1,720,980 research outputs found
IL PEPTIDE CORRELATO AL GENE DELLA CALCITONINA (CGRP): FISIOPATOLOGIA E CLINICA
No full textFISIOPATOLOGIA E CLINICA DEL PEPTIDE CORRELATO AL GENE DELLA CALCITONINA (CGRP
Evidence for circadian variability in the renin angiotensin II system
No full textCircadian variations of P.R.A. and angiotensin II were studied in three normal subjects and nine hypertensive patients. All data were analysed by a mathematical-statistical method called "cosinor". Analysis of results has shown: 1) Circadian rhythm of P.R.A. which in the normal subjects reaches its acrophase (maximum daily level) in the morning, while in the hypertensive patients the acrophase recurs in the afternoon; 2) Circadian rhythm of angiotensin II in the normal subjects, which is not detected in the hypertensive patients. Angiotensin I does not exhibit rhythm in both groups
Plasma aldosterone response to domperidone, an extracerebral dopamine receptor blocker, in normal subjects
No full textPlasma aldosterone response to domperidone, an extracerebral dopamine receptor blocker, in normal subject
Pentagastrin does not affect the renin-angiotensin-aldosterone system in man.
No full textThe manuscript describes the lack of effects of pentagastrin on the renin-angiotensin-aldosterone system in ma
Effect of ketanserin, an inhibitor of 5-HT2 receptors, on the aldosterone-stimulating action of metoclopramide
No full textTo estimate the possible involvement of a peripheral serotonergic pathway in the mechanism of the aldosterone-stimulating effect of metoclopramide (M) the plasma aldosterone (PA), renin activity (PRA) and prolactin (PRL) response to M was studied in 6 normal subjects before and after administration of ketanserin (K), a pure, specific, and selective blocking agent of 5-hydroxytryptamine type 2 (5-HT2) receptors. With K preadministration the M-induced increase of PRL was similar to that observed in control conditions, in accordance with the specific and peripheral antiserotonergic action of the drug. K potentiated the PA and PRA elevation in response to M. These data suggest that the PA response to M is not related to M's agonist activity at the peripheral 5-HT2 receptors level. The results further indicate that K can induce an enhancement of the activity of renin-angiotensin-aldosterone system with an higher PRA and PA response to stimulatory action of M
Stimulation of growth hormone and corticotropin release by angiotensin II in man.
No full textThe intravenous (IV) infusion of angiotensin II (AII) was administered to seven healthy male volunteers in a randomized placebo-controlled study. As expected, AII induced a significant increase in blood pressure and plasma aldosterone concentrations. AII caused a significant increase in corticotropin (ACTH) and growth hormone (GH) release, but had no effect on the release of thyrotropin (TSH) and prolactin (PRL). These findings suggest that peripherally circulating AII might influence ACTH and GH secretion in human
ENDOCRINE AND GASTROINTESTINAL EFFECTS OF NEUROTENSIN
No full textENDOCRINE AND GASTROINTESTINAL EFFECTS OF NEUROTENSI
DELTA-OPIOID RECEPTOR MODULATION OF THE HYPOTHALAMIC -PITUITARY-ADRENOCORTICAL AXIS
No full textSTUDY ON THE MODULATION OPERATED BY DELTA-OPIOID RECEPTOR ON THE HYPOTHALAMIC -PITUITARY-ADRENOCORTICAL AXI
Stimulatory effect of angiotensin II upon luteinizing hormone release normal women.
No full textIn this study we investigated the effect of intravenous infusion of angiotensin II (AII) on plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in fertile healthy women examined both in the middle follicular phase (MFP) and in the middle luteal phase (MLP). As expected, AII induced a significant increase in blood pressure and plasma aldosterone concentration. In MFP, plasma FSH and LH levels did not show any significant change after AII infusion, if compared to both saline and preinfusion basal values. In MLP, AII significantly increased plasma LH (p less than 0.02 vs. baseline values and p less than 0.01 vs. placebo values), but not plasma FSH. The area under the curve during AII infusion resulted significantly higher than during placebo infusion (p less than 0.001). Therefore, these data demonstrate that peripherally injected AII at pressive dose produces an increase in plasma LH levels in normal women on luteal phase when the circulating concentrations of both estradiol and progesterone are high. The study suggests that AII may have a stimulatory role in the regulation of LH secretion, but this role is closely related to the gonadal steroid plasma levels
Effect of bromocriptine on the control of plasma aldosterone diurnal variation in normal supine man
No full textIn order to investigate the role of prolactin in the control of the circadian rhythm of plasma aldosterone (PA), plasma renin activity (PRA), cortisol (PC), aldosterone and prolactin (PRL) levels were determined in samples at 4-hour intervals from 5 normal supine men over a period of 24 h under basal conditions and subsequently over a period of 24 h during suppression of prolactin release by bromocriptine (CB-154). After suppression of prolactin, statistically signific1nt circadian rhythms in PC and PA have been detected with a moderate decrease of PA concentration, while the PC level remained unalterated. PRA rhythmicity persisted with a significant shift of acrophase and remarkable reduction of plasma levels. Moreover, during CB administration a significant correlation was obtained between PA and PC, while no correlation was detected between PA and PRA. These data are consistent with the following concepts: (a) the prolactin does not play a significant role in the regulation of circadian rhythm and concentration of plasma aldosterone in normal supine men, and (b) bromocriptine induces a remarkable reduction of PRA and a variable decrease in plasma aldosterone, but it does not influence the secretion of cortisol in normal subjects
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