4,173 research outputs found
sj-pdf-1-vmj-10.1177_1358863X231215330 – Supplemental material for Despite celiprolol therapy, patients with vascular Ehlers–Danlos syndrome remain at risk of vascular events: A 12-year experience in an Italian referral center
No full textSupplemental material, sj-pdf-1-vmj-10.1177_1358863X231215330 for Despite celiprolol therapy, patients with vascular Ehlers–Danlos syndrome remain at risk of vascular events: A 12-year experience in an Italian referral center by Giacomo Buso, Anna Paini, Claudia Agabiti-Rosei, Carolina De Ciuceis, Fabio Bertacchini, Deborah Stassaldi, Massimo Salvetti, Marco Ritelli, Marina Venturini, Marina Colombi and Maria Lorenza Muiesan in Vascular Medicine</p
Solid-pseudopapillary, Acinar, and Other Cystic Neoplasms
No full textUncommon tumors of the pancreas are of increasing interest for clinicians: cross imaging techniques development makes it possible to detect small lesions in the pancreatic gland of asymptomatic patients, and in the last decades a more detailed and specific pathological classification definitivelyopened an unexpected world of more or less rare pancreatic tumors. As a matter of fact, nowadays most surgical procedures deal with these so called uncommon pancreatic tumors such as cystic, endocrine and others unfrequent histotypes, and many patientsexperiencing an accidental discovery of this type of tumor need therefore a specialistic evaluation. The concept behind this volume is the need to give the correct clinical relevance to these “uncommon” tumors, that are ranked at the first place among pancreatic tumors, and that are definitively curable with a multimodal approach. Aim of the book is therefore to get clinicians closer to these pathologies, describing their complexity and the current state of the art in diagnostic, therapeutic and pathological classification strategy, thus providing them with the tools for a modern and updated clinical management of these patients
The Dikkowita Marina Project
No full textThe large fishery harbour of Dikkowita faces some problems with respect to revenues and conflicts between the users. To create a higher revenue and to avoid these conflicts, a marina will be implemented. This report discusses the different aspects implementing a marina in the harbour of Dikkowita.Civil Engineering and Geoscience
Marina Martín Garcia
No full textIsla Martín Garcia is founded on a rock outcrop in the Río de la Plata which is a natural protected area between Argentina and Uruguay. Due to the extension of the runway at the local airport, wetlands between Isla Timoteo Domínguez and Isla Martín Garcia developed during the last decades. The bay, where the old port was located, was loaded with sediment. After the waters between the two islands sedimented, Isla Hércules is formed and a channel is created. For the location of the marina, three possible options are selected: at the pier, south of Isla Hércules and in the sedimented bay north of Isla Martín Garcia. By using a multi criteria analysis, a marina at the pier is chosen as the best option because of its small dredging area and minor environmental impact. In consultation with the consultative authorities, a marina at the bay is chosen as the elaborated alternative. The recovery of the old situation in which the marina is located in the bay is the main reason for this choice.Implementation of the marina at Isla Martín Garcia involves cooperation between two parties: the government and a second investor. The government is responsible for the island, and a certain amount of liquidity is required to boost tourism on the island. A second party, like a private investor, is introduced for the maintenance and exploration of the project. This cooperation needs to invest 22.9 million dollars; this includes the 16.4 million dollars for the government and 6.5 million dollars for the second party. Without involving an external investor the internal rate of return (IRR) is 1.77% which is very low. When involving a private investor the IRR increases, the external investor receives an IRR of 7.71 % over the entire lifetime of the marina.Hydraulic EngineeringCivil Engineering and Geoscience
Extent of surgery and implications of transection margin status after resection of IPMNs.
No full textAppropriate surgical strategies for management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a matter of debate. Preoperative and intraoperative evaluation of malignant potential of IPMN and of patient's comorbidities is of paramount importance to balance potential complications of surgery with tumors' risk of being or becoming malignant; the decision about the extent of pancreatic resection and the eventual total pancreatectomy needs to be determined on individual basis. The analysis of frozen-section margin of pancreas during operation is mandatory. The goal should be the complete resection of IPMN reaching negative margin, although there is still no agreed definition of "negative margin." Of note, the presence of deepithelization is often wrongly interpreted as absence of neoplasia. Management of resection margin status and stratification of surveillance of the remnant pancreas, based on characteristics of primary tumour, are of crucial importance in the management of IPMNs in order to decrease the risk of tumor recurrence after resection. Although risk of local and distant recurrence for invasive IPMNs is increased even in case of total pancreatectomy, also local recurrence after complete resection of noninvasive IPMNs is not negligible. Therefore, a long-term/life-time follow-up monitoring is of paramount importance to detect eventual recurrences
High-pressure and temperature extraction of phenolic compounds from corn silage
No full textCorn silage refers to stalks, leaves and cobs of maize plants that remain in fields after the corn harvest. Commonly it is used as a cattle feed, but recently it has been more often used together with cattle manure in biofuel production in anaerobic co-digestion. In this work high-pressure and temperature extraction of phenolic compounds from corn silage was performed. Process parameters (temperature, T = 90 - 180 °C; extraction time, t = 40 - 120 min; liquid - solid ratio, 10 - 20 mL/g; and solvent concentration (10 - 90 % aqueous ethanol, v/v) were studied. Box-Bhenken design was used in order to obtain the maximal extractability of phenolic compounds (namely total phenolic compounds- TPC and total extractible proanthocyanidins - TPA) and the maximal antiradical power (ARP) of obtained extracts. Experimental results of TPC, TPA, and ARP of corn silage extracts were in the range from 10.01 - 72.43 mgGallicAcid Equivalent/gdrybiomass, 0.27 - 3.21 mg/gdrybiomass and 1.25 - 16.76 mgDPPH/mLextract, respectively. Statistical results confirmed that temperature was the most significant factor affecting the observed responses (p < 0.05). Optimal extraction conditions for TPA and ARP were achieved at 180 °C, 120 min using 65 % ethanol and L/S ratio 10 while optimal conditions for TPC were achieved at 180 °C, 120 min using 10 % ethanol and L/S ratio 20. The results of this study evidenced that extracts from corn silage can be a good source of antioxidant compounds which can be used for production of food, cosmetic and pharmaceutical products
Developing a framework for an ecosystem-based approach to sustainable marina development: Including a framework application case study for a marina on the island of Mauritius, Indian Ocean
No full textThis thesis report considers the topic of sustainable marina development. This term can be understood to be a combination of two terms; “sustainable development” and “marina”. Sustainable development in this research study has been considered in relation to the coastal zone and basically entails an approach to ensure a balance between the environment and economic development. A marina, being a coastal (economic) development, interacts with the environmental conditions of the coastal zone and as such, affects the balance for sustainable development. Sustainable marina development is subsequently defined as the development of a marina in such a way and capacity, that the marina integrates its natural, social and economic environment. Additionally, a marina cannot be deemed sustainable by itself, as important principles for sustainable development like the cumulative impacts, multiple (long-term) objectives and sustainability need to be considered on the level of the larger coastal zone, or ecosystem. Currently, marina design is considered to lack an integrated development approach, and is inadequately represented in current marina development guidelines. Especially the initial stages of marina development, involving important development considerations like location selection and alternatives evaluation, lack the assessment of a marina’s integration in its natural, social and economic environment; a key element of sustainable development.Civil Engineering and GeosciencesHydraulic Engineerin
Differences between main-duct and branch-duct intraductal papillary mucinous neoplasms of the pancreas
No full textIn the last decade, intraductal papillary mucinous neoplasms (IPMNs) have become commonly diagnosed. From a morphological standpoint, they are classified in main-duct IPMNs (MD-IPMNs) and branch-duct IPMNs (BD-IPMNs), depending on the type of involvement of the pancreatic ductal system by the neoplasm. Despite the fact that our understanding of their natural history is still incomplete, recent data indicate that MD-IPMNs and BD-IPMNs show significant differences in terms of biological behaviour with MD-IPMNs at higher risk of malignant degeneration. In the present paper, clinical and epidemiological characteristics, rates of malignancy and the natural history of MD-IPMNs and BD-IPMNs are analyzed. The profile of IPMNs involving both the main pancreatic duct and its side branches (combined-IPMNs) are also discussed. Finally, general recommendations for management based on these differences are given
Feasibility study for a marina at Hook of Holland - Zeejachthaven Hoek van Holland: Haalbaarheidsstudie
No full textThe distance between marinas along the Dutch coast is large. By building marinas on strategic locations along the coast, sailing times can be reduced significantly. However, building marinas bordering the North Sea is expensive due to the lack of sheltering from waves. Hook of Holland is such a strategic location, located at a distance of 30 kilometers of Stellendam and 20 kilometers away from Scheveningen. The realization of a marina at Hook of Holland will lead to season lengthening, differentiation of the beach function and creates a boost for the local economy. In addition, it will be a stepping stone for creation of a network of marinas along the Dutch coast which will enable day trips from marina to marina, boosting the economy further. Waves in the marina basin will lead to damage to the yachts if the significant wave height Hs is higher than Hs =0.6 m. The design storm for the marina has a return period of 200 years and will lead to waves with a significant wave height up to Hs = 4.3 m at the project area. Also it will lead to a water level rise up to 4.2 m above NAP. To reduce the waves in the basin, a large breakwater is needed which is expensive. An entrance of the marina along the Nieuwe Waterweg is cheaper but politically unachievable. A previous study for a marina with the entrance along the Nieuwe Waterweg did not make it to realization due to this factor. A marina is mostly financed with real estate development and funding of the government. Real estate development at the project area is difficult to realize due to the nearby Natura 2000 area ‘Solleveld & Kapittel duinen’ and its associated strict nature legislation . Land reclamation is a possibility to make real estate development possible. However at the moment this is not attractive due to the prices for land reclamation are higher than inland development of these functions. Also the real estate market is in a downward state due to the economic crisis. A marina at Hook of Holland needs to be on a small scale and well integrated in the surroundings without a large land reclamation project, such a marina will cost around 50 million euro. A marina at Hook of Holland is technically feasible and has a positive effect on the required coastal maintenance. However the direct revenues are much lower than the construction costs. The indirect revenues are significant, however without a public investment there will be no marina realized at Hook of Holland.Hydraulic EngineeringCivil Engineering and Geoscience
Culture Takeaway
No full textThis keynote is mainly based on Wallace's research for Volume X of La Cultura Italiana published by UTET in 2010. The volume is in Italian and, by translating it, it can now be shared with colleagues, students and friends. The relationship that each citizen has with his/her own country and culture is mediated by personal experiences and matured during a lifetime. It is a delicate task to identify what motivates the consciousness of “insiders” of a culture whilst, at the same time, stimulating the interest of outsiders. To be able to observe the prodigious artistic production of one’s own country from the point of view of another culture and another genetic material offers fresh cues. Curiosity, prodded by geographical and physical distance, helps to identify in a schematic way those characteristics that define a country’s visual culture in a decisively distinctive way
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