1,359 research outputs found

    J. Capart et alii, Toutankhamon et P. Montet, Tanis

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    De Morant Henry. J. Capart et alii, Toutankhamon et P. Montet, Tanis. In: Annales. Économies, Sociétés, Civilisations. 2ᵉ année, N. 2, 1947. pp. 237-238

    Tanis: a link between type 2 diabetes and inflammation?

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    Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct proportion with plasma triglyceride concentrations (P = 0.007). Hepatic Tanis gene expression was markedly increased (3.1-fold) after a 24-h fast in diabetic but not in nondiabetic P. obesus. In addition, glucose inhibited Tanis gene expression in cultured hepatocytes (P = 0.006) as well as in several other cell types (P = 0.001–0.011). Thus, Tanis seems to be regulated by glucose and is dysregulated in the diabetic state. Yeast-2 hybrid screening identified serum amyloid A (SAA), an acute-phase inflammatory response protein, as an interacting protein of Tanis, and this was confirmed by Biacore experiments. SAA and other acute-phase proteins have been the focus of recent attention as risk factors for cardiovascular disease, and we contend that Tanis and its interaction with SAA may provide a mechanistic link among type 2 diabetes, inflammation, and cardiovascular disease.<br

    Fouilles de Tanis en 1938

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    Montet Pierre. Fouilles de Tanis en 1938. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 82ᵉ année, N. 3, 1938. p. 285

    Compte rendu des fouilles à Tanis (Égypte)

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    Montet Pierre. Compte rendu des fouilles à Tanis (Égypte). In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 81ᵉ année, N. 2, 1937. p. 142

    Elevation in tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells

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    Increased hepatic glucose output and decreased glucose utilization are implicated in the development of type 2 diabetes. We previously reported that the expression of a novel gene, Tanis, was upregulated in the liver during fasting in the obese/diabetic animal model Psammomys obesus. Here, we have further studied the protein and its function. Cell fractionation indicated that Tanis was localized in the plasma membrane and microsomes but not in the nucleus, mitochondria, or soluble protein fraction. Consistent with previous gene expression data, hepatic Tanis protein levels increased more significantly in diabetic P. obesus than in nondiabetic controls after fasting. We used a recombinant adenovirus to increase Tanis expression in hepatoma H4IIE cells and investigated its role in metabolism. Tanis overexpression reduced glucose uptake, basal and insulin-stimulated glycogen synthesis, and glycogen content and attenuated the suppression of PEPCK gene expression by insulin, but it did not affect insulin-stimulated insulin receptor phosphorylation or triglyceride synthesis. These results suggest that Tanis may be involved in the regulation of glucose metabolism, and increased expression of Tanis could contribute to insulin resistance in the liver.<br

    On the alleged phonetic value /p/ of the frog hieroglyph in Ptolemaic

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    The present article deals with two passages (Esna n° 379, 9 and Edfu III, 190, 2) which feature the frog hieroglyph with a supposed phonetic value /p/. While an alternative reading /H/ is suggested for the first text, the other requires returning to Nefertari’s tomb for disclosure of the frog’s meaning

    Comparison between TANIS and UICC 1997 stage grouping in parotid gland carcinoma

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    To compare the correlation of T and N Integer Score (TANIS) and International Union Against Cancer (UICC) '97 stage grouping with survival rate in parotid gland carcinoma, a series of 134 patients affected by primary carcinoma of the parotid gland was considered in this retrospective study. Data set was classified according to 1997 UICC T-category and then grouped as recommended by the two systems. Data were analyzed by means of survival analyses (Kaplan-Meier and Cox algorithms). Results showed a crude survival rate of 64.9%. Univariate analysis by means of log-rank test yielded significant P values both for TANIS and UICC '97 systems (both P &lt; 0.0001). Multivariate analysis (Cox regression adjusted for age and gender) showed a significant correlation between the two staging systems with the mortality rate. Odds ratios were 2.64 (95% CI 1.84-3.80) and 1.79 (95% CI 1.46-2.20) for UICC '97 and TANIS, respectively. In testing the superiority, UICC '97 resulted in a higher prognostic value and TANIS did not add any statistical contribution in determining survival. In conclusion, the new UICC stage grouping better defines the prognosis for cancer of the parotid gland

    P. Montet — Les nouvelles fouilles de Tanis (1929-1932) (Publications de la Faculté des Lettres de Strasbourg, 2me série, vol. 10). Paris, Les Belles Lettres, 1933

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    Mouterde René. P. Montet — Les nouvelles fouilles de Tanis (1929-1932) (Publications de la Faculté des Lettres de Strasbourg, 2me série, vol. 10). Paris, Les Belles Lettres, 1933. In: Mélanges de l'Université Saint-Joseph, tome 17, 1933. pp. 201-203

    P. Montet, Les nouvelles fouilles de Tanis, 1929-1932 (Publications de la Faculté des lettres de Strasbourg, 2e série, vol. X), 1933

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    Radet Georges. P. Montet, Les nouvelles fouilles de Tanis, 1929-1932 (Publications de la Faculté des lettres de Strasbourg, 2e série, vol. X), 1933. In: Revue des Études Anciennes. Tome 36, 1934, n°2. pp. 257-259

    Lettre rectificatrice au sujet des découverte dans la nécropole de Tanis (Égypte)

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    Montet Pierre. Lettre rectificatrice au sujet des découverte dans la nécropole de Tanis (Égypte). In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 83ᵉ année, N. 2, 1939. p. 188
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