Pedagogy Basic words count: 18258 This diploma thesis is focused on the implementation of multicultural education at grammar schools in České Budějovice. The aim of the thesis is to define the basic theoretical basis of multicultural education, its implementation at selected grammar schools in České Budějovice and to compare the differences in the implementation of multicultural education between state and private establishment of a given type of grammar school. The theoretical part deals with multicultural education from an ethnic and cultural point of view and linguistic minorities and deals with its specification in curricular documents. The practical part deals with the objectives of the thesis, mentions the methodology of quantitative research and describes the research file, including the results of the data, which clarifies the objectives, namely to find out the knowledge and attitudes of high school students with multicultural / intercultural issues not only in our country, but even in..
Antiplatelet therapy – platelet function test for platelet response assessment
No full textДвойната антиагрегантна терапия е основен фармакологичен механизъм за потискане на тромбоцитната функция с цел предотвратяване на тромботичните усложнения след перкутанна коронарна ангиопластика. Настоящите проучвания показват, че използването на прецизирана антитромбоцитна терапия води до значимо клинично подобрение след имплантация на стент. Необходимостта от индивидуализиране на терапията се обуславя от наличието на широки интериндивидуални вариации в тромбоцитния отговор и от различната фармакодинамика на отделните P2Y12 инхибитори – клопидогрел, празугрел и тикагрелор. Оценката на ADP индуцираната тромбоцитната агрегация спомага за предотвратяване както на нежеланите исхемични събития, така и на асоциирания риск от кървене. Основната цел на нашите проучвания първоначално беше установяване и преодоляване на резистентността към терапията с клопидогрел с оглед намаляване на нежеланите исхемични събития. С прилагането на празугрела и тикагрелора – медикаментите с по-силен и предвидим антиагрегантен ефект, вниманието ни се насочи към установяване на увеличен отговор и кървене на фона на двойна антиагрегантна терапия и индивидуализирането ѝ, с цел минимизиране на кървенето. Дългогодишният ни опит показва, че импедансната агрегометрия е бърз и надежден метод за оценка на тромбоцитната функция. Тестовете дават възможност за диференциране на пациентите с оптимална, висока и ниска тромбоцитна реактивност към терапията с P2Y12 инхибитори. Основният извод от нашите проучвания – липсата на исхемични събития при индивидуализирането на терапията без увеличаване на хеморагичния риск, осигурява намирането на баланс между исхемичните и хеморагичните усложнения по време на терапия. Dual antiplatelet therapy is the main pharmacological mechanism used to suppress platelet function in order to prevent thrombotic complications following percutaneous coronary angioplasty. Current studies show that the use of tailored antiplatelet therapy leads to significant clinical improvement after stent implantation. The need to individualize therapy is due to the presence of wide interindividual variations in platelet response and the differing pharmacodynamics of various P2Y12 inhibitors – clopidogrel, prasugrel, and ticagrelor. Assessment of ADP-induced platelet aggregation helps prevent both adverse ischemic events and the associated bleeding risk. The primary objective of our studies was initially to establish and overcome resistance to clopidogrel therapy with the aim of reducing adverse ischemic events. With the introduction of prasugrel and ticagrelor – medications that offer a stronger and more predictable antiplatelet effect – our focus shifted to identifying increased response and bleeding in the context of dual antiplatelet therapy, and to individualizing therapy to minimize bleeding. Our long-term experience shows that impedance aggregometry is a fast and reliable method for evaluating platelet function. The tests allow for the differentiation of patients with optimal, high, and low platelet reactivity to P2Y12 inhibitor therapy. The main conclusion from our studies is that individualizing therapy leads to the absence of ischemic events without an increased risk of hemorrhage, thereby achieving a balance between ischemic and hemorrhagic complications during treatment
Implementation of the Domestic Violence Law in the Republika Srpska
No full textIn this paper author analyzes criminal offence "Violence in family or extended family". This criminal offence was introduced for the first time in the new Criminal Code of the Republika Srpska in 2000 (article 198). In the first part of the paper author exposes characteristics of legal provisions regarding criminal offence "Violence in family or extended family". In the second part practical implementation of this criminal offence is analyzed. For doing that analyzes, the author uses the interviews carried out with representatives of the police, prosecutors judges and representatives of non-governmental organizations. At the end author suggests introduction of certain measures for victim protection such as mandatory arrest of a perpetrator, the increased efficiency of the criminal procedure, restraining orders (regarding communication and contact between perpetrator and victim) and other measures, which should provide adequate implementation of this incrimination and optimal protection of victims of this crime
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