1,721,113 research outputs found
Combinatorial chemistry: basic principles and new trends
No full textA review with 23 refs. While many excellent reviews covered this subject , here the author briefly provides the reader with the basic principles which constitute the foundation of this new technol
Solid-Phase Synthesis and Combinatorial Technologies
No full textA unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies
The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines
Small molecules as pro-apoptotic anticancer agents
No full textThe quest for potent and selective targeted therapies in anticancer research is taking advantage of apoptosis-related mechanisms of action to identify a no. of novel clin. candidates. This review is chem. focused on small mols. and deals with five target families that influence caspase-dependent apoptosis: caspase-3, Bcl-2 and IAP protein family members, p53 and the proteasome. Each target class is briefly described at first in terms of its involvement and relevance in tumor initiation and progression. Drug candidates currently undergoing clin. trials are then presented for each target class, followed by a quick summary of target-modulating chemotypes that have appeared in patent literature since 2006. Finally, future trends likely to become significant in apoptosis-targeted cancer therapies are presented and discussed
New technologies in the third millennium. Applications in the discovery of new drugs and in catalysis
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Fragment-Based Drug Discovery--CHI's Fourth Annual Meeting. 6-7 April 2009, San Diego, CA, USA
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