147 research outputs found
Microstructure and mechanical properties of nickel coated multi walled carbon nanotube reinforced stainless steel 316L matrix composites by laser sintering process
No full textAnthocyanin modified triphenylamine based organic sensitizer for dye sensitized solar cells (DSSC) - A theoretical approach
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Bovine reproductive infectious disease in Ghana : prevalence and pathogenesis of early infection with an emphasis on trichomoniasis
No full textReproductive inefficiency is one of the most costly and production limiting problems facing the livestock development in Africa. Reproductive performance is influenced by a number of important factors, among which are infectious diseases, which result in lost production. Research in these diseases is critical in order to overcome these shortfalls.The objectives of the following studies were to provide a more in-depth epidemiological analysis of infectious reproductive diseases in Sub-Saharan Africa and further investigate the cytokine environment and molecular factors involved in the innate immune response of the bovine reproductive tract to infectious agents which can play such an important role in livestock production in Africa, in particular Tritrichomonas foetus. The prevalence of important infectious reproductive diseases in a single herd using serology was investigated. Significantly, high seroprevalence of infectious bovine rhinotraechitis and trichomoniasis was demonstrated. The presence of coxiellosis, neosporosis, bovine viral diarrhea virus, and bovine herpesvirus-4, was demonstrated but not serological evidence of brucellosis. Significant associations were found between the seroprevalence of the different viral pathogens but no such association was noted between the other pathogens. The long calving interval in this herd could be due to the presence of these pathogens. Among the diseases we identified, we further studied trichomoniasis (T. foetus) and the host immune response in a mouse model. Serum and reproductive tissues for Th1 and Th2 cytokines (specifically INF-\ue3, TNF-\ue1, IL-2, IL-4, and IL-5) via flow cytometry after 5 days of T. foetus infection were analyzed. Mice of varying ages which had different susceptibility to T. foetus infection were used to assess whether a Th1 or Th2 cytokine environment was significantly associated with successful infection. Both Th1 and Th2 cytokines (TNF-\ue1, IL-4 and IL-2) were shown to be significantly altered in infected animals. Lastly, by using PCR and IHC techniques, the presence of the novel dual oxidase molecules (DUOX 1 and 2) in the reproductive tract of cows and in bovine endometrial and trophoblast cell cultures was documented. However, there was no significant difference in DUOX 1(P=0.296) or DUOX2 (P=0.480) expression in T. foetus infected cells versus their respective controls. In conclusion, several important infectious diseases in Ghanaian cattle which may affect reproduction, not the least of which is trichomoniasis, were detected. Further, it was demonstrated that the early infection has both Th1 and Th2 cytokine involvement and that while present in the reproductive tract, there is no evidence that the DUOX molecules play a role in early resistance, but they may be important at other time points.Thesis (Ph. D.)--Michigan State University. Pathology, 2012Includes bibliographical reference
[Cu(N^N)(P^P)]+ complexes with 2,2':6',2''-terpyridine ligands as the N^N domain
No full textThe first examples of [Cu(N^N)(POP)]+ complexes (POP = bis(2-(diphenylphosphino)phenyl)ether) in which the N^N domain is a 2,2′:6′,2′′-terpyridine (tpy) ligand have been prepared and characterized; N^N = tpy, 5,5′′-dimethyl-2,2′:6′,2′′-terpyridine (1), 4′-(4-tolyl)-2,2′:6′,2′′-terpyridine (2), 4′-(4-npropoxyphenyl)-2,2′:6′,2′′-terpyridine (3) and 4′-(4-nbutoxyphenyl)-2,2′:6′,2′′-terpyridine (4). In solution, the tpy domain in each [Cu(N^N)(POP)][PF6] complex is C2-symmetric, consistent with either tridentate coordination or a low energy dynamic process involving bidentate ligands; for [Cu(2)(POP)][PF6] and [Cu(4)(POP)][PF6], the 1H NMR spectra showed negligible change between 295 and 210 K. The single crystal structures of [Cu(tpy)(POP)][PF6] and [Cu(4)(POP)][PF6] are presented. The asymmetric unit of [Cu(tpy)(POP)][PF6] contains two independent cations; in one the tpy ligand is tridentate and in the other, it is bidentate with the non-coordinated pyridine ring facing the Cu atom (Cu⋯N = 3.146(1) Å). In contrast, the solid-state structure of [Cu(4)(POP)][PF6] features a [Cu(4)(POP)]+ cation containing a bidentate tpy-domain with the non-coordinated pyridine ring oriented with the N-atom facing away from the Cu atom; this conformation may be associated with inter-cation N⋯HC non-classical hydrogen bonds. The photophysical properties of [Cu(N^N)(POP)][PF6] with N^N = tpy or 1–4 are described. In the solid state at room temperature, the compounds are poorly emissive. In solution, the emission behaviour is consistent with ligand dissociation. This is supported by 1H and 31P NMR spectroscopic data which show POP and [Cu(POP)2]+ in solutions of aged samples; mass spectrometric data are consistent with the formation of [Cu(N^N)2]2+ in these samples
Particulate matter formation and its control methodologies for diesel engine: A comprehensive review
No full textGraph-theoretic and computational analysis of QSAR molecular descriptors for single chain diamond silicates
No full textAbstract This study presents a comprehensive graph-theoretic and computational analysis of Quantitative Structure–Activity Relationship (QSAR) molecular descriptors for Single Chain Diamond Silicates (CSn), a crucial class of silicate structures defined by their unique connectivity of SiO₄ tetrahedra. Various molecular descriptors, including the Atom Bond Connectivity (ABC) Index, Atom Bond Sum Connectivity (ABS) Index, Augmented Zagreb Index (AZI), Sum Augmented Zagreb Index (SZI), Geometric Arithmetic Index (GAI), and Arithmetic Geometric Index (AGI), are examined to assess their structural, electronic, and thermodynamic properties. Through mathematical formulations and computational modelling, this study quantifies the complexity, stability, and connectivity patterns of CSn, enhancing the predictive capabilities of QSAR models. The findings underscore the significance of molecular descriptors in characterising silicate networks, with applications spanning materials science, catalysis, and geochemistry
Chronic Exposure to Low Levels of Oestradiol‐17β Affects Oestrous Cyclicity, Hypothalamic Norepinephrine and Serum Luteinising Hormone in Young Intact Rats
No full textHyposmia impending neurodegeneration in rapid eye movement sleep behavior disorder
No full textBackground- Approximately 50% to 80% of people with isolated rapid eye movement (REM) sleep behavior disorder (RBD) will likely be diagnosed with an overt synucleinopathy within their lifetimes. Objective- To determine if hyposmia in isolated REM sleep behavior disorder (IRBD) predicts short-term conversion. Methods- Olfaction was tested using the University of Pennsylvania Smell Identification Test (UPSIT-40) in 100 consecutive patients with polysomnography-confirmed IRBD and in 100 matched controls. Patients were followed up for two years. The study was approved by the institutional ethics committee, and participants provided written informed consent. Results- The study was a male preponderance comprising 76% in cases and 70% in controls, and they were comparable to females and were not significant.(p>0.05). UPSIT-40 score was lower (poorer smell identification) in patients than in controls (20.3 ± 6.4 vs. 28.4 ± 4.9), and it was statistically significant (p<0.05). 60% of patients had hyposmia and showed 14.2 ± 2.8 scores. No differences occurred in age (p = 0.11), gender (p = 0.38) and follow-up duration (p = 0.65) between hyposmics and normosmics. 
STUDY ON THE REPLACEMENT OF CEMENT AND FINE AGGREGATE WITH QUARRY DUST
No full text<p>Quarry dust is the crusher waste of granite quarries which is about 13-15 % of the total quarry products and accumulation of this waste generates environmental issues. For the past three decades, the scarcity of river sand has been taken seriously and research initiated to replace it with quarry dust either in the available form, or fines removed or processed sand. The presence of very fine particles found as 5-8% demands for increased water cement ratio for better workability which could reduce the strength of the concrete. Therefore it is emphasized, to replace cement partially with these fines of quarry dust to produce cost effective concrete. This studyis planned to make concrete totally replacing river sand with the quarry dust considering the fine fraction of quarry dust present for partial replacement of cement.Concrete of M30 grade has been designed by usingfines removed coarser quarry dust as fine aggregate. The cement is replaced with fines of quarry in 0, 2, 4, 6, 8 and 10% by weight. Seven different concrete mixes are prepared, tested and compared in terms of workability and strength with the conventional sand concrete of same grade. It is observed that the optimum replacement level of cement with fines of quarry dust is 6%.</p>
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