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Pneumologia. In: MARCELLO NEGRI. Medicina Pratica. vol. 2, p. 1037-1044, TORINO:UTET, ISBN: 9788802080536
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Pulmonary hypertension: A prognostic factor for response to non invasive mechanical ventilation in COPD exacerbations
No full textOur study is an observational, consequently not randomized, trial enrolling patients experienced a COPD exacerbation with respiratory failure and hypercapnia, subsequently treated with NIV. Evaluation of the role of PH, as comorbidity, in exerting influence for response to the NIV was a secondary endpoint of the study.our study confirms the role of PH in COPD with hypercapnic exacerbation as an unfavorable prognostic factor
to the NIV response
Inquinamento atmosferico da particolato ed effetti sull'apparato respiratorio.
No full textVengonodescritte le' correlazioni esistenti tra inquinamento atmosferico da particolato ambientale ed incrementodi morbilità e mortalità per cause respiratorie. Verranno esaminate le categorie a rischio, rappresentatedagli adulti con BPCO e dai bambini che soffrono di asma bronchiale. Viene analizzato il danno acutoed il deterioramento funzionale progressivo a carico dell'apparato respiratorio causati dal particolato. L'attenzionesarà focalizzata sul parti colato fine che è il principale responsabile di danno polmonare perstressossidativo ed infiammazione con riduzione della funzionalità respiratoria. Verranno successivamentedescritti i meccanismi attraverso i quali il particolato causa un danno polmonare: in particolare lostressossidativo che innesca cascate enzimatiche culminanti con l'attivazione di geni che svolgono un ruolodi primo piano nella risposta infiammatoria attraverso l'up-regulation di alcuni mediatori proinfiammatoricomecitochine e chemochine. Il processo si manifesta con una iperespressione dei meccanismi dell'infiammazioneper cui, nel paziente affetto da patologie croniche dell'apparato respiratorio si perpetua ilprocessoflogistico accentuando le modificazione anatomopatologiche ed il quadro clinico
To know for reporting. Asthmatic children in urban areas:short-term effect and long-term damage 3rd International Conference on Children’s Health and Environment
No full textCompressor/nebulizers differences in the nebulization of corticosteroids. The CODE study (Corticosteroids and Devices Efficiency)
No full textBackground. Nebulization is a common method of medical aerosol generation and it is largely used by adults and children all over the world, both for emergency treatment of acute illness and for long-term home treatment of lung diseases. The aim of this study was to determine the differences in nebulization of inhaled corticosterolds among four representative types of compressor/nebulizers. Methods: Twelve compressor/jet nebulizers from four commercial sources were studied (three for each type): Clenny (MEDEL), Turbo Boy/LC Plus (PARI), Nebula Nuovo/MB5 (MARKOS MEFAR) and Maxaer (ARTSANA) compressor/Sidestream (Medic-Aid Ltd.) nebulizer. We compared the required time for the treatment (nebulization time), output/minutes, compressor pressures, and aerosol characteristics of inhaled corticosteroids: Beclomethasone dipropionate, Flunisolide, Fluticasone propionate and Budesonide. Results: Nebulization Times showed a significant difference between nebulizer and inhaled corticosteroids for Clenny, Turbo Boy, and Maxaer. A considerable difference in the output of nebulized drugs was observed through the compressors/nebulizers. MMAD of all inhaled corticosteroids was significantly different among the four nebulizers. The percentage of particles 90%), whereas with flunisolide was good only for Clenny (98.8%) and Maxaer (96.3%), and with fluticasone only for Clenny (98%), Turbo Boy (99.1%), and Maxaer (86%). Also percentage of particles < 2 pm showed significant variability among the devices. Conclusions: Our results clearly demonstrate that compressor/nebulizer unit plays a key role in the effectiveness of the treatment during inhaled corticosteroid t herapy, and that several differences exist in the performance of the different nebulizers studied. Therefore, the device has the same importance of the compound to reach the best clinical response in the inflammatory diseases of the lower airways
Danno alla salute da inquinamento atmosferico urbano: il bambino asmatico è l’invalido di domani?
No full textTollerabilità e efficacia terapeutica della rifabutina nel trattamento della tubercolosi polmonare.
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