1,721,055 research outputs found
New biodegradable dextran-based hydrogels for protein delivery: Synthesis and characterization
No full textA new derivative of dextran grafted with polyethylene glycol methacrylate through a carbonate bond (DEX–PEG–MA) has been synthesized and characterized. The photo-crosslinking reaction of DEX–PEG–MA allowed the obtainment of biodegradable networks tested for their mechanical and release properties. The new hydrogels were compared with those made of dextran methacrylate (DEX–MA), often employed as drug delivery systems of small molecules. The inclusion of PEG as a spacer created additional interactions among the polymeric chains improving the extreme fragility and lack of hardness typical of gels made of DEX–MA. Moreover, the different behavior in terms of swelling and degradability of the networks was able to affectthe release of a model macromolecule over time, laking DEX–PEG–MA matrices suitable candidates for the delivery of high molecular weight peptides. Interestingly, the combination of the two dextran derivatives showed intermediate ability to modulate the release of high molecular weight macromolecules
Effects of processing on the organoleptic and nutritional properties of blueberry–derived products
No full textInfluence of fat extraction methods on the peroxide value in infant formulas
No full textFive methods for fat extraction from powdered milk infant formulas were tested for reproducibility and accuracy of the peroxide value determination. n-Hexane, n-hexane after mortar grinding in the presence of some water, n-hexane/methanol, dichloromethane/methanol/petroleum ether and n-hexane/isopropanol were used for the extraction. Among all the tested methods, n-hexane/isopropanol 3:1 mixture gave quantitative yields in fat extraction from reconstituted milk This method combined with the classic iodometric titration gave the best result in terms of reproducibility, detecting peroxide values down to 1.1 (n=5, RSD=10%) and 1.3 meq O-2/kg for 4 and 10 g of milk respectively. All these features, the rapidity, low cost, easiness, as well as the relatively low amount of sample employed for the analysis with no need of any special instrumentation, make it suitable as a routine method for the evaluation of the quality of such irreplaceable dietetic products as milk infant formulas are. (C) 2012 Elsevier Ltd. All rights reserved
Comparison between third derivative spectrophotometric method and hplc-dad method in detection of malondialdehyde in infant formulae, human and cow milks
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