357 research outputs found
Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease
No full textTyrosine hydroxylase (TH, the rate limiting-enzyme in catecholamine synthesis) is regulated acutely via phosphorylation of 3 serine residues--Ser19, 31 and 40, and chronically via changes in TH protein levels. In this study, we aimed to investigate how TH is regulated in the brain, gut and adrenal gland as well as changes in mature brain-derived neurotrophic factor (mBDNF) and proBDNF levels in a low-dose (2 mg/kg, 5 days/week for 4 weeks) rotenone model of Parkinson's disease (PD). Rearing behaviour decreased by week 3 in the rotenone group (p<0.01), with further decreases in rearing by week 4 (p<0.001); however, TH remained unchanged in the substantia nigra (SN) and striatum; TH levels were also unaltered in other catecholaminergic cell groups of the brainstem such as A1C1 neurons or locus coeruleus. In the olfactory bulb, TH protein decreased (2.5-fold, p<0.01) while Ser31 phosphorylation increased (1.4-fold, p<0.05) in the rotenone group. In contrast, TH protein was increased in the adrenal gland (2-fold, p<0.05) and colon (5-fold, p<0.05) of rotenone rats. mBDNF levels were not changed in the SN but were significantly reduced in plasma and significantly increased in the colon (2-fold, p<0.01) of rotenone-treated rats. This is the first study to assess TH and BDNF in the brain and periphery in the rotenone model before SN/striatum degeneration is evident. Together these results suggest that low-dose rotenone may have some potential to model the early stages of PD.Michaela E.Johnson, Yoon Lim, Manjula Senthilkumaran, Xin-Fu Zhou, Larisa Bobrovskay
Periorbital swelling in emergency room: Get your eyes in
No full textFacial swelling and eye pain are very common patient complaints in Emergency Departments. Clinical evidence and investigations play a crucial role in making the correct diagnosis which impacts the final disposition and management of the patient. We present a case of a patient who presented with facial swelling and headache
Robot navigation control based on monocular images: An image processing algorithm for obstacle avoidance decisions
No full textThis paper covers the use of monocular vision to control autonomous navigation for a robot in a dynamically changing environment. The solution focused on using colour segmentation against a selected floor plane to distinctly separate obstacles from traversable space, this is then supplemented with canny edge detection to separate similarly coloured boundaries to the floor plane. The resulting binary map (where white identifies an obstacle-free area and black identifies an obstacle) could then be processed by fuzzy logic or neural networks to control the robot’s next movements. Findings shows that the algorithm performed strongly on solid coloured carpets, wooden and concrete floors but had difficulty in separating colours in multi-coloured floor types such as patterned carpets
Reply to Jalink, M.B. Comment on “Senthilkumaran et al. Bilateral Simultaneous Optic Neuritis Following Envenomations by Indian Cobra and Common Krait. <i>Toxins</i> 2022, <i>14</i>, 805”
No full textWe thank the author for showing interest in our article [...
A quantitative analysis of the spices literature in India
No full text152-157Analyses the quantitative literature on spices for the period 1968 to 2002 with respect to Asia and India using HORT-CD
database. Identifies the distribution of spices literature by categories of spices, forms of publications, core journals, prime
authors and institutions. Reveals that India dominates research and development activities on spices in the Asian continent and
Indian Institute of Spices Research is a significant contributor whose scientists top the list of prolific authors
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