1,720,968 research outputs found
Appunti di Chimica Analitica con esercitazioni numeriche per il corso di laurea in Farmacia
No full textQuesto libro deriva dall’elaborazione delle lezioni dell’insegnamento, svolto dall’autore, di Chimica analitica con esercitazioni numeriche e di laboratorio. Nella prima parte sono descritte nozioni di base per la Chimica analitica, tra cui le espressioni della concentrazione di soluzioni e la valutazione statistica di dati. Segue la trattazione degli equilibri chimici e delle applicazioni nell’analisi quantitativa classica. Un gran numero di esercizi svolti arricchisce la parte teorica. Gli esempi e i riferimenti al settore dei medicinali rendono il testo adatto in particolare agli studenti dei corsi di laurea in discipline farmaceutiche
Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives
No full textQuinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties
No full textThe quinoline motif fused with other heterocyclic systems plays an important role in the field of anticancer drug development.
An extensive series of tetracyclic quinolino[3,4-b]quinoxalines N-5 or C-6 substituted with basic side chain and
a limited number of tricyclic pyridazino[4,3-c]quinolines N-6 substituted were designed, synthesized and evaluated for
topoisomerase IIα (Topo IIα) inhibitory activity, ability to bind and stabilize G-quadruplex structures and cytotoxic properties
against two human cancer cell lines (HeLa and MCF-7). Almost all of the tested agents showed a high activity as
Topo IIα inhibitors and G-quadruplex stabilizers. Among all the derivatives studied, the quinolino[3,4-b]quinoxalines 11
and 23, N-5 and C-6 substituted respectively, stand out as the most promising compounds. Derivative 11 resulted a selective
binder to selected G-quadruplex sequences, while derivative 23 displayed the most interesting Topo IIα inhibitory
activity (IC50 = 5.14 μM); both showed high cytotoxic activity (IC50 HeLa = 2.04 μM and 2.32 μM, respectively)
Synthesis and structure-affinity relationships at the central benzodiazepine receptor of pyridazino4,3-bindoles and indeno1,2-cpyridazines
No full text
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs)
No full textThis report describes the process of developing a new type of multiple-choice question (MCQ), called sequential multiple-choice questions (SMCQs), in order to reduce the probability of answering correctly by chance and contrast the students' tendency to copy. In SMCQs the five possible answers to a question are connected to one another on an approximation scale towards the most probable answer
Synthesis and antibacterial activity of 2-aryl-2,5-dihydro-3(3H)-oxo-pyridazino4,3-bindole-4-carboxylic acids
No full textScreening of potential antiproliferative agents: analysis of the interaction of quinoxaline and cinnoline derivatives with DNA
No full textSynthesis.and biological evaluation of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines as new ligands of central and peripheral benzodiazepine receptors
No full text- …
