2,384 research outputs found
La ricostruzione post-terremoto di Gibellina: ri-creazione dell’eredità culturale e attivazione di nuovi processi progettuali.
No full textLa storia di Gibellina è la storia straordinaria di una città ricostruita nella valle del Belice in Sicilia, dopo un terribile terremoto che nel 1968 la distrusse completamente. Ma al processo di ricostruzione, attuato dalla burocrazia dello stato, si è sovrapposto il progetto utopico del sindaco Ludovico Corrao: far rinascere, dopo una città che potesse accogliere arte e cultura, abitata da una comunità aperta e consapevole. Si avvia una stagione straordinaria di elaborazioni e produzioni culturali che costellano la città e il paesaggio, mentre Gibellina diventa centro internazionale di artisti e intellettuali.
Oggi, Gibellina è un luogo ricchissimo di opere d’arte e di architetture , ma è anche un luogo che sembra avviato a diventare un “sito archeologico” di una storia recentissima.
Si propone oggi di ricucire i pezzi di un enorme mosaico, fatto di artefatti e memorie, usando le nuove tecnologie, non per semplificare ma per dispiegare la complessità del patrimonio culturale di Gibellina. Attraverso la proposta di un archivio digitale e multimediale ci si propone di ricostruire le relazioni tra ciò che di quel patrimonio è visibile e ciò che nascosto o lontano o dimenticato
Design per i beni e le produzioni culturali nello scenario della crisi
No full textIl design ha da tempo elaborato e consolidato teorie e pratiche intorno alle tematiche dei BB.CC.; questa disciplina soprattutto ha evidenziato ed esplorato la grande potenzialità dei Beni Culturali come risorsa particolarmente diffusa nel territorio nazionale e sempre più centrale nello sviluppo territoriale; inoltre il patrimonio culturale è da ritenere una risorsa sostenibile e rinnovabile, in quanto attuatrice di processi di consapevolezza e accrescimento della conoscenza, fruibili, ma non soggetti al mero consumo.
Oggi, in tempo di crisi globale, accanto ai temi della valorizzazione e comunicazione, il design deve sviluppare una riflessione anche attorno alla produzione di nuovi valori che i BBCC possono attivare e per offrire alla società forme di resistenza e risposte efficaci agli effetti della crisi.For many years design has been elaborating and establishing theories and practices around cultural heritage issues. Above all this discipline highlighted and explored the huge potential of cultural heritage as a resource which is particularly diffused over the national territory and is becoming more and more central in territory development. Moreover, cultural heritage must be considered as a sustainable and renewable good, as it enables awareness and processes of knowledge growth, which are usable, yet not merely consumable.
Nowadays, in an era of global crisis, besides the subjects of valorisation and communication, design must reflect upon the new values that cultural heritage can activate, in order to offer to society modes of opposing and of effectively resolving the effects of the crisis
Frog intestinal sac as an in vitro method for the assessment of intestinal permeability in humans: Application to carrier transported drugs
No full textThe aim of this study was to investigate the presence of pharmaceutically relevant drug transporters in frog intestine which has been proposed as model for intestinal permeability screening assays of passively absorbed drugs in humans [Trapani, G., Franco, M., Trapani, A., Lopedota, A., Latrofa, A., Gallucci, E., Micelli, S., Liso, G., 2004. Frog intestinal sac: a new in vitro method for the assessment of intestinal permeability. J. Pharm. Sci. 93, 2909-2919]. The expression of transporters in frog intestine was supported by the following observations: (i) the involvement of purine nucleobase transport system was deduced by inhibition of acyclovir transport in the presence of adenine; (ii) baclofen or L-dopa transport was inhibited by the digitalis steroid ouabain and it may be related to the Na+ electrochemical potential difference, presumably involving amino acid transporters; (iii) the presence of proton-dependent peptide transporters was argued evaluating the effect of the pH change (from pH 5.9 to pH 7.4) on the transport of glutathione; (iv) the possible expression in the frog intestine of an efflux system distinct from P-glycoprotein (Pgp) in the benzylpenicillin transport was deduced using a glucose enriched frog Ringer with or without the known Pgp inhibitor verapamil; (v) the contribution of Pgp-mediated efflux system in determining the frog intestinal absorption of drugs was supported by the specific inhibition of cimetidine or nadolol transport in the presence of verapamil. These results indicate that pharmaceutically relevant drug transporters should be also expressed in frog intestine. In this work, an attempt was also made to compare the measured P-app values in the frog intestinal model for the aforementioned series of actively/effluxed transported drugs in humans to the corresponding literature values for the fraction absorbed. The P-app values used in these comparisons were obtained at high concentrations of drugs at which probably saturation of the carrier occurs. Interestingly, it was found that drugs that are completely absorbed had P-app values >3 x 10(-6) cm/s, while drugs absorbed <90% had P-app values lower than 1 x 10(-6) cm/s. In these cases, indeed, a borderline region characterized by the apparent permeability coefficient P-app value between 1 x 10(-6) and 3 x 10(-6) cm/s should be considered for which the prediction of the absorbed fraction after oral administration in humans become more uncertain by the frog intestinal sac system. (C) 2007 Elsevier B.V. All rights reserved
Gestione e sviluppo locale
No full textNel saggio curato da Ferdinando Trapani affronta aspetti che legano il problema della gestione turistica delle risorse locali dal punto di vista della programmazione che della pianificazione dello sviluppo territoriale. Il contributo di Ferdinando Trapani affronta una riflessione sulla problematica della gestione nel rapporto tra domanda e offerta turistica
Operator (Quasi-)Similarity, Quasi-Hermitian Operators and All that
No full textMotivated by the recent developments of pseudo-Hermitian quantum mechanics,
we analyze the structure generated by unbounded metric operators in a Hilbert
space. To that effect, we consider the notions of similarity and quasi-similarity between
operators and explore to what extent they preserve spectral properties. Then
we study quasi-Hermitian operators, bounded or not, that is, operators that are quasisimilar
to their adjoint and we discuss their application in pseudo-Hermitian quantum
mechanics. Finally, we extend the analysis to operators in a partial inner product
space (PIP-space), in particular the scale of Hilbert spaces generated by a single unbounded
metric operator.Motivated by the recent developments of pseudo-Hermitian quantum mechanics, we analyze the structure generated by unbounded metric operators in a Hilbert space. To that effect, we consider the notions of similarity and quasi-similarity between operators and explore to what extent they preserve spectral properties. Then we study quasi-Hermitian operators, bounded or not, that is, operators that are quasisimilar to their adjoint and we discuss their application in pseudo-Hermitian quantum mechanics. Finally, we extend the analysis to operators in a partial inner product space (pip-space), in particular the scale of Hilbert space s generated by a single unbounded metric operator
Integrating Cultural Content and Information Technologies in Cross-Media Platforms
No full textCultural products are consumed by a minority and little marketing research is done to meet
offers and demands. A larger base of potential consumers is an important requirement for
fund raising to allow to continue the production of services and cultural products. Widening
the audience implies also to emotionally engage people with different cultural background
and cultural expectations. Information technology has the potential to affect the cultural
sector introducing new model of fruition, breaking the barriers of time and space constraints
and integrating different platforms as delivery channels. We discuss some project proposals
Some classes of operators on partial inner product space
No full textMany families of function spaces, such as spaces, Besov spaces, amalgam spaces or modulation spaces, exhibit the common feature of being indexed by one parameter (or more) which measures the behavior (regularity, decay properties) of particular functions. All these families of spaces are, or contain, scales or lattices of Banach spaces and constitute special cases of the so-called \emph{partial inner product spaces (\pip s)} that play a central role in analysis, in mathematical physics and in signal processing (e.g. wavelet or
Gabor analysis).
The basic idea for this structure is that such families should be taken as a whole
and operators, bases, frames on them should be defined globally, for the whole family, instead of individual spaces.
In this talk, we shall give an overview of \pip s and operators on them, illustrating the results by families of spaces
of interest in mathematical physics and signal analysis. In particular, an operator on a \pip\ is a {\em coherent} collection of linear maps, each one of them acting on one space of the family: they are often regular objects when considered on the global structure of a \pip\ but possibly singular when considered in an individual space. Various classes of operators will be considered and the link between (partial) *-algebras of operators on a \pip\ and (partial) *-algebras of unbounded operators acting in Hilbert spaces will be briefly discussed
Fourier coefficients of invariant random fields on homogeneous spaces of compact Lie groups
No full textLet T be a random field invariant under the action of a compact group G. We investigate properties of the Fourier coefficients as orthogonality and Gaussianity. In particular we give conditions ensuring that independence of the random Fourier coefficients implies Gaussianity. As a consequence, in general, it is not possible to simulate a non-Gaussian invariant random field through its Fourier expansion using independent coefficients. end{abstract
Burst mode versus single-pulse machining for Bessel beam micro-drilling of thin glass: study and comparison
No full textCan Adeno-Associated Viral Vectors Deliver Effectively Large Genes?
No full textGene therapy with adeno-associated viral (AAV) vectors has reached the clinical stage for many inherited and acquired diseases. However, due to a cargo capacity limited to <5 kb, AAV-mediated treatment of diseases that require transfer of larger genes still appears elusive. This is a major drawback of a platform that has otherwise been repeatedly found to be safe and effective. Thus, great efforts have been directed toward the identification of strategies to overcome this limitation. Among the most studied approaches is the use of dual vectors, in which a transgene is split across two separate AAV vectors. Mechanisms acting at either the DNA, pre-mRNA, or protein levels have been explored to restore full-length transgene expression in infected cells. Here, we will review them as well as additional strategies developed to deliver large genes with AAV. We discuss the pros and cons of these strategies and the aspects that still need to be addressed
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