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Pamela J. Roberts, Senior Recital, April 6, 1978
No full textConcert program for Pamela J. Roberts, Senior Recital, April 6,
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Pamela J. Bretz Interview, 1984
Full text linkPamela J. Bretz first joined the UMM Saddle Club during the 1977-78 school year when she was a senior at Morris High School. She later joined again during the 1980-81 school year when she attended UMN Morris for 1 year.
In this interview, Pamela discusses the changes she observed during that four year span, her personal reasons for joining the Saddle Club, and the satisfaction she received from the club. Other topics discussed were the disagreements encountered between the Saddle Club and Plant Services, the activities of the club, and some minor problems that occurred in the organization.https://digitalcommons.morris.umn.edu/stories/1047/thumbnail.jp
Data from manuscript “Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection”
No full textData file contains the animal information and quantitative image analysis results from our study of the early SIV-specific CD8 T cell responses during SIV infection.CD8+ T cells play an important role in controlling of HIV and SIV infections. However, these cells are largely excluded from B cell follicles where HIV and SIV producing cells concentrate during chronic infection. It is not known, however, if antigen-specific CD8+ T cells are excluded gradually as pathogenesis progresses from early to chronic phase, or this phenomenon occurs from the beginning infection. In this study we determined that SIV-specific CD8+ T cells were largely excluded from follicles during early infection, we also found that within follicles, they were entirely absent in 60% of the germinal centers (GCs) examined. Furthermore, levels of SIV-specific CD8+ T cells in follicular but not extrafollicular areas significantly correlated inversely with levels of viral RNA+ cells. In addition, subsets of follicular SIV-specific CD8+ T cells were activated and proliferating and expressed the cytolytic protein perforin. These studies suggest that a paucity of SIV-specific CD8+ T cells in follicles and complete absence within GCs during early infection may set the stage for the establishment of persistent chronic infection. This record shares the data collected by this study.This work was supported by a Public Health Service grant from the National Institutes of Health (grant R01AI096966), by Wisconsin National Primate Research Center grant P51OD011106/P51RR000167, by the Wisconsin National Primate Research Center Pathology and Scientific Protocol Implementation Units, NIH Tetramer Core Facility (contract HHSN272201300006C), by the NIH Nonhuman Primate Reagent Resource (grant R24 RR016001), and by the National Institute of Allergy and Infectious Diseases (contract HHSN 2722000900037C).Skinner, Pamela J.. (2018). Data from manuscript “Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection”. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/nss2-h623
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